FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets.

Abstract:

:A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the active ingredient with methanol followed by phosphate buffer pH 6.0. The excipients in the commercial tablet preparation did not interfere with the assay. The specifity, linearity, detection limits, precision and accuracy of the calibration curve, drug extraction, infrared analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with other methods for quantification of ciprofloxacin.

journal_name

Indian J Pharm Sci

authors

Pandey S,Pandey P,Tiwari G,Tiwari R,Rai AK

doi

10.4103/0250-474X.102551

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

86-90

issue

1

eissn

0250-474X

issn

1998-3743

pii

IJPhS-74-86

journal_volume

74

pub_type

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