Changing central nervous system control following intercostal nerve transfer.

Abstract:

OBJECT:The goal of this study was to find which central nervous system (CNS) pathways are involved in volitional control over reinnervated biceps or pectoral muscles. METHODS:Intercostal nerves (ICNs) were coapted to the musculocutaneous nerve (MCN) or the medial pectoral nerve (MPN) in 23 patients with root avulsions of the brachial plexus to restore biceps or pectoral muscle function. The facilitatory effects of respiration and voluntary contraction on cortical motor-evoked potentials of biceps or pectoral muscles were used to study CNS control over the reinnervated muscles. The time course of the facilitatory effect of respiration and voluntary contraction differed significantly. In the end stage of nerve regeneration, the facilitatory effect of voluntary contraction was significantly larger than that of respiration, indicating that the CNS control network over the muscle comes to resemble that of the recipient nerve (MCN or MPN) rather than that of the donor nerve (ICN). CONCLUSIONS:The strengthening of previously subthreshold synaptic connections in a CNS network connecting ICN to MCN or MPN neurons may underlie changing excitability.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Malessy MJ,Thomeer RT,van Dijk JG

doi

10.3171/jns.1998.89.4.0568

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

568-74

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

89

pub_type

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