Abstract:
PURPOSE OF REVIEW:Nod-like receptors (NLRs) are intracellular innate immune sensors of microbes and danger signals that control multiple aspects of inflammatory responses. We review the evidence that highlights the critical importance of NLRs in the host response to intestinal pathogens. Moreover, we discuss the potential roles played by NLRs in the dynamic control of the intestinal microbiota and how commensal microorganisms may affect host susceptibility to enteric bacterial pathogens through interactions with NLRs as well as with invading pathogens. RECENT FINDINGS:Recent studies targeting the intestinal microbiota in the context of NLR deficiencies suggest inherent alterations in bacterial density or abundance may underlie the development of inflammatory diseases. As commensal microorganisms may also affect host susceptibility to enteric bacterial pathogens, NLRs might promote intestinal innate immune defense through mechanisms more complex than previously anticipated. SUMMARY:The inclusion of the intestinal microbiota as a critical parameter in innate immunity represents an exciting new dimension for understanding NLR functioning and the clinical implications for human health.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Robertson SJ,Girardin SEdoi
10.1097/MOG.0b013e32835a68easubject
Has Abstractpub_date
2013-01-01 00:00:00pages
15-22issue
1eissn
0267-1379issn
1531-7056journal_volume
29pub_type
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32831ef1cd
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The most relevant studies concerning the diagnosis of esophageal varices, primary and secondary prophylaxis and treatment of variceal bleeding published in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to studies on the noninvasive or minimally invasive ...
journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e3281299011
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abstract:PURPOSE OF REVIEW:The aim of this article is to highlight literature published during the last year in the context of previous knowledge. RECENT FINDINGS:A number of novel techniques - high-resolution manometry, esophageal electrical impedance and intra-luminal ultrasound imaging - have improved our understanding of e...
journal_title:Current opinion in gastroenterology
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更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Conflicting reports in the literature have been misinterpreted by clinicians, who conclude that nutritional therapy for the hospitalized patient is of marginal value. The true benefit of such therapy is derived from the provision of early enteral nutrition. This article describes the physiologic respo...
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更新日期:2018-09-01 00:00:00
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journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e328330da7b
更新日期:2009-11-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Current opinion in gastroenterology
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doi:10.1097/00001574-200309000-00005
更新日期:2003-09-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Food addiction has been implicated as a putative causal factor in chronic overeating, binge eating, and obesity. The concept of food addiction has been controversial historically due to definitional and conceptual difficulties and to a lack of rigorous scientific data. RECENT FINDINGS:Support for the...
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doi:10.1097/MOG.0b013e328336528d
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To consider observations suggesting that the bacterial protein flagellin, the primary structural component of flagella, plays a major role in mediating gut inflammation associated with infection by enteric pathogens and in inflammatory bowel disease. RECENT FINDINGS:Biochemical dissection of an in-vi...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000194791.59337.28
更新日期:2006-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000315
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review new advances in gastric interventional endoscopy. RECENT FINDINGS:Implementation of gastric endoscopy as a therapeutic option in obesity, gastric cancer, and gastroparesis. SUMMARY:Less invasive new gastric endoscopic procedures can potentially replace currently offered laparoscopic approa...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
abstract::The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199907000-00013
更新日期:1999-07-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000202
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Endoscopic ampullectomy has proven its safety and efficacy in multiple studies, making it the favorable option for the management of endoscopic ampullectomy. In this review, we plan to review the basic steps every endoscopist should be familiar with before undertaking endoscopic ampullectomy. RECENT ...
journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0000000000000657
更新日期:2020-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Morbid obesity is associated with a high prevalence of psychopathological conditions that might have an impact on postsurgery outcomes. This review summarizes recent data about psychological disorders in obese patients before and after bariatric surgery as well as the assessment and impact of these fa...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3283422482
更新日期:2011-03-01 00:00:00
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journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e32835a670e
更新日期:2013-01-01 00:00:00
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doi:10.1097/MOG.0b013e32831b4455
更新日期:2009-01-01 00:00:00
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更新日期:2013-03-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
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更新日期:2019-05-01 00:00:00