Abstract:
:Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Benders KE,van Weeren PR,Badylak SF,Saris DB,Dhert WJ,Malda Jdoi
10.1016/j.tibtech.2012.12.004subject
Has Abstractpub_date
2013-03-01 00:00:00pages
169-76issue
3eissn
0167-7799issn
1879-3096pii
S0167-7799(12)00223-5journal_volume
31pub_type
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