CXCR4(+) dendritic cells promote angiogenesis during embryo implantation in mice.

abstract：INTRODUCTION:Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs) to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes lead to the inherited vascular disorder hereditary haemorrhagic telangiectasia (HHT), characterised by arteriovenous malformations (AVMs). Howev...

journal_title：Angiogenesis

authors： Singh E,Redgrave RE,Phillips HM,Arthur HM

更新日期：2020-11-01 00:00:00

abstract：:Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...

journal_title：Angiogenesis

authors： Gianni-Barrera R,Trani M,Fontanellaz C,Heberer M,Djonov V,Hlushchuk R,Banfi A

更新日期：2013-01-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：:Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid...

journal_title：Angiogenesis

authors： Le Cras TD,Mobberley-Schuman PS,Broering M,Fei L,Trenor CC 3rd,Adams DM

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...

journal_title：Angiogenesis

authors： Harfouche R,Basu S,Soni S,Hentschel DM,Mashelkar RA,Sengupta S

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...

journal_title：Angiogenesis

authors： Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

更新日期：2020-05-01 00:00:00

abstract：:Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into ph...

journal_title：Angiogenesis

authors： Núñez-Gómez E,Pericacho M,Ollauri-Ibáñez C,Bernabéu C,López-Novoa JM

更新日期：2017-02-01 00:00:00

abstract：:Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...

journal_title：Angiogenesis

authors： Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Angiogenesis plays a pivotal role in neoplastic growth and metastasis formation. Vascular endothelial growth factor A (VEGFA) is a major player in physiological and tumour-induced angiogenesis and numerous human tumours have been show to overexpress VEGFA. Moreover increased VEGFA gene expression has been fo...

journal_title：Angiogenesis

authors： Andreozzi M,Quagliata L,Gsponer JR,Ruiz C,Vuaroqueaux V,Eppenberger-Castori S,Tornillo L,Terracciano LM

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:EPLIN (epithelial protein lost in neoplasm) is a cytoskeletal associated protein involved in the regulation of actin dynamics and subsequently in cell motility. EPLIN expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer ce...

journal_title：Angiogenesis

authors： Sanders AJ,Ye L,Mason MD,Jiang WG

更新日期：2010-12-01 00:00:00

abstract：:Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promisi...

journal_title：Angiogenesis

authors： Bocci M,Sjölund J,Kurzejamska E,Lindgren D,Marzouka NA,Bartoschek M,Höglund M,Pietras K

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...

journal_title：Angiogenesis

authors： Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

更新日期：2016-04-01 00:00:00

abstract：:Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular pathways preventing subretinal vascularization remain largely unknown. In...

journal_title：Angiogenesis

authors： Niaudet C,Petkova M,Jung B,Lu S,Laviña B,Offermanns S,Brakebusch C,Betsholtz C

更新日期：2019-11-01 00:00:00

abstract：:Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

journal_title：Angiogenesis

authors： Masiero L,Figg WD,Kohn EC

更新日期：1997-01-01 00:00:00

abstract：:Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...

journal_title：Angiogenesis

authors： Decaris ML,Lee CI,Yoder MC,Tarantal AF,Leach JK

更新日期：2009-01-01 00:00:00

abstract：:Vascularization and endothelial phenotype were investigated in embryonic tissues grafted onto chorioallantoic membrane (CAM) by means of immunocytochemistry and electron microscopy. Single grafts of adrenal gland or cerebellum and double grafts of adrenal gland plus cerebellum were performed, using tissues from chick ...

journal_title：Angiogenesis

authors： Bertossi M,Virgintino D,Coltey P,Errede M,Mancini L,Roncali L

更新日期：1999-01-01 00:00:00

abstract：:The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...

journal_title：Angiogenesis

authors： Liang H,Ge F,Xu Y,Xiao J,Zhou Z,Liu R,Chen C

更新日期：2018-11-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...

journal_title：Angiogenesis

authors： Knowles LM,Malik G,Hood BL,Conrads TP,Pilch J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by interactin...

journal_title：Angiogenesis

authors： Bausch D,Pausch T,Krauss T,Hopt UT,Fernandez-del-Castillo C,Warshaw AL,Thayer SP,Keck T

更新日期：2011-09-01 00:00:00

abstract：:Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether ...

journal_title：Angiogenesis

authors： Zhou J,Zhang H,Wang H,Lutz AM,El Kaffas A,Tian L,Hristov D,Willmann JK

更新日期：2017-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic destructive musculo-skeletal disorder, associated with thickening of the synovial membrane lining the joints, inflammation and hyperproliferation of synovial cells, as well as a pro-inflammatory cytokine cascade, leukocyte infiltration, and tissue damage and bone resorption. An e...

journal_title：Angiogenesis

authors： Paleolog EM,Miotla JM

更新日期：1998-01-01 00:00:00

abstract：:Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

journal_title：Angiogenesis

authors： Pavlakovic H,Havers W,Schweigerer L

更新日期：2001-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the development of CVDs. Piwi-interacting RNAs (piRNAs) are a novel cluster of small non-coding RNAs with strong uracil bias at the 5' end and 2'-O-met...

journal_title：Angiogenesis

authors： Li M,Yang Y,Wang Z,Zong T,Fu X,Aung LHH,Wang K,Wang JX,Yu T

更新日期：2020-10-04 00:00:00

abstract：:Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR...

journal_title：Angiogenesis

authors： Ma T,Patel H,Babapoor-Farrokhran S,Franklin R,Semenza GL,Sodhi A,Montaner S

更新日期：2015-10-01 00:00:00

abstract：:Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype d...

journal_title：Angiogenesis

authors： Kaspi E,Guillet B,Piercecchi-Marti MD,Alfaidy N,Bretelle F,Bertaud-Foucault A,Stalin J,Rambeloson L,Lacroix O,Blot-Chabaud M,Dignat-George F,Bardin N

更新日期：2013-04-01 00:00:00

abstract：:Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...

journal_title：Angiogenesis

authors： van Wijk XM,van Kuppevelt TH

更新日期：2014-07-01 00:00:00

abstract：:Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...

journal_title：Angiogenesis

authors： Mukwaya A,Lennikov A,Xeroudaki M,Mirabelli P,Lachota M,Jensen L,Peebo B,Lagali N

更新日期：2018-05-01 00:00:00

abstract：:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimula...

journal_title：Angiogenesis

authors： Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG

更新日期：1998-01-01 00:00:00

abstract：:Angiogenesis, or new blood vessel formation, is an important process in the pathogenesis of several diseases and thus has been targeted for the prevention and treatment for many disorders. However, the anti-angiogenic agents that are currently in use are mainly synthetic compounds and humanized monoclonal antibodies, ...

journal_title：Angiogenesis

authors： Lu K,Bhat M,Basu S

更新日期：2016-07-01 00:00:00