Cyclosporin-responsive enteropathy and protracted diarrhea.

Abstract:

:We describe a child born to unrelated parents who developed severe protracted secretory type diarrhea associated with subtotal villus atrophy and intestinal inflammation at the age of 19 months. No infectious, metabolic, or anatomical basis for this condition was identified and the child required total parenteral nutrition for a period of 18 months despite trials of special enteral formulas, steroids, and anti-inflammatory agents. This refractory "enteropathy" responded dramatically to the introduction of cyclosporin, with cessation of the secretory diarrhea, recovery from the enteropathy, and cessation of parenteral nutrition. The symptoms relapsed when cyclosporin was briefly discontinued and improved following reintroduction of this drug. This experience suggests a role for immune factors in the pathogenesis of the enteropathy in this case and that a trial of cyclosporin is worthy of consideration in similar cases.

authors

Coulthard M,Searle J,Patrick M,Ravenscroft P,Cleghorn G,Shepherd R

doi

10.1097/00005176-199002000-00021

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

257-61

issue

2

eissn

0277-2116

issn

1536-4801

journal_volume

10

pub_type

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