Is there a place for "dose-dense" weekly schedules of the taxoids?

Abstract:

:The recommended weekly dose and the maximum tolerated weekly dose of docetaxel (Taxotere; Rhône-Poulenc Rorer, Antony, France) have yet to be determined. We report that a weekly dose of up to 40 mg/m2 docetaxel for 6 weeks is active in pretreated patients with metastatic breast cancer. From a preliminary study, this dose-dense schedule appears to induce less hematologic toxicity than a schedule of 100 mg/m2 every 3 weeks while achieving similar response rates and may represent a valuable alternative involving a shorter treatment time in the palliative therapy of advanced disease in higher-risk patients. The dose-dense weekly administration of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) also appears to be active, although the toxicity profiles of the two taxanes may differ.

journal_name

Semin Oncol

journal_title

Seminars in oncology

authors

Löffler TM

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

32-4

issue

5 Suppl 12

eissn

0093-7754

issn

1532-8708

journal_volume

25

pub_type

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