Physiological challenges of bone repair.

Abstract:

:Bone healing after fracture occurs in a well-organized manner and involves a multitude of cell types, inflammatory cytokines, growth factors, prostaglandins, and certain vitamins. Some of the means by which alterations in these essential components affect bone repair are understood, whereas others still need to be delineated. Based on clinical experience and basic science research, certain clinical conditions have become associated with delays in bone repair after fracture. These conditions include chronic inflammation, diabetes, hypovitaminosis, aging, and polytrauma. This brief report reviews some of the ways by which these conditions have been shown to negatively influence bone repair.

journal_name

J Orthop Trauma

authors

Borrelli J Jr,Pape C,Hak D,Hsu J,Lin S,Giannoudis P,Lane J

doi

10.1097/BOT.0b013e318274da8b

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

708-11

issue

12

eissn

0890-5339

issn

1531-2291

journal_volume

26

pub_type

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