Abstract:
:Obesity-related disorders derive from a combination of genetic susceptibility and environmental factors. Recent evidence supports the role of gut microbiota in the pathogenesis of obesity, type 2 diabetes mellitus, and insulin resistance by increasing energy harvest from diet and by inducing chronic, low-grade inflammation. Several studies describe characteristic differences between composition and activity of gut microbiota of lean individuals and those with obesity. Despite this evidence, some pathophysiological mechanisms remain to be clarified. This article discusses mechanisms connecting gut microbiota to obesity and fat storage and the potential therapeutic role of probiotics and prebiotics.
journal_name
Gastroenterol Clin North Amjournal_title
Gastroenterology clinics of North Americaauthors
Molinaro F,Paschetta E,Cassader M,Gambino R,Musso Gdoi
10.1016/j.gtc.2012.08.009subject
Has Abstractpub_date
2012-12-01 00:00:00pages
843-54issue
4eissn
0889-8553issn
1558-1942pii
S0889-8553(12)00103-3journal_volume
41pub_type
杂志文章,评审abstract::In the treatment of arthritis, NSAIDs are some of the most commonly used drugs, although the prescription of such drugs has been questioned due to their inherent risks for gastrointestinal compromise, platelet effects, and the potential for renal toxicity with long-term use. With the availability of celecoxib and rofe...
journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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journal_title:Gastroenterology clinics of North America
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