Four disruptive strategies for removing drug discovery bottlenecks.

Abstract:

:Drug discovery is shifting focus from industry to outside partners and, in the process, creating new bottlenecks. Technologies like high throughput screening (HTS) have moved to a larger number of academic and institutional laboratories in the USA, with little coordination or consideration of the outputs and creating a translational gap. Although there have been collaborative public-private partnerships in Europe to share pharmaceutical data, the USA has seemingly lagged behind and this may hold it back. Sharing precompetitive data and models may accelerate discovery across the board, while finding the best collaborators, mining social media and mobile approaches to open drug discovery should be evaluated in our efforts to remove drug discovery bottlenecks. We describe four strategies to rectify the current unsustainable situation.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Ekins S,Waller CL,Bradley MP,Clark AM,Williams AJ

doi

10.1016/j.drudis.2012.10.007

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

265-71

issue

5-6

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(12)00360-1

journal_volume

18

pub_type

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