Abstract：
PURPOSE:Deficiencies in placental catechol-O-methyltransferase (COMT) and circulating 2-methoxyoestradiol (2-ME) have been shown to be related to early onset preeclampsia. The aim of this study was to investigate levels of 2-ME in the serum and urine of patients with late-onset preeclampsia and to compare those levels to those of normal pregnant women. In addition, we examined placental COMT expression in both groups. METHODS:Fifteen patients with preeclampsia and 15 normal pregnant women were enrolled. 2-ME levels were evaluated by ELISA and placental COMT expression was examined by Western blot analysis. RESULTS:2-ME levels in serum [median 181.1 pg/mL, interquartile range (IQR) 119.6-244.3 vs. 61.2 pg/mL, IQR 12.0-133.7, respectively, p = 0.004] and urine (median 143.3 pg/mL, IQR 35.0-328.2 vs. 0.5 pg/mL, IQR 0.4-4.6, respectively, p < 0.001) were significantly increased in patients with late-onset preeclampsia compared to those in normal pregnant women at term. There was no significant difference in placental COMT expression between the two groups. CONCLUSION:Increased levels of 2-ME in patients with late-onset preeclampsia might be a product of a compensatory mechanism in patients with late-onset preeclampsia.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Seol HJ,Cho GJ,Oh MJ,Kim HJdoi
10.1007/s00404-012-2663-1subject
Has Abstractpub_date
2013-05-01 00:00:00pages
881-6issue
5eissn
0932-0067issn
1432-0711journal_volume
287pub_type
杂志文章abstract：:Samples of 40 endometrial carcinomas were examined by immunohistochemical methods for CA19-9, CA125 and CEA. CA19-9 was detected in 93%, CA125 in 65% and CEA in 58%. CA19-9 was detected in more than 50% of tumor cells in 14 cases and the same was true for CA125 in six cases. In no tumor was CEA found in more than half...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF00931402
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:This study is designed to explore the correlation between AMH levels and IR in normal weight PCOS women. MATERIALS AND METHODS:This prospective study was conducted on 55 patients, who were admitted to obstetrics and gynecology department of a university clinic. Study group was consisted of 34 patients diagnose...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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abstract：OBJECTIVE:Case report of a rare combination of a trisomy 18 and 21 in a dizygotic twin pregnancy in a woman with a history of recurrent miscarriage, a neonatal death, no living offspring and Graves disease. METHODS:Case report and literature search. RESULTS:Only one other report in the literature of a combined trisom...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0378-5
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abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF01370929
更新日期：1996-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05755-4
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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abstract：INTRODUCTION:Breast reconstruction with salpingo-oophorectomy can easily be performed in patients with genetic mutations increasing the risk for mammary and ovarian carcinoma. However, many patients are skeptical about having several surgeries, as they may result in additional anesthesiological risks as well as multipl...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-3133-0
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-012-2397-0
更新日期：2012-10-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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更新日期：2011-07-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0683-1
更新日期：2005-02-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02417572
更新日期：1989-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0557-4
更新日期：2008-09-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2972-z
更新日期：2014-02-01 00:00:00
abstract：:Cervical endometriosis is usually a retrospective finding on histology. We describe the diverse symptomatology of the disease, wherein a suspicion of diagnosis may be raised. A series of five patients with cervical endometriosis confirmed on histology was identified. One patient was asymptomatic but examination reveal...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-005-0006-1
更新日期：2005-10-01 00:00:00
abstract：AIM:In order to assess the responsiveness of short forms of the Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6) in a subset of women undergoing radical operations for gynecologic cancer. MATERIALS AND METHODS:Women with cervical cancer without any abnormal urodynamic abnormalities w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1823-4
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Epidemiological studies have provided controversial evidence of an association between alcohol intake and endometrial cancer (EC) risk. The World Cancer Research Fund/American Institute for Cancer Research classifies alcohol as having a "limited-no conclusion" grade of evidence in the Endometrial Cancer 2013...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1982-y
更新日期：2012-02-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-001-0255-6
更新日期：2002-11-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4917-z
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:Morbid obesity is perhaps the most common nutritional disorder seen in pregnancy, and morbidly obese parturients have more pregnancy complication than normal body mass index (BMI) pregnant patients. Combined spinal epidural anesthesia (CSEA) has become a well-established alternative to epidural analgesia f...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0634-x
更新日期：2005-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02718276
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To evaluate at 11-13 weeks' gestation biochemical markers that may predict complications of pregnancy such as pre-eclampsia, proteinuria, and hypertension. METHODS:Analyses were performed on first-morning urine and plasma samples from first trimester pregnant women with increased risk of developing pre-eclamps...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-016-4111-0
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To investigate the efficacy of bupivacaine-soaked spongostan in cesarean section wound for postoperative anxiety level, satisfaction and early postpartum depression rate. METHODS:A total of 121 women, American Society of Anesthesiologists physical status I-II, scheduled to undergo general anesthesia and electi...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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更新日期：2014-08-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-003-0593-7
更新日期：2004-05-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1228-4
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Osteogenesis imperfecta (OI) is a rare heritable heterogenous disorder characterized by bone fragility and susceptibility to fractures with a wide spectrum of clinical expression due to defects in collagen type I biosynthesis. The purpose of the review is to highlight the practical norms in pregnancies with ost...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
