A repeated dose comparison of three benzodiazepine derivative (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night-time medication.

Abstract:

:Repeated doses of 5 mg nitrazepam, 15 mg flurazepam, and 1 mg flunitrazepam improved subjective assessments of the ease of getting to sleep and the perceived quality of induced sleep in a population of 30 healthy volunteers. The subjective reports of improved sleep inducement were related to a perceived difficulty in awakening from sleep the morning following medication. This subjectively reported "hangover" is also shown in the impairment of mental arithmetic abilities as measured on the serial subtraction of sevens technique. However, complex psychomotor performance is unaffected by repeated administration of these three benzodiazepine derivatives, although these later results are somewhat equivocal. Evidence of a "rebound phenomenon" following 4 nights' withdrawal of active medication is shown in both subjective and objective measures of sleep and early morning behaviour.

journal_name

Acta Psychiatr Scand

authors

Hindmarch I

doi

10.1111/j.1600-0447.1977.tb06678.x

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

373-81

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

56

pub_type

临床试验,杂志文章
  • Priapism and neuroleptics: a case report.

    abstract::We present a case of priapism caused by the alpha adrenoreceptor blocking action of a butyrophenone. The problem was solved surgically performing a cavernousspongiosum fistula. ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05086.x

    authors: Morera A,Estrada AG,Valenciano R

    更新日期:1988-01-01 00:00:00

  • How many well vs. unwell days can you expect over 10 years, once you become depressed?

    abstract:OBJECTIVE:Prognostic studies of major depression have mainly focused on episode remission and relapse, and only a limited number of studies have examined long-term course of depressive symptomatology at threshold and subthreshold levels. METHOD:The Group for Longitudinal Affective Disorders Study has conducted prospec...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2008.01288.x

    authors: Furukawa TA,Yoshimura R,Harai H,Imaizumi T,Takeuchi H,Kitamura T,Takahashi K

    更新日期:2009-04-01 00:00:00

  • Outcome of systemic and analytic group psychotherapy for adult women with history of intrafamilial childhood sexual abuse: a randomized controlled study.

    abstract:OBJECTIVE:Research suggests that group psychotherapy for adults with a history of child sexual abuse (CSA) is generally beneficial. Only few studies have included random assignment. This study compared the effects of analytic (A) and systemic group psychotherapy (S) on CSA. METHOD:One hundred and fifty-one women with ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.2006.00977.x

    authors: Lau M,Kristensen E

    更新日期:2007-08-01 00:00:00

  • Are there subtypes of bipolar depression?

    abstract:OBJECTIVE:To investigate for subtypes of bipolar depression using latent class analysis (LCA). METHOD:Participants were recruited through a bipolar disorder (BD) clinic. LCA was undertaken using: (i) symptoms reported on the SCID-IV for the most severe lifetime depressive episode; (ii) lifetime illness features such a...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12615

    authors: Perich T,Hadzi-Pavlovic D,Frankland A,Breakspear M,Loo C,Roberts G,Holmes-Preston E,Mitchell PB

    更新日期:2016-09-01 00:00:00

  • Diagnosis change, lithium use and admissions for mania in Edinburgh.

    abstract::Admissions for mania have risen significantly in Edinburgh since 1970. Differencing was used to remove time trends; this showed that the rise was not accounted for by diagnosis change (from schizophrenia or personality disorder) or by lithium prescription. The contribution of non-specific factors such as admission pol...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb03002.x

    authors: Mander AJ

    更新日期:1989-11-01 00:00:00

  • Successful use of a selective serotonin reuptake inhibitor in a patient with multiple chemical sensitivities.

    abstract::A 53-year-old man with multiple chemical sensitivities (MCS) received the selective serotonin reuptake inhibitor (SSRI) citalopram for treatment of depression. The treatment was successful and, in parallel to the remission of the depressive symptoms, all MCS symptoms vanished. This suggests that a subgroup of MCS pati...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1997.tb09910.x

    authors: Andiné P,Rönnbäck L,Järvholm B

    更新日期:1997-07-01 00:00:00

  • Polyneuropathy caused by chlorprothixene.

    abstract::Seven chronic psychiatric patients developed signs of polyneuropathy mainly in the lower limbs after receiving chlorprothixene (500-1800 mg/d) from 3 to more than 24 months. The most prominent electroneuromyographic findings were decreased or not measurable motor conduction velocities of the peroneal nerves. Electromy...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb08604.x

    authors: Luisto M

    更新日期:1992-03-01 00:00:00

  • Elective mutism.

    abstract::Eleven children who had received a diagnosis of elective mutism upon admission to the children's psychiatric clinic, were followed up 8--18 years later. The average age upon admission was 9 1/2 years, and at the time of follow-up, 23 years. Nine of the children came from homes with a strong familial shyness and reserv...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1979.tb06962.x

    authors: Wergeland H

    更新日期:1979-02-01 00:00:00

  • Group cognitive behavioural therapy for obsessive-compulsive disorder: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Behaviour therapy with exposure and response prevention (ERP) or cognitive behavioural therapy (CBT) including ERP are considered the psychological treatments of choice for obsessive-compulsive disorder (OCD), but group CBT/ERP has received relatively little research attention in the treatment of OCD. The aim...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1600-0447.2008.01270.x

    authors: Jónsson H,Hougaard E

    更新日期:2009-02-01 00:00:00

  • Anxiety and EEG alpha activity in neurotic patients.

    abstract::The literature is reviewed on EEG alpha activity in different psychological states, i.e., morbid anxiety, attention and mental relaxation. In the present study, 20 male neurotic inpatients suffering from chronic moderate anxiety were assessed with respect to anxiety level and EEG alpha activity (frequency and per cent...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1975.tb00028.x

    authors: Siciliani O,Schiavon M,Tansella M

    更新日期:1975-08-01 00:00:00

  • Suicidal behaviour in major depressive illness.

    abstract::We investigated past suicidal behaviour and family history of suicide in 713 inpatients with major depressive illness. A familial history of suicide (mainly violent) significantly increased the frequency of violent suicidal behaviour in depressive women; bipolar patients being more affected than unipolars. In depresse...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1985.tb02600.x

    authors: Linkowski P,de Maertelaer V,Mendlewicz J

    更新日期:1985-09-01 00:00:00

  • Aspects of tempo and perception of music in mania.

    abstract::Ten patients with manic psychosis were compared with 20 normal subjects with respect to their ratings of emotional meaning in music. As stimulus two pieces of music for a small symphony orchestra were used. These were structurally identical but performed at two different tempos: slow and fast. The change in tempo was ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1982.tb00825.x

    authors: Nielzén S,Cesarec Z

    更新日期:1982-02-01 00:00:00

  • Patterns of overt sexual interaction among acute psychiatric inpatients.

    abstract::An indepth study was carried out over 1 year on all instances of overt heterosexual interactions among acute psychiatric patients on mixed-sex intensive treatment units. Sixteen of the 1060 patients treated on the units were involved in nine instances of overt heterosexual interactions. Analysis of the interactions sh...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1981.tb00804.x

    authors: Modestin J

    更新日期:1981-11-01 00:00:00

  • Actigraphic patterns, impulsivity and mood instability in bipolar disorder, borderline personality disorder and healthy controls.

    abstract:OBJECTIVES:To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder (BPD) and healthy controls (HC). METHODS:Eighty-seven participants (31 BD, 21 BPD and 35 HC) underwent actigraph...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.13148

    authors: McGowan NM,Goodwin GM,Bilderbeck AC,Saunders KEA

    更新日期:2020-04-01 00:00:00

  • The clinical genetics of Pick's disease.

    abstract::The families of 11 probands with Pick's disease as determined by histopathological examination, were investigated by interview and acquisition of medical records. The estimated morbid risk was 0.25 +/- 0.08 for parents and 0.07 +/- 0.07 for siblings or probands. Further analyses are presented that seek associations be...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1978.tb06886.x

    authors: Heston LL

    更新日期:1978-03-01 00:00:00

  • Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study.

    abstract:OBJECTIVE:To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD. METHOD:The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline,...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12739

    authors: Mesman E,Nolen WA,Keijsers L,Hillegers MHJ

    更新日期:2017-08-01 00:00:00

  • Agreement in psychiatric assessment.

    abstract::In 103 schizophrenic patients we investigated the extent of practice needed in the use of the Brief Psychiatric Rating Scale (BPRS) to enable its reliability to be assessed. The agreement level of the 7 raters was analysed. Generally, the lowest mean agreement found was for the negative symptoms of the BPRS schizophre...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03343.x

    authors: Andersen J,Kørner A,Larsen JK,Schultz V,Nielsen BM,Behnke K,Munk-Andersen E,Bjørum N

    更新日期:1993-02-01 00:00:00

  • Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients.

    abstract::Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of t...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1978.tb06871.x

    authors: Viukari M,Linnoila M,Aalto U

    更新日期:1978-01-01 00:00:00

  • Traditional Arabian marriages and mental health in a group of outpatient Saudis.

    abstract::This is a prospective study of 150 consecutive outpatients who were either married or divorced. Marriage custom in Saudi Arabia is unique to the culture of that country and several different kinds of marriage are identified: arranged marriage of cousins; marriage of a couple who have not met before consummation; marri...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05090.x

    authors: Chaleby K

    更新日期:1988-02-01 00:00:00

  • Overdose rates in lithium-treated versus antidepressant-treated outpatients.

    abstract::Our clinical experience that lithium is an agent used infrequently for self-poisoning was investigated. The rate at which such overdoses occurred was determined from hospital records. A retrospective case notes study then compared overdose rates in patients taking lithium versus patients on antidepressant medication. ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01555.x

    authors: Waddington D,McKenzie IP

    更新日期:1994-07-01 00:00:00

  • Correlates of addiction-related problems in Kuwait: a cross-cultural view.

    abstract::The promise of adopting a valid and reliable tool for diagnosing addiction-related problems is offered by the Addiction Severity Index (ASI). Socially determined admissions and poor treatment facilities may have biased the representativeness of our sample, though methodological difficulties were minimal. The ASI was u...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb06359.x

    authors: Bilal AM

    更新日期:1988-10-01 00:00:00

  • Is the existence of a forensic psychiatry justified? On forensic psychiatry in the Scandinavian countries.

    abstract::In Scandinavia during the past decade forensic psychiatry has been the subject of discussions, which have occasionally reached the height of vehement attacks. Changes in penal laws have expressed a declining interest in the cooperation of psychiatrists in the evaluation and treatment of offenders. Scandinavian forensi...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1977.tb00154.x

    authors: Svendsen BB

    更新日期:1977-03-01 00:00:00

  • Neuropsychological test profiles in schizophrenia and non-psychotic depression.

    abstract:OBJECTIVE:The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD:Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a compreh...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2005.00626.x

    authors: Rund BR,Sundet K,Asbjørnsen A,Egeland J,Landrø NI,Lund A,Roness A,Stordal KI,Hugdahl K

    更新日期:2006-04-01 00:00:00

  • The hypothalamic-pituitary-thyroid axis in major depression.

    abstract::We investigated the capacity of several thyroid-axis measures to distinguish between depressed and control subjects and determined whether these variables were related to antidepressant treatment response. We studied 105 subjects who fulfilled the DSM-III-R criteria for a current major depressive episode and 41 volunt...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1997.tb09648.x

    authors: Sullivan PF,Wilson DA,Mulder RT,Joyce PR

    更新日期:1997-05-01 00:00:00

  • Randomized comparative study of group versus individual cognitive behavioural therapy for obsessive compulsive disorder.

    abstract:OBJECTIVE:The primary aim of the study was to compare the effectiveness of group and individual cognitive behaviour therapy (CBT) for obsessive compulsive disorder (OCD). METHOD:One hundred and ten out-patients with OCD were randomly assigned to 15 sessions of either group CBT or individual CBT. Outcome measures were ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析,随机对照试验

    doi:10.1111/j.1600-0447.2010.01613.x

    authors: Jónsson H,Hougaard E,Bennedsen BE

    更新日期:2011-05-01 00:00:00

  • Neuroleptic dose and schizophrenic symptoms. A survey of prescribing practices.

    abstract::A study was conducted to survey the prescribing practices of neuroleptic doses in 100 consecutively hospitalized DSM-III-R schizophrenic patients. The relationship between doses and clinical and symptomatological variables was subsequently analyzed. Patients were evaluated through the Positive and Negative Syndrome Sc...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01606.x

    authors: Peralta V,Cuesta MJ,Caro F,Martinez-Larrea A

    更新日期:1994-11-01 00:00:00

  • Factors predicting readmissions in personality disorders and other nonpsychotic illnesses. A retrospective study on 64 first-ever admissions to the Psychiatric Clinic of Turku, Finland.

    abstract::A retrospective study of factors predicting readmissions and follow-up treatment was undertaken of all first-ever episodes of inpatient care (age under 65), excluding psychotic and organic mental disorders, during 1987 and 1988 in University Psychiatric Clinic in Turku City Hospital, Finland. The cohort consisted of 6...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1995.tb09557.x

    authors: Korkeila JA,Karlsson H,Kujari H

    更新日期:1995-08-01 00:00:00

  • Subjective and external assessments of quality of life in schizophrenia: relationship to insight.

    abstract:OBJECTIVE:This study assessed the manner in which insight influenced schizophrenic patients' evaluation of their objective life conditions and the concurrent validity between patients' and clinicians' assessments of patients' global quality of life. METHOD:Forty out-patients who fulfilled DSM-III-R criteria for schizo...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1999.tb00994.x

    authors: Doyle M,Flanagan S,Browne S,Clarke M,Lydon D,Larkin C,O'Callaghan E

    更新日期:1999-06-01 00:00:00

  • Self-rated schizotypal cognitions, psychotic symptoms and the onset of schizophrenia in young people at high risk of schizophrenia.

    abstract:OBJECTIVE:To examine the associations between the Rust Inventory of Schizotypal Cognitions (RISC) and psychotic symptoms measured by the Present State Examination (PSE) and to assess the predictive validity of the RISC for later onset of schizophrenia. METHOD:A total of 154 subjects at high risk for schizophrenia but ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2002.1o175.x

    authors: Miller PM,Lawrie SM,Byrne M,Cosway R,Johnstone EC

    更新日期:2002-05-01 00:00:00

  • Decreased efficacy of combined benzodiazepines and unilateral ECT in treatment of depression.

    abstract::In a retrospective study, 124 patients with depression who were concomitantly receiving ECT and benzodiazepines were compared with patients (matched for age, sex, diagnosis, and laterality of ECT) receiving ECT without benzodiazepines in order to investigate the efficacy of ECT in terms of therapeutic response and len...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1996.tb09832.x

    authors: Jha A,Stein G

    更新日期:1996-08-01 00:00:00