fMRI evidence for dorsal stream processing abnormality in adults born preterm.

Abstract:

:We investigated the consequences of premature birth on the functional neuroanatomy of the dorsal stream of visual processing. fMRI was recorded while sixteen healthy participants, 8 (two men) adults (19 years 6 months old, SD 10 months) born premature (mean gestational age 30 weeks), referred to as Premas, and 8 (two men) matched controls (20 years 1 month old, SD 13 months), performed a 1-back memory task of Object or Grip information using a hand grasping a drinking vessel as stimulus. While history of prematurity did not significantly affect task performance, Group by Task analysis of variance in regions of interest spanning the occipital, temporal and parietal lobes revealed main effects of Task and interactions between the two factors. Object processing activated the left inferior occipital cortex and bilateral ventral temporal regions, belonging to the ventral stream, with no effect of Group. Grip processing across groups activated the early visual cortex and the left supramarginal gyrus belonging to the dorsal stream. Group effect on the brain activity during Grip suggested that Controls represented the actions' goal while Premas relied more on low-level visual information. This shift from higher- to lower-order visual processing between Controls and Premas may reflect a more general trend, in which Premas inadequately recruit higher-order visual functions for dorsal stream task performance, and rely more on lower-level functions.

journal_name

Brain Cogn

journal_title

Brain and cognition

authors

Chaminade T,Leutcher RH,Millet V,Deruelle C

doi

10.1016/j.bandc.2012.10.006

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

67-72

issue

1

eissn

0278-2626

issn

1090-2147

pii

S0278-2626(12)00142-X

journal_volume

81

pub_type

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