Abstract:
:A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the active ingredient with methanol followed by phosphate buffer pH 6.0. The excipients in the commercial tablet preparation did not interfere with the assay. The specifity, linearity, detection limits, precision and accuracy of the calibration curve, drug extraction, infrared analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with other methods for quantification of ciprofloxacin.
journal_name
Indian J Pharm Scijournal_title
Indian journal of pharmaceutical sciencesauthors
Pandey S,Pandey P,Tiwari G,Tiwari R,Rai AKdoi
10.4103/0250-474X.102551subject
Has Abstractpub_date
2012-01-01 00:00:00pages
86-90issue
1eissn
0250-474Xissn
1998-3743pii
IJPhS-74-86journal_volume
74pub_type
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