Regulation of peripheral metabolism by substrate partitioning in the brain.

Abstract:

:All organisms must adapt to changing nutrient availability, with nutrient surplus promoting glucose metabolism and nutrient deficit promoting alternative fuels (in mammals, mainly free fatty acids). A major function of glucose-sensing neurons in the hypothalamus is to regulate blood glucose. When these neurons sense glucose levels are too low, they activate robust counterregulatory responses to enhance glucose production, primarily from liver, and reduce peripheral metabolism. Some hypothalamic neurons can metabolize free fatty acids via β-oxidation, and β-oxidation generally opposes effects of glucose on hypothalamic neurons. Thus hypothalamic β-oxidation promotes obese phenotypes, including enhanced hepatic glucose output.

authors

Moreno C,Yang L,Dacks P,Isoda F,Poplawski M,Mobbs CV

doi

10.1016/j.ecl.2012.11.007

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

67-80

issue

1

eissn

0889-8529

issn

1558-4410

pii

S0889-8529(12)00131-4

journal_volume

42

pub_type

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