P2Y purinoceptors as potential emerging therapeutical target in vascular disease.

abstract：:The acidic amino acid L-glutamate acts as both a primary excitatory neurotransmitter and a potential neurotoxin within the mammalian central nervous system. Functionally juxtaposed between these neurophysiological and pathological actions are an assorted group of integral membrane transporter proteins that rapidly and...

journal_title：Current pharmaceutical design

authors： Bridges RJ,Kavanaugh MP,Chamberlin AR

更新日期：1999-05-01 00:00:00

abstract：:Circumstantial evidence has been provided of a role of the plasminogen/plasmin system in a variety of biological phenomena, including thrombolysis, vascular stenosis, reproduction, embryogenesis, cell invasion, angiogenesis, brain function and chronic lung or kidney inflammatory disorders. Inhibition of the system occ...

journal_title：Current pharmaceutical design

authors： Matsuno H

更新日期：2006-01-01 00:00:00

abstract：:Iron oxide (Fe₃O₄) nanoparticles (IONPs) have received much attention for their utility in biomedical applications such as magnetic resonance imaging, drug delivery and hyperthermia. Recent studies reported that IONPs induced cytotoxicity in mammalian cells. However, little is known about the genotoxicity of IONPs fol...

journal_title：Current pharmaceutical design

authors： Ahamed M,Alhadlaq HA,Alam J,Khan MA,Ali D,Alarafi S

更新日期：2013-01-01 00:00:00

abstract：:Interest in opioid drugs like morphine, as the oldest and most potent pain-killing agents known, has been maintained through the years. One of the most frequent chronic pain sensations people experience is associated with pathological conditions of the musculoskeletal system. Chronic musculoskeletal pain is a major he...

journal_title：Current pharmaceutical design

authors： Spetea M

更新日期：2013-01-01 00:00:00

abstract：:In the present review, associations between traditional vascular risk factors (VRFs) and carotid intimamedial thickness progression (C-IMTp) as well as the effects of therapies for VRFs control on C-IMTp were appraised to infer causality between each VRF and C-IMTp. Cohort studies indicate that smoking, binge drinking...

journal_title：Current pharmaceutical design

authors： Frigerio B,Werba JP,Amato M,Ravani A,Sansaro D,Coggi D,Vigo L,Tremoli E,Baldassarre D

更新日期：2020-01-01 00:00:00

abstract：:This review presents a comprehensive attempt to conclude and discuss various glucose biosensors based on core@shell magnetic nanomaterials. Owing to good biocompatibility and stability, the core@shell magnetic nanomaterials have found widespread applications in many fields and draw extensive attention. Most magnetic n...

journal_title：Current pharmaceutical design

authors： Liu L,Lv H,Teng Z,Wang C,Wang G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity. METHODS:This arti...

journal_title：Current pharmaceutical design

authors： Bruno RM,Ghiadoni L

更新日期：2018-01-01 00:00:00

abstract：:Humans have always lived with tubercle bacilli. Host susceptibility both inherited and acquired determines whether an individual infected with Mycobacterium tuberculosis will eventually fall ill and develop tuberculosis (TB). After infection with M. tuberculosis, a latent TB infection may ensue reflected by immune r...

journal_title：Current pharmaceutical design

authors： van Altena R,Duggirala S,Gröschel MI,van der Werf TS

更新日期：2011-01-01 00:00:00

abstract：:Infections are the most common inflammatory triggers and acute and chronic infections have been associated with the development and progression of atherosclerotic disease raising interest in the infectious hypothesis of atherosclerosis. Pathogens have been identified in atherosclerotic plaques and large epidemiologica...

journal_title：Current pharmaceutical design

authors： Charakida M,Tousoulis D

更新日期：2013-01-01 00:00:00

abstract：:Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are...

journal_title：Current pharmaceutical design

authors： Florentin M,Liberopoulos EN,Mikhailidis DP,Elisaf MS

更新日期：2008-01-01 00:00:00

abstract：:LIM (Lin-11, Isl-1, Mec-3), RING (Really interesting new gene), PHD (Plant homology domain) and MYND (myeloid, Nervy, DEAF-1) domains are all zinc-binding domains that ligate two zinc ions. Unlike the better known classical zinc fingers, these domains do not bind DNA, but instead mediate interactions with other protei...

journal_title：Current pharmaceutical design

authors： Matthews JM,Bhati M,Lehtomaki E,Mansfield RE,Cubeddu L,Mackay JP

更新日期：2009-01-01 00:00:00

abstract：:Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated tryptase as a mediator in the pathology of numerous allergic and inflammatory conditions including rhinitis, conjunctivitis, and most notably asthma. A growing...

journal_title：Current pharmaceutical design

authors： Rice KD,Tanaka RD,Katz BA,Numerof RP,Moore WR

更新日期：1998-10-01 00:00:00

abstract：:Pituitary adenylyl cyclase activating polypeptide (PACAP) is a neuropeptide with great neuroprotective effects and remarkable therapeutic potential. PACAP activates several cellular pathways to exert its protective effects. Emerging evidence shows that PACAP can modify the levels and activity of cell cycle components ...

journal_title：Current pharmaceutical design

authors： Polanco MJ,Pennuto M

更新日期：2018-01-01 00:00:00

abstract：:Guidelines for the treatment of hypertension allow a wide range of choices to the physicians; however some differences are present about the preferred drugs to start treatment. The most important aim remains an adequate decrease of blood pressure, something not perfectly obtained in the general population, but some cl...

journal_title：Current pharmaceutical design

authors： Pende A,Dallegri F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUNDS:Targeted therapy is the foundation of personalized medicine in cancer, which is often understood as the right patient using the right drug. Thinking from the viewpoint of determinants during personalized drug treatment, the genetics, epigenetics and metagenomics would provide individual-specific biological ...

journal_title：Current pharmaceutical design

authors： Wang L,Yu X,Zhang C,Zeng T

更新日期：2018-01-01 00:00:00

abstract：:Carvedilol is a nonselective β-blocker with α1-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit in heart failure. However, less research has been done in the area of animal models of viral myocarditis. T...

journal_title：Current pharmaceutical design

authors： Yue-Chun L,Li-Sha G,Xue-Qiang G,Jia-Feng L

更新日期：2012-01-01 00:00:00

abstract：:Philosophers have been trying to solve the mind-body problem for hundreds of years. Consciousness is the core of this problem: How do subjective conscious sensations, perceptions, feelings, and thoughts arise out of objective physical brain activities? How is this subjective conscious world in causal interaction with ...

journal_title：Current pharmaceutical design

authors： Långsjo JW,Revonsuo A,Scheinin H

更新日期：2014-01-01 00:00:00

abstract：:The treatment of skin wounds represents an important research area due to the important physiological and aesthetic role of this tissue. During the last years, nanoparticles have emerged as important platforms to treat skin wounds. Silver, gold, and copper nanoparticles, as well as titanium and zinc oxide nanoparticle...

journal_title：Current pharmaceutical design

authors： Oyarzun-Ampuero F,Vidal A,Concha M,Morales J,Orellana S,Moreno-Villoslada I

更新日期：2015-01-01 00:00:00

abstract：:Several diseases of the heart have been linked to an insufficient ability to generate enough energy (ATP) to sustain proper heart function. Hyperpolarized magnetic resonance (MR) is a novel technique that can visualize and quantify myocardial energy metabolism. Hyperpolarization enhances the MR signal from a biologica...

journal_title：Current pharmaceutical design

authors： Lauritzen MH,Sogaard LV,Madsen PL,Ardenkjaer-Larsen JH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The drug delivery of macromolecules such as proteins and peptides has become an important area of research and represents the fastest expanding share of the market for human medicines. The most common method for delivering macromolecules is parenterally. However parenteral administration of some therapeutic ...

journal_title：Current pharmaceutical design

authors： Shadab M,Haque S,Sheshala R,Meng LW,Meka VS,Ali J

更新日期：2017-01-01 00:00:00

abstract：:Catheter ablation for rhythm control in atrial fibrillation has been recognized as an established treatment. Patients with atrial fibrillation suffer from an increased risk of thromboembolic events. Long-term stroke risk and mortality have been shown to be reduced after catheter ablation, still the procedure per se is...

journal_title：Current pharmaceutical design

authors： Vrachatis DA,Giannopoulos G,Kossyvakis C,Panagopoulou V,Vavuranakis M,Papaioannou TG,Pagoni S,Pyrgakis VN,Cleman MW,Deftereos SG

更新日期：2017-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis are the two principal forms of inflammatory bowel disease (IBD). The root causes of these chronic and acute immunological disorders are unclear, but intestinal microorganisms are known to play a key role in the initiation and maintenance of disease. However, at present, there is ...

journal_title：Current pharmaceutical design

authors： Macfarlane GT,Blackett KL,Nakayama T,Steed H,Macfarlane S

更新日期：2009-01-01 00:00:00

abstract：:There is growing evidence for the involvement of glutamatergic abnormalities in schizophrenia. Uncompetitive NMDA receptor (NMDAR) antagonists induce effects closely resembling both the positive and negative symptoms of schizophrenia; candidate risk genes for schizophrenia converge on the NMDAR expressing synapse; and...

journal_title：Current pharmaceutical design

authors： Stone JM

更新日期：2009-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) has been widely used as a target for novel anticancer agents, such as blocking antibodies and small molecular weight tyrosine kinase compounds. In spite of recent advances in cancer cell biology, leading to the introduction of clinically active new drugs, such as cetuximab, ...

journal_title：Current pharmaceutical design

authors： Bianco R,Damiano V,Gelardi T,Daniele G,Ciardiello F,Tortora G

更新日期：2007-01-01 00:00:00

abstract：:We have gained considerable insight and understanding about the etiology, embryogenesis of the myocardium, genetic background, diagnosis and outcome of left ventricular non-compaction (LVNC) over the last 2 decades. LVNC has a distinct morphological appearance with a thickened, two-layered myocardium consisting of an ...

journal_title：Current pharmaceutical design

authors： Ganame J

更新日期：2015-01-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:In recent years, new strategies in cancer therapy have been developed targeting key signaling molecules in the receptor tyrosine kinase signal transduction pathway. In contrast, most therapeutical concepts to manipulate G protein-coupled receptors (GPCR)-mediated disorders are still limited to the use of receptor-spec...

journal_title：Current pharmaceutical design

authors： Liebmann C

更新日期：2004-01-01 00:00:00

abstract：:The hypothesis that the interaction of agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4R) modulates feeding behavior in humans has stimulated the synthesis of conformationally constrained peptides, peptoids and small molecules in efforts to identify novel compounds that can potentially be used in the...

journal_title：Current pharmaceutical design

authors： Wang X,Richards NG

更新日期：2005-01-01 00:00:00

abstract：:Many plant species and tissues have been investigated as production and delivery vehicles for recombinant pharmaceutical proteins. Examples include cultured cells, whole aquatic plants and transgenic plants expressing recombinant proteins in their leaves, seeds, fruits or tubers/roots. Each platform has unique propert...

journal_title：Current pharmaceutical design

authors： Hofbauer A,Stoger E

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The 3' repair exonuclease 1 (TREX1) gene is the major DNA-specific 3'-5 'exonuclease of mammalian cells which reduces single- and double-stranded DNA (ssDNA and dsDNA) to prevent undue immune activation mediated by the nucleic acid. TREX1 is also a crucial suppressor of selfrecognition that pr...

journal_title：Current pharmaceutical design

authors： Tao SS,Wu GC,Zhang Q,Zhang TP,Leng RX,Pan HF,Ye DQ

更新日期：2019-01-01 00:00:00