Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

Abstract:

:Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Additionally, cancer progression may be partly regulated by CBR1. In the present study, we screened more than 10 drugs for the induction of the human CBR1 gene to investigate its regulation. Of the drugs, butylated hydroxyanisole (BHA) was found to be an inducer. BHA induced the mRNA and protein expression of CBR1 in hepatoma HepG2 cells. In a luciferase reporter gene assay, the promoter region between -2062 bp and the transcription start site of CBR1 was also activated by BHA. The transcription factor Nrf2 is known to be activated by BHA. There are 2 anti-oxidant responsive elements (ARE) that are bound by Nrf2 in this region. Mutation analyses revealed that one of the AREs participates in the gene regulation of CBR1 by Nrf2. Electrophoretic mobility shift assay revealed that Nrf2 binds the site. Moreover, to determine whether the functional ARE of CBR1 is conserved with the promoter region of homologues in other species, the nucleotide sequences of the functional AREs of the Chcr1 and Chcr2 genes, which are the Chinese hamster homologues of CBR1, were determined. The region has 2 AREs, and these genes were also induced by the forced expression of Nrf2 (cotransfection of pNrf2) in the luciferase reporter gene assay. In conclusion, Nrf2 is a novel transcriptional regulator of CBR1 genes in humans and the Chinese hamster. Because the regulation of CBR1 appears to be important for diseases, the induction of CBR1 by Nrf2 may be a therapeutic target.

journal_name

Chem Biol Interact

authors

Miura T,Taketomi A,Nishinaka T,Terada T

doi

10.1016/j.cbi.2012.11.023

subject

Has Abstract

pub_date

2013-02-25 00:00:00

pages

126-35

issue

1-3

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(12)00267-0

journal_volume

202

pub_type

杂志文章
  • Partial inhibition of the P-glycoprotein-mediated transport of anthracyclines in viable resistant K562 cells after irradiation in the presence of a verapamil analogue.

    abstract::P-glycoprotein (P-gp) is a membranous ATPase responsible for the multidrug resistance phenotype. The effect on P-gp-mediated transport of anthracyclines of cell irradiation in the presence of 2,2-diphenyl-5-[N-1-(o-azidophenyl)ethylamino]valeronitrile (VP*), a photoactivable analogue of verapamil was studied in viable...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(99)00095-2

    authors: Mankhetkorn S,Teodori E,Garnier-Suillerot A

    更新日期:1999-07-01 00:00:00

  • Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat.

    abstract::Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for the first time that therapeutic interventio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.10.009

    authors: Rani V,Verma Y,Rana K,Rana SVS

    更新日期:2018-11-01 00:00:00

  • Cytochrome P450 mediated metabolic activation of chrysophanol.

    abstract::Chrysophanol, a major anthraquinone component occurring in many traditional Chinese herbs, is accepted as important active component with various pharmacological actions such as antibacterial and anticancer activity. Previous studies demonstrated that exposure to chrysophanol induced cytotoxicity, but the mechanisms o...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.04.015

    authors: Sun Y,Xin X,Zhang K,Cui T,Peng Y,Zheng J

    更新日期:2018-06-01 00:00:00

  • An overview of published benzene exposure data by industry in China, 1960-2003.

    abstract::This article presents an overview of occupational benzene exposures in China based on data published in Chinese medical journals. The data were derived from 384 reports of benzene poisoning or industrial hygiene surveys published in Chinese medical journals between 1960 and 2003. The following information was extracte...

    journal_title:Chemico-biological interactions

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.cbi.2005.03.009

    authors: Liang YX,Wong O,Armstrong T,Ye XB,Miao LZ,Zhou YM,Wu QE,Qian HJ,Fu H

    更新日期:2005-05-30 00:00:00

  • Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity.

    abstract::The present study shows the existence of both Ca2+-dependent and EDTA-resistant hydrolysing activities against HDCP and paraoxon in the particulate and soluble fractions of hen, rat and rabbit liver. HDCP was more extensively hydrolysed than paraoxon in both subcellular fractions and each of three individuals of the t...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(99)00035-6

    authors: Monroy-Noyola A,Sogorb MA,Díaz-Alejo N,Níguez N,Barril J,Vicedo JL,Escudero MA,Vilanova E

    更新日期:1999-05-14 00:00:00

  • Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells.

    abstract::Cataract is the most frequent cause of blindness worldwide and is treated by surgical removal of the opaque lens to restore the light path to the retina. While cataract surgery is a safe procedure, some patients develop a complication of the surgery involving opacification and wrinkling of the posterior lens capsule. ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.01.017

    authors: Chang KC,Shieh B,Petrash JM

    更新日期:2017-10-01 00:00:00

  • Kinetic studies of the hydrolysis of platinum-DNA complexes by nuclease S1.

    abstract::The antitumor agent cis-diamminedichloroplatinum(II) (cis-DDP) reacts covalently with DNA and disrupts its secondary structure. Damaged DNA, but not native DNA, is readily digested by S1 nuclease, an endonuclease specific for single stranded polynucleotides. We have measured S1 nuclease digestion of platinated DNA by ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(90)90003-6

    authors: Butour JL,Mazard AM,Vieussens C,Johnson NP

    更新日期:1990-01-01 00:00:00

  • Immunological properties of low molecular-weight proteins binding heavy metals in rat kidney and liver.

    abstract::Two homogenous fractions of hepatic metallothioneins ((Cd,Zn) MT-1 and (Cd,Zn) MT-2) and renal metal binding proteins ((Bi,Cu) BP-1 and (Bi,Cu) BP-2) were isolated from rats exposed to heavy metals and specific antisera to them were produced in rabbits. These antisera were tested by immunodiffusion and immunoelectroph...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(80)90048-4

    authors: Zelazowski AJ,Szymańska JA,Cierniewski CS

    更新日期:1980-12-01 00:00:00

  • Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption.

    abstract::The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases. Previous studies have reported polyphosphate (PolyP)-mediated vascular inflammatory responses such as disruption of vascular integrity. Dabrafenib is a B-Raf...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.07.024

    authors: Lee S,Ku SK,Bae JS

    更新日期:2016-08-25 00:00:00

  • In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).

    abstract::Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. The cytostat...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.04.002

    authors: Karthik R,Manigandan V,Ebenezar KK,Vijayashree R,Saravanan R

    更新日期:2017-06-25 00:00:00

  • Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences.

    abstract::Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal enzymes responsible for metabolism of ethanol. Both ADH and ALDH exhibit genetic polymorphisms among racial populations. Functional variant alleles ADH1B*2 and ALDH2*2 have been consistently replicated to show protection against developing...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2008.10.029

    authors: Chen YC,Peng GS,Wang MF,Tsao TP,Yin SJ

    更新日期:2009-03-16 00:00:00

  • Carboxylesterases: General detoxifying enzymes.

    abstract::Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding alcohol and carboxylic acid. To date, no endogenous CE substrates have been identified and as such, these proteins are thought to act as a m...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2016.02.011

    authors: Hatfield MJ,Umans RA,Hyatt JL,Edwards CC,Wierdl M,Tsurkan L,Taylor MR,Potter PM

    更新日期:2016-11-25 00:00:00

  • Trikatu, an herbal compound ameliorates rheumatoid arthritis by the suppression of inflammatory immune responses in rats with adjuvant-induced arthritis and on cultured fibroblast like synoviocytes via the inhibition of the NFκB signaling pathway.

    abstract::The present study was designed to investigate the potential therapeutic effect of trikatu, an herbal compound and its underlying molecular mechanism in rats with adjuvant-induced arthritis (AIA). Our results indicate that trikatu (1000 mg/kg/b.wt. oral) administration suppressed the production of pro-inflammatory cyto...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.09.003

    authors: Doss HM,Ganesan R,Rasool M

    更新日期:2016-10-25 00:00:00

  • 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.

    abstract::20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.11.008

    authors: Lu C,Dong L,Lv J,Wang Y,Fan B,Wang F,Liu X

    更新日期:2018-01-05 00:00:00

  • Role of ELAV-like RNA-binding proteins HuD and HuR in the post-transcriptional regulation of acetylcholinesterase in neurons and skeletal muscle cells.

    abstract::Over the last few years, several laboratories have focused their attention on elucidating the molecular events that control the expression and localization of acetylcholinesterase (AChE) in neurons and skeletal muscle cells. In this context, results from a number of studies have clearly shown the important contributio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2005.10.004

    authors: Deschênes-Furry J,Angus LM,Bélanger G,Mwanjewe J,Jasmin BJ

    更新日期:2005-12-15 00:00:00

  • Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.

    abstract::The present study was an attempt to investigate the hepatoprotective and antioxidative property of Phyllanthus amarus (P. amarus) extract and phyllanthin. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient eluti...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2009.06.014

    authors: Krithika R,Mohankumar R,Verma RJ,Shrivastav PS,Mohamad IL,Gunasekaran P,Narasimhan S

    更新日期:2009-10-30 00:00:00

  • Increased metallothionein gene expression in 5-aza-2'-deoxycytidine-induced resistance to cadmium cytotoxicity.

    abstract::The pyrimidine analog, 5-azacytidine (AZA-CR), has been shown to increase the expression of the metallothionein (MT) gene and to induce tolerance to cadmium toxicity. Since incorporation into DNA of AZA-CR appears to be required for this effect, the deoxynucleoside of AZA-CR should also be effective. Therefore, this s...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(88)90071-3

    authors: Waalkes MP,Miller MS,Wilson MJ,Bare RM,McDowell AE

    更新日期:1988-01-01 00:00:00

  • Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industry.

    abstract::This study evaluated relations between exposure to 1,3-butadiene (BD), styrene (STY) and dimethyldithiocarbamate (DMDTC) and mortality from leukemia among synthetic rubber industry workers. Subjects were 13130 men employed for at least 1 year during 1943-1991 at any of six plants that manufactured synthetic rubber. De...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(01)00223-x

    authors: Delzell E,Macaluso M,Sathiakumar N,Matthews R

    更新日期:2001-06-01 00:00:00

  • Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.

    abstract::Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed bone nodule formatio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.01.039

    authors: Sun K,Mei W,Mo S,Xin L,Lei X,Huang M,Chen Q,Han L,Zhu X

    更新日期:2019-04-25 00:00:00

  • DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine. A sulfhydryl metabolite of levamisole that interacts with microtubules.

    abstract::DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine (OMPI) a sulfhydryl metabolite of levamisole, unlike the parent compound, is shown to interfere with the morphological and functional integrity of microtubules in cultured cells at high concentrations (1.6-10(-4) M). Lower concentrations do not affect the cell morphol...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(78)90041-8

    authors: De Brabander M,Aerts F,Geuens G,van Ginckel R,van de Veire R,van Belle H

    更新日期:1978-10-01 00:00:00

  • Effect of aflatoxins on oxidative phosphorylation by rat liver mitochondria.

    abstract::The in vitro effect of aflatoxins M1, B1 and G1 on oxidative phosphorylation by rat liver mitochondria with succinate as substrate has been studied. All these toxins inhibit the electron transport chain at a 1-10-4 M concentration and the site of inhibition is between cytochrome b and cytochrome c or c1. Aflatoxin M1 ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(75)90106-4

    authors: Ramachandra Pai M,Jayanthi Bai N,Venkitasubramanian TA

    更新日期:1975-02-01 00:00:00

  • Cancer risk assessment for 1,3-butadiene: dose-response modeling from an epidemiological perspective.

    abstract::The dose-response assessment of the association between 1,3-butadiene (BD) and leukemia mortality among workers in the North American synthetic rubber industry is explored. Analyses are based on the most recent University of Alabama at Birmingham epidemiological study and exposure estimation. The U.S. EPA Science Advi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2006.06.004

    authors: Sielken RL Jr,Valdez-Flores C,Gargas ML,Kirman CR,Teta MJ,Delzell E

    更新日期:2007-03-20 00:00:00

  • Metabolism of 1-nitropyrene in mice: transport across the placenta and mammary tissues.

    abstract::The distribution and metabolism of the environmental pollutant 1-nitropyrene was studied in C57B1/6N mice following oral or intraperitoneal dosing. When administered by gavage, 1-nitropyrene and its metabolites demonstrated biphasic elimination kinetics from the blood, with half-lives of 0.3 and 1.8 days and a distrib...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(94)03574-r

    authors: Howard PC,Consolo MC,Dooley KL,Beland FA

    更新日期:1995-04-14 00:00:00

  • The time course of DNA repair following methyl nitro-nitrosoguanidine (MNNG) treatment of p388f lymphoma cells in culture. II. DNA repair synthesis and its correlation with strand breakage.

    abstract::Repair synthesis has been followed in P388F cell DNA following treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) using 5-iodo-deoxyuridine (IUdR) and [3H] thymidine combination. A pattern of repair synthesis was obtained, similar in its timing to the initial and medial stages of single-strand break formation ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(76)90023-5

    authors: Nikaido O,Fox BW

    更新日期:1976-07-01 00:00:00

  • pH effects on the N-demethylation and formation of the cytochrome P-450 iron II nitrosoalkane complex for erythromycin derivatives.

    abstract::The effects of pH on access to the cytochrome P-450 active site, N-demethylation and formation of the cytochrome P-450 Fe(II)-RNO metabolite complex for a series of erythromycin derivatives were examined. Studies were performed with dexamethasone-treated rat liver microsomes containing large amounts of cytochrome P-45...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(92)90063-q

    authors: Delaforge M,Ladam P,Bouillé G,Benarous JG,Jaouen M,Girault JP

    更新日期:1992-12-01 00:00:00

  • Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue.

    abstract::Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminoglycoside, is reported to cause lipid peroxidation. We focused on lipid ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2004.05.005

    authors: Yanagida C,Ito K,Komiya I,Horie T

    更新日期:2004-07-20 00:00:00

  • Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice.

    abstract::Vitamin A-deficient male mice were treated for 10 days with 0.02% perfluorooctanoic acid (PFOA) in their diet. The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1-7.5 times in comparison to the values obtained with mice...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(95)03630-5

    authors: Sohlenius AK,Andersson K,Olsson J,DePierre JW

    更新日期:1995-10-20 00:00:00

  • Nitrative modifications of α-enolase in hepatic proteins from diabetic rats: the involvement of myeloperoxidase.

    abstract::Many studies reported that oxidative and nitrative stress might be important in the pathogenesis of diabetes and the development of its complications. In this study, we showed that α-enolase (EC 4.2.1.11, 2-phospho-d-glycerate hydrolase) was identified as the important target for oxidative and nitrative modifications ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2014.05.021

    authors: Lu N,Li J,He Y,Tian R,Xiao Q

    更新日期:2014-09-05 00:00:00

  • Dosimetry of glycidyl ethers in mice by quantification of haemoglobin adducts.

    abstract::Glycidyl ethers are used in epoxy resins. Epoxy resins are widely used in adhesives and coatings, as well as in electronics and structural composites, thus there is a potential of human exposure to glycidyl ethers. The aim of the present investigation was to explore the utility of haemoglobin adducts for biomonitoring...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(96)03744-1

    authors: Pérez HL,Plná K,Osterman-Golkar S

    更新日期:1997-01-24 00:00:00

  • Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin αvβ3 pathway.

    abstract::Excessive osteoclast leads to the imbalance in bone reconstruction and results in osteolytic diseases, such as osteoporosis and rheumatic arthritis. Integrin αvβ3 abundantly expresses on osteoclast and plays a critical role in the formation and function of osteoclast, therefore, blockage of αvβ3 has become an attracti...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109179

    authors: Zeng Q,Lu W,Deng Z,Wu J,Guo R,Xu X

    更新日期:2020-08-25 00:00:00