Mathematical aspects of dose-response studies in carcinogenesis--the concept of thresholds.

Abstract:

:Many of the previously proposed theories of carcinogenesis which relate the exposure level of a carcinogen to expected tumor response, are summarized and it is pointed out that these theories assume the existence of no threshold level. A modification of the one-hit carcinogenic model which would incorporate a threshold, is proposed along with a generalization to variable thresholds over the population at risk. The statistical problems of discriminating between threshold and non-threshold models from experimental bioassay data are discussed and an example is given.

journal_name

Oncology

journal_title

Oncology

authors

Brown CC

doi

10.1159/000225106

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

62-5

issue

2

eissn

0030-2414

issn

1423-0232

journal_volume

33

pub_type

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