当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Anti-inflammatory treatment in schizophrenia.

Anti-inflammatory treatment in schizophrenia.

Abstract：

:Antipsychotics, which act predominantly as dopamine D2 receptor antagonists, have several shortcomings. The exact pathophysiological mechanism leading to dopaminergic dysfunction in schizophrenia is still unclear, but inflammation has been postulated to be a key player in the pathophysiology of the disorder. A dysfunction in activation of the type 1 immune response seems to be associated with an imbalance in tryptophan/kynurenine metabolism; the degrading enzymes involved in this metabolism are regulated by cytokines. Kynurenic acid (KYNA), an N-methyl-d-aspartate antagonist, was found to be increased in critical regions of the central nervous system (CNS) in schizophrenia, resulting in reduced glutamatergic neurotransmission. The differential activation of microglial cells and astrocytes as functional carriers of the immune system in the CNS may also contribute to this imbalance. The immunological effects of many existing antipsychotics, however, rebalance in part the immune imbalance and overproduction of KYNA. The immunological imbalance results in an inflammatory state combined with increased prostaglandin E(2) production and increased cyclo-oxygenase-2 (COX-2) expression. Growing evidence from clinical studies with COX-2 inhibitors points to favorable effects of anti-inflammatory therapy in schizophrenia, in particular in an early stage of the disorder. Further options for immunomodulating therapies in schizophrenia will be discussed.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Müller N,Myint AM,Krause D,Weidinger E,Schwarz MJ

doi

10.1016/j.pnpbp.2012.11.008

subject

Has Abstract

pub_date

2013-04-05 00:00:00

pages

146-53

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(12)00290-4

journal_volume

42

pub_type

杂志文章,评审

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.

    abstract：:A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is also very high among depressed individuals. Because neuronal nicotinic receptors have been implicated in mood regulation as well as in reinforcing effects of a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.09.010

    authors： Tizabi Y,Getachew B,Rezvani AH,Hauser SR,Overstreet DH

    更新日期：2009-04-30 00:00:00

  • Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.

    abstract：:Magnolia bark and ginger rhizome is a drug pair in many prescriptions for treatment of mental disorders in traditional Chinese medicine (TCM). However, compatibility and synergism mechanism of two herbs on antidepressant actions have not been reported. The aim of this study was to approach the rationale of the drug pa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.03.001

    authors： Yi LT,Xu Q,Li YC,Yang L,Kong LD

    更新日期：2009-06-15 00:00:00

  • Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains.

    abstract：:The use of animal models (particularly rats) in research for developing drugs for central nervous system diseases is well validated. However a range of strains are often utilised in these models. The Lister-Hooded (LH) strain is beginning to be increasingly used in preclinical investigations. Thus, the objective of th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.08.004

    authors： McDermott C,Kelly JP

    更新日期：2008-12-12 00:00:00

  • Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder.

    abstract：BACKGROUND:The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms. METHODS:Mothers and teachers completed a validated DS...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.10.019

    authors： Gadow KD,DeVincent CJ,Siegal VI,Olvet DM,Kibria S,Kirsch SF,Hatchwell E

    更新日期：2013-01-10 00:00:00

  • Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats.

    abstract：:Heroin addicts can benefit from methadone substitution therapy. However, little is known about the significance of pre-exposure to opioids for psychoactive effects of methadone. We modeled some behavioral and neurobiological aspects of the opioid abuse-related phenomena in Sprague-Dawley rats, using morphine (10 mg/kg...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.05.015

    authors： Taracha E,Chrapusta SJ,Lehner M,Skórzewska A,Płaźnik A

    更新日期：2009-08-31 00:00:00

  • Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices.

    abstract：:The neuropeptide substance P (SP) has been suggested to be involved in several physiological and pathological conditions including learning and memory and the processing of pain. This study investigated for the first time acute effects of SP and the neurokinin-1 (NK-1) receptor antagonist L-733060 on long term potenti...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.11.017

    authors： Langosch JM,Kupferschmid S,Heinen M,Walden J,Herpfer I,Fiebich BL,Lieb K

    更新日期：2005-02-01 00:00:00

  • Two types of changes in skin conductance activity after intraventricular administration of 6-hydroxydopamine in rats.

    abstract：:Sixteen male Wistar strain rats were trained to have their skin conductance activity recorded through the soles of their hind limbs, and the effects of the intraventricular administration of 6-OHDA (200 micrograms) on this activity were studied. The intact rats showed skin conductance response and its habituation to r...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90087-9

    authors： Yamamoto K,Kiyosumi H,Yamaguchi K,Moroji T

    更新日期：1985-01-01 00:00:00

  • Birth months and vulnerability to juvenile delinquency.

    abstract：BACKGROUND:Birth months have been shown to affect susceptibility to schizophrenia and other mental disorders, thus this factor could also affect predisposition to delinquency through biological effects on brain development and personality and/or through relative age effects at school. This study aimed to examine the re...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.07.003

    authors： Ohtani T,Sasaki T,Kadomoto I,Kato N,Yoshinaga C

    更新日期：2008-01-01 00:00:00

  • Mitochondrial impairments contribute to spatial learning and memory dysfunction induced by chronic tramadol administration in rat: Protective effect of physical exercise.

    abstract：:Despite the worldwide use of tramadol, few studies have been conducted about its effects on memory and mitochondrial function, and controversial results have been reported. Recently, there has been an increasing interest in physical exercise as a protective approach to neuronal and cognitive impairments. Therefore, th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.07.022

    authors： Mehdizadeh H,Pourahmad J,Taghizadeh G,Vousooghi N,Yoonessi A,Naserzadeh P,Behzadfar L,Rouini MR,Sharifzadeh M

    更新日期：2017-10-03 00:00:00

  • EEG spectral power and mean frequencies in early heroin abstinence.

    abstract：:The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships among electroencephalography (EEG) spectral power and mean frequencies and heroin abuse history. Eyes-closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin ab...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2003.09.022

    authors： Polunina AG,Davydov DM

    更新日期：2004-01-01 00:00:00

  • Consequences of monoamine oxidase inhibition: increased vesicular accumulation of dopamine and norepinephrine and increased metabolism by catechol-O-methyltransferase and phenolsulfotransferase.

    abstract：:1. Male Sprague-Dawley rats were injected with saline, L-Dopa or pargyline. 2. Synaptic vesicles were prepared from whole brain homogenates. Catecholamines and their metabolites in brain tissues and in synaptic vesicles were measured by high performance liquid chromatography with electrochemical detection. 3. L-Dopa a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90147-4

    authors： Buu NT,Lussier C

    更新日期：1989-01-01 00:00:00

  • Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.

    abstract：:Adolescence is a developmental period marked by robust neural alterations and heightened vulnerability to stress, a factor that is highly associated with increased risk for emotional processing deficits, such as anxiety. Stress-induced upregulation of the dynorphin/kappa opioid receptor (DYN/KOP) system is thought to,...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109812

    authors： Varlinskaya EI,Johnson JM,Przybysz KR,Deak T,Diaz MR

    更新日期：2020-03-02 00:00:00

  • Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients.

    abstract：:Several lines of evidence suggest that the human 5-HT(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. A pharmocogenetics study of this receptor may therefore be useful in developing individualized therapy. But few studies about it have been done. In t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2009.02.008

    authors： Wei Z,Wang L,Xuan J,Che R,Du J,Qin S,Xing Y,Gu B,Yang L,Li H,Li J,Feng G,He L,Xing Q

    更新日期：2009-04-30 00:00:00

  • Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.

    abstract：OBJECTIVE:Recently, traditional herbal medicines have been reported to be effective for behavioral and psychological symptoms of dementia (BPSD). This study aims to examine the efficacy of Yi-Gan San (YGS) in the improvement of BPSD and sleep disorders in patients with dementia. METHODS:Five patients (1 male and 4 fem...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.12.027

    authors： Shinno H,Inami Y,Inagaki T,Nakamura Y,Horiguchi J

    更新日期：2008-04-01 00:00:00

  • Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individuals.

    abstract：:The authors sought to determine whether sustained-release (SR) isradipine provided comparable systemic availability to that of immediate-release (IR) isradipine in non-treatment-seeking, cocaine-dependent individuals. This information could be used to design a rational dosage regimen for additional isradipine clinical...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2004.08.014

    authors： Johnson BA,Javors MA,Lam YW,Wells LT,Tiouririne M,Roache JD,Ait-Daoud N,Lawson K

    更新日期：2005-01-01 00:00:00

  • Autoradiography reveals selective changes in serotonin binding in neocortex of patients with temporal lobe epilepsy.

    abstract：:The main goal of the present study was to evaluate binding to serotonin in the neocortex surrounding the epileptic focus of patients with mesial temporal lobe epilepsy (MTLE). Binding to 5-HT, 5-HT(1A), 5-HT(4), 5-HT(7) receptors and serotonin transporter (5-HTT) in T1-T2 gyri of 15 patients with MTLE and their correl...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.04.014

    authors： Rocha L,Lorigados-Pedre L,Orozco-Suárez S,Morales-Chacón L,Alonso-Vanegas M,García-Maeso I,Villeda-Hernández J,Osorio-Rico L,Estupiñán B,Quintana C

    更新日期：2007-08-15 00:00:00

  • Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.

    abstract：:Ca(2+)-dependent activator protein for secretion 2 (CADPS2), a secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF) which have been implicated in psychiatric disorders. Furthermore, the expression of CADPS2deltaExon3, a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.05.004

    authors： Hattori K,Tanaka H,Wakabayashi C,Yamamoto N,Uchiyama H,Teraishi T,Hori H,Arima K,Kunugi H

    更新日期：2011-08-15 00:00:00

  • Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioning.

    abstract：:Previous investigations have revealed sex-specific differences in brain morphometry. The effect of sex on cortical thickness may be influencing cognitive differences between sexes. With this exploratory study, we aimed to investigate the effect of sex in MRI-based cerebral cortex morphometry in healthy young volunteer...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.01.005

    authors： Crespo-Facorro B,Roiz-Santiáñez R,Pérez-Iglesias R,Mata I,Rodríguez-Sánchez JM,Tordesillas-Gutiérrez D,Ortíz-García de la Foz V,Tabarés-Seisdedos R,Sánchez E,Andreasen N,Magnotta V,Vázquez-Barquero JL

    更新日期：2011-03-30 00:00:00

  • Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia.

    abstract：:CYP1A2 is an important inducible enzyme involved in the metabolism of antipsychotics. This study examined two functional polymorphisms in the gene as potential markers in predicting prolongation of QTc interval in patients treated with antipsychotics. QT intervals were measured by 12-lead electrocardiography (ECG) for...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.05.013

    authors： Tay JK,Tan CH,Chong SA,Tan EC

    更新日期：2007-08-15 00:00:00

  • Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.

    abstract：:In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. A d...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(01)00192-0

    authors： Allison AC,Cacabelos R,Lombardi VR,Alvarez XA,Vigo C

    更新日期：2001-10-01 00:00:00

  • No association between the neuronal pentraxin II gene polymorphism and autism.

    abstract：:Autism (MIM 209850) is a neurodevelopmental disorder characterized by difficulties with verbal and non-verbal communication, impairments in reciprocal social interactions, and displays of stereotypic behaviors, interests and activities. Twin and family studies have indicated a robust role of genetic factors in the dev...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.02.016

    authors： Marui T,Koishi S,Funatogawa I,Yamamoto K,Matsumoto H,Hashimoto O,Ishijima M,Nanba E,Nishida H,Sugiyama T,Kasai K,Watanabe K,Kano Y,Kato N,Sasaki T

    更新日期：2007-05-09 00:00:00

  • A nicotinic receptor antagonist enhances the hypothermic response to a muscarinic agonist.

    abstract：:1. Chronic treatment with amitriptyline produces supersensitivity to the hypothermic effects of the muscarinic agonist oxotremorine. 2. Chronic treatment with amitriptyline also produces supersensitivity to the hypothermic effects of nicotine. 3. Oxotremorine and other naturally occurring muscarinic agonists are also ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90029-z

    authors： Dilsaver SC,Majchrzak MJ,Snider RM,Davidson RK

    更新日期：1991-01-01 00:00:00

  • No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder.

    abstract：:Several lines of evidence suggest that genetic factors might contribute to susceptibility to panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.04.018

    authors： Shimizu E,Hashimoto K,Koizumi H,Kobayashi K,Itoh K,Mitsumori M,Ohgake S,Okamura N,Koike K,Matsuzawa D,Zhang L,Kumakiri C,Nakazato M,Komatsu N,Iyo M

    更新日期：2005-06-01 00:00:00

  • An MRI study of the basal ganglia in autism.

    abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00020-2

    authors： Sears LL,Vest C,Mohamed S,Bailey J,Ranson BJ,Piven J

    更新日期：1999-05-01 00:00:00

  • Event-related brain potentials in depressed patients treated with electroconvulsive therapy.

    abstract：:1. As impairment of attention has long been recognized as a clinical feature of depression, we undertook to evaluate in depressed subjects and controls a feature of the event-related brain potentials (ERP) the N100 wave which has been linked to attentional processes. 2. This study involved collection of EEG data in an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90056-0

    authors： Coffman JA,Torello MW,Lewis CE,Fortin LD,Martin DJ

    更新日期：1989-01-01 00:00:00

  • Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.

    abstract：:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly mea...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.09.013

    authors： Rothermundt M,Ohrmann P,Abel S,Siegmund A,Pedersen A,Ponath G,Suslow T,Peters M,Kaestner F,Heindel W,Arolt V,Pfleiderer B

    更新日期：2007-03-30 00:00:00

  • A monoamine oxidase B gene variant and short-term antidepressant treatment response.

    abstract：:Genetic differences among patients suffering from Major Depression are likely to contribute to interindividual differences in medication treatment response. Thus, the identification of gene variants affecting drug response is needed in order to be able to predict response to psychopharmacological drugs. This study ana...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2007.05.015

    authors： Tadić A,Rujescu D,Müller MJ,Kohnen R,Stassen HH,Dahmen N,Szegedi A

    更新日期：2007-10-01 00:00:00

  • Stereopsychopharmacology: past, present and future.

    abstract：:Stereoisomers have been used for more than a century to study the role of three-dimensional (spatial) features in biological processes. Configuration and conformation are spatial features of primary interest for effects of drugs. The role of configuration has been studied mainly by comparing effects of optical isomers...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Smith DF

    更新日期：1984-01-01 00:00:00

  • Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice.

    abstract：:The rate of hippocampal neurogenesis declines with aging. This is partly explained by decreased neural responsiveness to various cues stimulating metabolism. AMP-activated protein kinase (AMPK), a pivotal enzyme regulating energy homeostasis in response to metabolic demands, showed the diminished sensitivity in periph...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2016.06.011

    authors： Jang S,Kim H,Jeong J,Lee SK,Kim EW,Park M,Kim CH,Lee JE,Namkoong K,Kim E

    更新日期：2016-11-03 00:00:00

  • Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine.

    abstract：:The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical respons...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2016.12.003

    authors： Gassó P,Rodríguez N,Blázquez A,Monteagudo A,Boloc D,Plana MT,Lafuente A,Lázaro L,Arnaiz JA,Mas S

    更新日期：2017-04-03 00:00:00