The energetic significance of lactate accumulation in blood at altitude.

Abstract:

:The O2 equivalent of lactic acid accumulation in blood was estimated from data on ten subjects acclimatized to altitudes up to 6500 m in the course of a Mt. Everest expedition. The calculated value of the O2 equivalent of La by standard least squares regression was 2.07 +/- 0.4 l O2 for a rise of blood lactic acid concentration [Lab] of 1 g per liter of blood (2.92 ml O2 per kg of body weight per 1 mM increase in blood lactate). This value, as well as the value obtained by the regression procedure suggested by Brace (2.84 +/- 0.5 l), was not significantly different from the previously reported value of 2.38 +/- 0.22 (14) for sea-level conditions. This finding indicated that, after La equilibrium is achieved, the redistribution of La among extra- and intracellular body compartments, as reflected by [Lab], appears not to be substantially affected by chronic hypoxia. The calculated maximum lactic O2 debt values at the Mt. Everest base camp (5350 m) were 1.26 and 1.42 liters for acclimatized Caucasians and for Sherpas, respectively. The amount of the measured maximum O2 debt at altitude was somewhat increased by pure O2 breathing (1.53 vs 1.26 l).

journal_name

Int J Sports Med

authors

Cerretelli P,Binzoni T

doi

10.1055/s-2007-1024850

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

S27-30

eissn

0172-4622

issn

1439-3964

journal_volume

11 Suppl 1

pub_type

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