Abstract:
:Cardiac vagal tone (CVT), a key determinant of resting heart rate (HR), is progressively withdrawn with incremental exercise and nearly abolished at maximal effort. While maximal HR decreases with age, there remains a large interindividual variability of results for any given age. In the present study, we hypothesized that CVT does not contribute to age-independent maximal HR. Data were obtained from 1 000 (39±14 years old) healthy subjects (719 men) who were not taking medications affecting CVT or maximal HR performed a clinically normal and truly maximal cardiopulmonary exercise testing. CVT was estimated using the cardiac vagal index (CVI), a dimensionless ratio obtained by dividing 2 cardiac cycle durations--end of exercise and pre-exercise--, reflecting HR increases during a 4-s unloaded cycling test (a vagally-mediated response). Maximal HR was expressed as % of that predicted by age (208-0.7 × age (years)). Linear regression analyses identified that CVI can explain only 1% of the % age-predicted maximal HR variability with a high standard error of estimate (~6.3%), indicating the absence of a true physiological cause-effect relationship. In conclusion, the influence of CVI on % of age-predicted maximal HR is null in healthy subjects, suggesting distinct physiological mechanisms and potential clinical complementary role for these exercise-related variables.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Duarte CV,Araujo CGdoi
10.1055/s-0032-1323818subject
Has Abstractpub_date
2013-06-01 00:00:00pages
502-6issue
6eissn
0172-4622issn
1439-3964journal_volume
34pub_type
杂志文章abstract::Long-term side effects of high doses of anabolic androgenic steroids self-administration were evaluated in this study. Twenty male bodybuilders, voluntarily starting steroid self-administration, were followed every 6 months over 2 years. Physical examination, haematological, metabolic and endocrine variables, semen an...
journal_title:International journal of sports medicine
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journal_title:International journal of sports medicine
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journal_title:International journal of sports medicine
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of sports medicine
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journal_title:International journal of sports medicine
pub_type: 临床试验,杂志文章
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journal_title:International journal of sports medicine
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