Evaluation of release retarding property of gum damar and gum copal in combination with hydroxypropyl methylcellulose.

Abstract:

:The formulations consisting of a hydrophilic and hydrophobic material were investigated for effect on drug-release pattern from the matrices. Gum damar and gum copal being water-insoluble were used to study the efficiency of combined matrices to sustain the release of drug. Hydroxypropyl methylcellulose K100M and diclofenac sodium were used as the hydrophilic material and model drug, respectively. The influence of concentration of hydroxypropyl methylcellulose on drug release pattern of hydrophobic material was determined. The optimum ratio of drug: polymer was found to be 1:1. The hydrophobic:hydrophilic polymer ratio of 75:25 was found to have a similar release pattern as that of marketed formulation. At this ratio, the initial burst-release that occurred in individual hydrophobic matrices was lowered to a great extent. The release of drug was found to follow Higuchi's equation as the concentration of hydrophobic material was increased. The formulations were compared with marketed formulation Voveran SR, and a correlation was drawn accordingly.

journal_name

Indian J Pharm Sci

authors

Fulbandhe VM,Jobanputra CR,Wadher KJ,Umekar MJ,Bhoyar GS

doi

10.4103/0250-474X.106059

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

189-94

issue

3

eissn

0250-474X

issn

1998-3743

pii

IJPS-74-189

journal_volume

74

pub_type

杂志文章
  • Hepatoprotective Activity of Heptoplus on Isoniazid and Rifampicin Induced Liver Damage in Rats.

    abstract::The present study is designed to evaluate the efficacy of heptoplus a polyherbal formulation as an oral supplementary agent for isoniazid and rifampicin induced hepatotoxicity in rats. 50 and 100 mg/kg of heptoplus supplement were fed orally to the rats along with isoniazid and rifampicin and compared to rats treated ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.169028

    authors: Sankar M,Rajkumar J,Sridhar D

    更新日期:2015-09-01 00:00:00

  • Effect of time of harvesting on yield and quality of melissa officinalis L. In doon valley, India.

    abstract::A field experiment on the effect of time of harvesting on yield and quality of Melissa officinalis L. was conducted under the agroclimatic conditions of Doon valley, Uttarakhand in order to assess the performance of four harvesting times (H1-120 days, H2-140 days, H3-160 days and H4-180 days after planting). The fresh...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Singh S,Haider SZ,Chauhan NK,Lohani H,Sah S,Yadav RK

    更新日期:2014-09-01 00:00:00

  • Self Medication Practices among Medical Students of a Private Institute.

    abstract::The study was undertaken to evaluate various aspects of self-medication in medical students. A prospective, cross-sectional, questionnaire-based study was carried out among 488 medical students selected by simple random sampling from January 2013 to June 2013. Data was collected and analyzed for counts and percentage....

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.156569

    authors: Kasulkar AA,Gupta M

    更新日期:2015-03-01 00:00:00

  • In vivo Antimalarial Activities of Russelia Equisetiformis in Plasmodium Berghei Infected Mice.

    abstract::The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.164787

    authors: Ojurongbe O,Ojo JA,Adefokun DI,Abiodun OO,Odewale G,Awe EO

    更新日期:2015-07-01 00:00:00

  • Effect of 2-Hydroxy-4-methoxy Benzoic Acid Isolated from Hemidesmus indicus on Erythrocyte Membrane Bound Enzymes and Antioxidant Status in Streptozotocin-induced Diabetic Rats.

    abstract::In the present study, the effect of 2-hydroxy-4-methoxy benzoic acid isolated from roots of Hemisdesmus indicus on the erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats was investigated. The streptozotocin-induced diabetic rats were treated with 2-hydroxy-4-methoxy benzo...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.108438

    authors: Gayathri M,Kannabiran K

    更新日期:2012-09-01 00:00:00

  • Antihyperglycemic Activity of Petroleum Ether Leaf Extract of Ficus krishnae L. on Alloxan-induced Diabetic Rats.

    abstract::The petroleum ether leaf extract of Ficus krishnae has been evaluated for the management of diabetes in alloxan induced diabetic rats. Phytochemical screening of the leaf extract for various chemical compounds has also been carried out. Leaf extract was administered continuously for 21 days orally at a dose of 200 mg/...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Sidhu MC,Sharma T

    更新日期:2014-07-01 00:00:00

  • Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.

    abstract::Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human h...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Viswanathan V,Phadatare AG,Mukne A

    更新日期:2014-05-01 00:00:00

  • Spectrophotometric estimation of olmesartan medoxomil and hydrochlorothiazide in tablet.

    abstract::A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan me...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.62245

    authors: Rote AR,Bari PD

    更新日期:2010-01-01 00:00:00

  • Development and Validation of Stability-indicating RP-HPLC Method for Estimation of Pamabrom in Tablets.

    abstract::The present study depicts the development of a validated RP-HPLC method for the determination of the pamabrom in presence of degradation products or other pharmaceutical excipients. Stress study was performed on pamabrom and it was found that it degrade sufficiently in acidic, alkali and oxidative condition but less d...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Shah U,Kavad M,Raval M

    更新日期:2014-05-01 00:00:00

  • Attenuation of Acute and Chronic Restraint Stress-induced Perturbations in Experimental Animals by Nelumbo nucifera Gaertn.

    abstract::Aqueous extract of leaves of Nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the ext...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.42982

    authors: Kulkarni MP,Juvekar AR

    更新日期:2008-05-01 00:00:00

  • Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations.

    abstract::The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.108417

    authors: Siddiqui MZ,Mazumder PM

    更新日期:2012-09-01 00:00:00

  • Neuroprotective Activity of Pongamia pinnata in Monosodium Glutamate-induced Neurotoxicity in Rats.

    abstract::This study was designed to evaluate the neuroprotective activity of ethanol extract of Pongamia pinnata stem bark in monosodium glutamate-induced neurotoxicity in rats. Neurotoxicity was induced by intraperitoneal injection of monosodium glutamate 2 g per kg body weight daily for 7 days. Ethanol extract of Pongamia pi...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Swamy AH,Patel NL,Gadad PC,Koti BC,Patel UM,Thippeswamy AH,Manjula DV

    更新日期:2013-11-01 00:00:00

  • Meltlets(®) of soy isoflavones: process optimization and the effect of extrusion spheronization process parameters on antioxidant activity.

    abstract::In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheroniza...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.119831

    authors: Deshmukh K,Amin P

    更新日期:2013-07-01 00:00:00

  • Cytofectin amine head group modification and degree of liposome pegylation: factors influencing gene transfer.

    abstract::The effectiveness of liposome-mediated gene transfer methods hinges, in part, on the nature of the interaction between the DNA cargo and the liposomes. Here we have examined the effect of quaternization of the cytofectin cationic head group on this interaction and the effect of concentration of the biocompatible, prot...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.95613

    authors: Daniels A,Noor-Mahomed N,Singh M,Ariatti M

    更新日期:2011-07-01 00:00:00

  • Antimicrobial Activity of Medicated Soaps Commonly Used By Dar es Salaam Residents in Tanzania.

    abstract::An in vitro evaluation of the anti-microbial activity of medicated soaps was conducted using ditch-plate and hand washing techniques. Strains of reference microbes namely Candida albicans (ATCC90028), Staphylococcus aureus (ATCC25923), Pseudomonas aureginosa (ATCC27853) and Escherichia coli (ATCC25922) were tested at ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.89765

    authors: Mwambete KD,Lyombe F

    更新日期:2011-01-01 00:00:00

  • Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice.

    abstract::In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.70487

    authors: Pathak S,Wanjari MM,Jain SK,Tripathi M

    更新日期:2010-05-01 00:00:00

  • Evaluation of Antiinflammatory Activity of Centratherum anthelminticum (L) Kuntze Seed.

    abstract::In the present study petroleum ether and alcoholic extracts of Centratherum anthelminticum (L) Kuntze seed (100 mg and 200 mg/kg p.o.) were evaluated for antiinflammatory activity in acute and subacute models of inflammation. It was found that both petroleum ether and alcoholic extracts showed significant reduction in...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.84577

    authors: Ashok P,Koti BC,Thippeswamy AH,Tikare VP,Dabadi P,Viswanathaswamy AH

    更新日期:2010-11-01 00:00:00

  • Hypoglycemic Effect of the Methanol flower Extract of Piper Claussenianum and the Major Constituent 2',6'-dihydroxy-4'-methoxychalcone in Streptozotocin Diabetic Rats.

    abstract::Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels of rats treated with methanol extract were reduced from 318.4±28.1 mg/dl before treatment to 174.2±38.3 mg/dl after 12 days of treatment (P<0.05). Phytochemical...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.156624

    authors: Marques AM,Pereira SL,Paiva RA,Cavalcante CV,Sudo SZ,Tinoco LW,Moreira DL,Guimaraes EF,Sudo RT,Kaplan MA,Sudo GZ

    更新日期:2015-03-01 00:00:00

  • A Novel Metabolite from Aspergillus ochraceus JGI 25 Showing Cytotoxicity to Hela Cells.

    abstract::This study aims at the isolation of filamentous fungi, extraction of metabolites, and evaluation of the cytotoxic properties on HeLa cells and normal human lymphocytes. We isolated fungi from the soil by serial dilution method. One of the isolates was chosen and identified as Aspergillus ochraceus Wilhelm (Trichocomac...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:

    authors: Nadumane VK,Venkat P,Pal A,Dharod H,Shukla M,Prashanthi K

    更新日期:2013-09-01 00:00:00

  • In vitro Antibacterial Activity of Aqueous and Ethanol Extracts of Aristolochia indica and Toddalia asiatica Against Multidrug-Resistant Bacteria.

    abstract::Bacteria have developed multidrug resistance against available antimicrobial agents. Infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. Synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffec...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.174991

    authors: Venkatadri B,Arunagirinathan N,Rameshkumar MR,Ramesh L,Dhanasezhian A,Agastian P

    更新日期:2015-11-01 00:00:00

  • Optimization of Physical and Nutritional Parameters for Hyaluronidase Production by Streptococcus mitis.

    abstract::The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. The effects of initial pH, incubation temperature and time, inoculum level and age of inoculum were studied. The maximu...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.45412

    authors: Sahoo S,Panda PK,Mishra SR,Nayak A,Dash SK,Ellaiah P

    更新日期:2008-09-01 00:00:00

  • Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles.

    abstract::In the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. The structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, UV, IR, ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.40331

    authors: Nagalakshmi G

    更新日期:2008-01-01 00:00:00

  • Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins.

    abstract::In this paper we report the synthesis of a new family of 4-alkyl isocoumarin derivatives having bromo carbonyl and amino carbonyl group at 3(rd) position of the heterocyclic ring. Synthesis, spectral analysis and bioactivity of new isocoumarin derivatives are discussed in this paper. Some of the synthesized compounds ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474x.91586

    authors: Yadav P,Purohit NV

    更新日期:2011-03-01 00:00:00

  • A Sensitive RP-HPLC Method for Simultaneous Estimation of Diethylcarbamazine and Levocetirizine in Tablet Formulation.

    abstract::A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.93517

    authors: Reddy JM,Jeyaprakash MR,Madhuri K,Meyyanathan SN,Elango K

    更新日期:2011-05-01 00:00:00

  • Wound healing potential of formulated extract from hibiscus sabdariffa calyx.

    abstract::Wound healing agents support the natural healing process, reduce trauma and likelihood of secondary infections and hasten wound closure. The wound healing activities of water in oil cream of the methanol extract of Hibiscus sabdariffa L. (Malvaceae) was evaluated in rats with superficial skin excision wounds. Antibact...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.113549

    authors: Builders PF,Kabele-Toge B,Builders M,Chindo BA,Anwunobi PA,Isimi YC

    更新日期:2013-01-01 00:00:00

  • Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin.

    abstract::Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.70477

    authors: Sapkal NP,Kilor VA,Shewale BD,Bhusari KP,Daud AS

    更新日期:2010-05-01 00:00:00

  • Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone.

    abstract::Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as ...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51944

    authors: Prajapati ST,Patel LD,Patel DM

    更新日期:2009-01-01 00:00:00

  • Antibacterial activity of essential oils from palmarosa, evening primrose, lavender and tuberose.

    abstract::Essential oils extracted from flower petals of palmarosa (Cymbopogon martini), evening primrose (Primula rosea), lavender (Lavandula angustifolia) and tuberose (Polianthus tuberosa) were tested for their antibacterial activities against gram-positive and gram-negative bacteria. Different concentrations of each essenti...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.54278

    authors: Lodhia MH,Bhatt KR,Thaker VS

    更新日期:2009-03-01 00:00:00

  • Spectrophotometric estimation of ropinirole hydrochloride in tablets.

    abstract::A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for estimation of ropinirole hydrochloride in bulk and tablet dosage forms. Ropinirole hydrochloride shows maximum absorbance at 250 nm with molar absorptivity of 8.703x10(3) l/mol.cm. Beer's law was obeyed in the concentrati...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.51962

    authors: Shete Y,Pimpodkar N,Nalawade RS,Pore YV,Kuchekar BS

    更新日期:2009-01-01 00:00:00

  • Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method.

    abstract::Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superd...

    journal_title:Indian journal of pharmaceutical sciences

    pub_type: 杂志文章

    doi:10.4103/0250-474X.98984

    authors: Shirsand SB,Suresh S,Kusumdevi V,Swamy PV

    更新日期:2011-09-01 00:00:00