Spatial cone activity distribution in diseases of the posterior pole determined by multifocal electroretinography.

Abstract:

:Thirty patients with a reduced central vision due to diseases of the posterior pole were examined with the VERIS system developed by Sutter and Tran (Vis Res 1992;32:433-446) to characterize the topography of electroretinographic (ERG) changes in comparison to the results in 30 normal volunteers. Diagnoses included Stargardt's macular dystrophy (SMD, n = 10), age-related macular degeneration (AMD, n = 5), cone dystrophy (CD, n = 5), central retinal vein occlusion (CRVO, n = 5), and autosomal dominant optic atrophy (ADOA, n = 5). The 61 local responses obtained from each subjects were grouped by eccentricity to form five concentric rings. The foveal ERG, originating from a central area of 2 degrees radius, was non-recordable or markedly diminished in all patients except those with optic atrophy, where amplitudes were found to be in the normal range. In patients with advanced stages of SMD, functional defects were larger and involved more peripheral areas than in patients with early stages of SMD or with AMD. A reduction of response amplitude even in the most peripheral ring (17-30.5 degrees eccentricity) was found in cone dystrophies and--moderately--in patients with advanced SMD and central retinal vein occlusion only. Prolonged implicit times were found in all but the patients in early stages of SMD and they were maximal in patients with CRVO. This study shows that the multifocal ERG (MFERG) can contribute to differential diagnosis of retinal diseases of the posterior pole especially in cases with a normal photopic Ganzfeld ERG.

journal_name

Vision Res

journal_title

Vision research

authors

Kretschmann U,Seeliger M,Ruether K,Usui T,Zrenner E

doi

10.1016/s0042-6989(98)00071-6

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

3817-28

issue

23

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(98)00071-6

journal_volume

38

pub_type

杂志文章
  • The visual evoked potential in the mouse--origins and response characteristics.

    abstract::The visual evoked potential (VEP) in the mouse is characterized and compared to responses obtained with the electroretinogram (ERG). The results indicate that: 1, the VEP originates in the visual cortex; 2, the rod and cone pathways contribute separately to the VEP; 3, temporal tuning functions for rod and cone ERGs a...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2005.09.006

    authors: Ridder WH 3rd,Nusinowitz S

    更新日期:2006-03-01 00:00:00

  • Involuntary attention enhances identification accuracy for unmasked low contrast letters using non-predictive peripheral cues.

    abstract::There is controversy regarding whether or not involuntary attention improves response accuracy at a cued location when the cue is non-predictive and if these cueing effects are dependent on backward masking. Various perceptual and decisional mechanisms of performance enhancement have been proposed, such as signal enha...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2013.06.010

    authors: Pack W,Carney T,Klein SA

    更新日期:2013-08-30 00:00:00

  • Temporal frequency limits for stereoscopic apparent motion processes.

    abstract::Temporal processing limits were determined for two types of stereoscopic percept associated with square wave disparity alternation: apparent depth motion and depth pulsation. The stimuli were dynamic random dot stereograms containing no monocular cues for either target motion or disparity change. The percept of a sing...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(84)90037-3

    authors: Norcia AM,Tyler CW

    更新日期:1984-01-01 00:00:00

  • Spatial primes produce dissociated inhibitory effects on saccadic latencies and trajectories.

    abstract::In masked priming, a briefly presented prime can facilitate or inhibit responses to a subsequent target. In most instances, targets with an associated response that is congruent with the prime direction speed up reaction times to the target (a positive compatibility effect; PCE). However, under certain circumstances, ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2013.12.017

    authors: Misirlisoy E,Hermens F,Stavrou M,Pennells J,Walker R

    更新日期:2014-03-01 00:00:00

  • Differential spatial displacement discrimination thresholds for Gabor patches.

    abstract::Differential spatial displacement discrimination thresholds were determined for a configuration of three identical Gaussian modulated patches of sinusoidal grating presented with equal orientation and at threshold luminance contrast. The patches were arranged one above the other at equal spatial intervals. The orienta...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:

    authors: Toet A,Koenderink JJ

    更新日期:1988-01-01 00:00:00

  • Individual differences in sensory eye dominance reflected in the dynamics of binocular rivalry.

    abstract::Normal binocular vision emerges from the combination of neural signals arising within separate monocular pathways. It is natural to wonder whether both eyes contribute equally to the unified cyclopean impression we ordinarily experience. Binocular rivalry, which occurs when the inputs to the two eyes are markedly diff...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2016.09.014

    authors: Dieter KC,Sy JL,Blake R

    更新日期:2017-12-01 00:00:00

  • Numbers and ratios of X-chromosomal-linked opsin genes.

    abstract::Quantitative Southern blotting and PCR/RFLP analysis were used to determine the number and ratio of long-wave-sensitive (L-) and mid-wave-sensitive (M-) opsin genes in 25 colour-normal caucasian males. The average observed ratio was 1:2.8 +/- 1.2 for Southern blot analysis and 1:3.0 +/- 1.7 for PCR/RFLP analysis. Thus...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(98)00077-7

    authors: Wolf S,Sharpe LT,Knau H,Wissinger B

    更新日期:1998-11-01 00:00:00

  • Visual following during stimulation of an immobile eye (the open loop condition).

    abstract::We had the rare opportunity to examine a patient with a unilateral complete ophthalmoplegia in an eye with normal visual acuity. We recorded the movements of the covered, sound eye of the patient during full-field optokinetic stimulation of his seeing, immobile eye (open loop condition). The open loop gain for low vel...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(82)90084-0

    authors: Leigh RJ,Newman SA,Zee DS,Miller NR

    更新日期:1982-01-01 00:00:00

  • A simple mechanism for detecting low curvatures.

    abstract::We measured thresholds for detecting the direction of curvature in slightly bent stimuli such as arcs and sinusoidal lines, and the direction of bend in chevrons and trapezoids in an initial experiment. Stimulus length varied over a wide range from 8.3 to 267 min arc. For sufficiently long stimuli, the angle between t...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(95)00340-1

    authors: Kramer D,Fahle M

    更新日期:1996-05-01 00:00:00

  • Visual pigments and environmental light.

    abstract::The visual pigments in the rods do not have a special absorption that gives them maximal sensitivity. The visual pigments of "deep sea" fish are an exception for these do match the environmental light to give maximum sensitivity. At the low light intensities at which the rods operate, it is the number of photons that ...

    journal_title:Vision research

    pub_type: 杂志文章,评审

    doi:10.1016/s0042-6989(84)80003-6

    authors: Lythgoe JN

    更新日期:1984-01-01 00:00:00

  • Intraocular light scatter in patients with retinitis pigmentosa.

    abstract::We evaluated the level of intraocular light scatter in a group of patients with retinitis pigmentosa (RP) who had minimal or no lens opacities, since such patients not infrequently complain of photoaversion. Intraocular light scatter was measured in 20 patients with RP who were < 60 years of age and who had no more th...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(96)00068-5

    authors: Alexander KR,Fishman GA,Derlacki DJ

    更新日期:1996-11-01 00:00:00

  • Role of motion integration in contour perception.

    abstract::Contours are believed to play a key role in the visual analysis of scenes by the primate brain. In dynamic scenes, the presence of contours is often signaled by discontinuities in motion fields. However, it is unclear whether the motion fields over which the visual system extracts discontinuities, correspond to the lo...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(00)00306-0

    authors: Sinha P

    更新日期:2001-03-01 00:00:00

  • Influence of reading skill and word length on fixation-related brain activity in school-aged children during natural reading.

    abstract::Word length is one of the main determinants of eye movements during reading and has been shown to influence slow readers more strongly than typical readers. The influence of word length on reading in individuals with different reading skill levels has been shown in separate eye-tracking and electroencephalography stud...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2019.07.008

    authors: Loberg O,Hautala J,Hämäläinen JA,Leppänen PHT

    更新日期:2019-12-01 00:00:00

  • Exogenous attention and color perception: performance and appearance of saturation and hue.

    abstract::Exogenous covert attention is an automatic, transient form of attention that can be triggered by sudden changes in the periphery. Here we test for the effects of attention on color perception. We used the methodology developed by Carrasco, Ling, and Read [Carrasco, M., Ling, S., & Read, S. (2004). Attention alters app...

    journal_title:Vision research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.visres.2006.07.014

    authors: Fuller S,Carrasco M

    更新日期:2006-11-01 00:00:00

  • Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration.

    abstract::The foveal region of the retina has a yellow pigmentation composed primarily of the carotenoids lutein and zeaxanthin. Past studies have shown that cigarette smoking depresses carotenoid concentrations in the blood. This is the first report on the effects of cigarette smoking on carotenoids in the retina. Macular pigm...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(96)00008-9

    authors: Hammond BR Jr,Wooten BR,Snodderly DM

    更新日期:1996-09-01 00:00:00

  • The effect of perceived distance on accommodation under binocular steady-state conditions.

    abstract::Spatiotopic cues, such as perceived distance, have little effect on accommodation unless blur has been reduced or eliminated. We investigated the effect of perceived distance on accommodation under binocular steady-state conditions, about which little is known. Blur was reduced but not eliminated by using a stimulus w...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(94)00157-h

    authors: Kotulak JC,Morse SE

    更新日期:1995-03-01 00:00:00

  • Evoked potentials elicited by brief vernier offsets: estimating vernier thresholds and properties of the neural substrate.

    abstract::The characteristics of the neural generator producing an evoked potential in response to the brief presentation of a vernier offset was investigated in three experiments. In the first study, averaged evoked potentials (EPs) recorded in response to a single vernier offset stimulus consisting of a horizontal line which ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(86)90187-2

    authors: Zak R,Berkley MA

    更新日期:1986-01-01 00:00:00

  • Cultural influences on oculomotor inhibition of remote distractors: evidence from saccade trajectories.

    abstract::This study investigated whether low-level attentional processes as indicated by saccade trajectories are modulated by higher-order factors as indicated by participants' cultural background. We hypothesized that if the East Asian participants engage in context-dependent attentional processing to a greater extent than t...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2013.03.008

    authors: Petrova K,Wentura D,Fu X

    更新日期:2013-05-24 00:00:00

  • Characterization of glutamate transporter function in the tiger salamander retina.

    abstract::Glutamate transporters in the tiger salamander retina were studied by autoradiographic and intracellular recording techniques. When the retina was incubated with 15 microM L-[3H]glutamate, photoreceptors and Muller cells were labeled, indicating that these cells had high-affinity glutamate uptake transporters. A much ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(96)00231-3

    authors: Yang JH,Wu SM

    更新日期:1997-04-01 00:00:00

  • Mechanisms underlying the anisotropy of stereoscopic tilt perception.

    abstract::There is a marked anisotropy in the perception of stereoscopic tilt: vertical gradients of horizontal disparity are more easily perceived than horizontal gradients. This could be explained if orientation disparity (the orientation difference in the two eyes' views of the same line) were one of the cues used to determi...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(90)90159-i

    authors: Mitchison GJ,McKee SP

    更新日期:1990-01-01 00:00:00

  • Electrophysiological correlates of positive and negative afterimages.

    abstract::We report here measurements of visual evoked potential (VEP) activity after induction of afterimages in human observers. Drifting gratings normally produce no measurable phase synchronized VEP. However, after an afterimage of a high contrast grating of the same orientation and spatial frequency of that of the drifting...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(87)90182-9

    authors: Burr DC,Fiorentini A,Morrone MC

    更新日期:1987-01-01 00:00:00

  • Infant interocular acuity differences and binocular vision.

    abstract::Monocular acuity, binocular acuity, and stereopsis were assessed with preferential-looking techniques in a sample of 114 normal infants aged 0-11 months in order to examine developmental trends in: (1) interocular differences in acuity, (2) test-retest reliability, (3) the relationship between monocular and binocular ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(85)90162-2

    authors: Birch EE

    更新日期:1985-01-01 00:00:00

  • Adaptation to objects in the lateral occipital complex (LOC): shape or semantics?

    abstract::A change in the basic-level class when viewing a sequence of two objects produces a large release from adaptation in LOC compared to when the images are identical. Is this due to a change in semantics or shape? In an fMRI-adaptation experiment, subjects viewed a sequence of two objects and judged whether the stimuli w...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2009.06.020

    authors: Kim JG,Biederman I,Lescroart MD,Hayworth KJ

    更新日期:2009-09-01 00:00:00

  • Psychophysics of reading. XVIII. The effect of print size on reading speed in normal peripheral vision.

    abstract::Reading in peripheral vision is slow and requires large print, posing substantial difficulty for patients with central scotomata. The purpose of this study was to evaluate the effect of print size on reading speed at different eccentricities in normal peripheral vision. We hypothesized that reading speeds should remai...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(98)00072-8

    authors: Chung ST,Mansfield JS,Legge GE

    更新日期:1998-10-01 00:00:00

  • Disconjugate adaptation of saccades: contribution of binocular and monocular mechanisms.

    abstract::We studied the effects of prism-induced disparity on static and intrasaccadic alignment in six normal human subjects. A ten diopter base-out prism, calling for convergence, was placed in front of the central field of the right eye, so that at the center the eye viewed through the prism; at left and right, outside the ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(98)00156-4

    authors: Averbuch-Heller L,Lewis RF,Zee DS

    更新日期:1999-01-01 00:00:00

  • Impoverished second-order input to global linking in human vision.

    abstract::Recent evidence points to the importance of global operations across spatial regions larger than individual cortical receptive fields. Studies of contour integration and motion trajectory detection suggest that network operations between local detectors underlie the encoding of extended contours in space and extended ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/s0042-6989(00)00183-8

    authors: Hess RF,Ledgeway T,Dakin S

    更新日期:2000-01-01 00:00:00

  • Brightness matching and flicker photometric data obtained over the full mesopic range.

    abstract::Three normal observers made visual matches from 0.03 to 100 td on a 10 degree central field at 445, 560 and 630 nm, using two different methods: heterochromatic flicker photometry and direct comparison brightness matching. In a relative sensitivity vs illuminance plot, the brightness matches underwent smooth changes, ...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(92)90245-e

    authors: Vienot F,Chiron A

    更新日期:1992-03-01 00:00:00

  • Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice.

    abstract::In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the cont...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/j.visres.2007.02.011

    authors: Aldrovani M,Guaraldo AM,Vidal BC

    更新日期:2007-12-01 00:00:00

  • Accommodative microfluctuations and pupil diameter.

    abstract::The nominally steady-state accommodation response exhibits temporal variations which can be characterized by two dominant regions of activity; a low frequency component (LFC < 0.6 Hz) and a high frequency component (1.0 < or = HFC < or = 2.1 Hz). There is no consensus as to the relative contribution made by each of th...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(93)90007-j

    authors: Gray LS,Winn B,Gilmartin B

    更新日期:1993-10-01 00:00:00

  • Binocular interactions in rapid saccadic adaptation.

    abstract::An adaptive mechanism controls the strength of innervation to the two eyes independently. However, under some circumstances an adjustment in strength of innervation to one eye is generalized to the other. The coupling and uncoupling of the two eyes during saccadic motor learning was studied using the technique of intr...

    journal_title:Vision research

    pub_type: 杂志文章

    doi:10.1016/0042-6989(95)00079-t

    authors: Albano JE,Marrero JA

    更新日期:1995-12-01 00:00:00