Abstract:
:All organisms must adapt to changing nutrient availability, with nutrient surplus promoting glucose metabolism and nutrient deficit promoting alternative fuels (in mammals, mainly free fatty acids). A major function of glucose-sensing neurons in the hypothalamus is to regulate blood glucose. When these neurons sense glucose levels are too low, they activate robust counterregulatory responses to enhance glucose production, primarily from liver, and reduce peripheral metabolism. Some hypothalamic neurons can metabolize free fatty acids via β-oxidation, and β-oxidation generally opposes effects of glucose on hypothalamic neurons. Thus hypothalamic β-oxidation promotes obese phenotypes, including enhanced hepatic glucose output.
journal_name
Endocrinol Metab Clin North Amjournal_title
Endocrinology and metabolism clinics of North Americaauthors
Moreno C,Yang L,Dacks P,Isoda F,Poplawski M,Mobbs CVdoi
10.1016/j.ecl.2012.11.007subject
Has Abstractpub_date
2013-03-01 00:00:00pages
67-80issue
1eissn
0889-8529issn
1558-4410pii
S0889-8529(12)00131-4journal_volume
42pub_type
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