Abstract:
:Successful drug discovery relies on the selection of drug candidates with good in vivo pharmacokinetic (PK) properties as well as appropriate preclinical efficacy and safety profiles. In vivo PK profiling is often a bottleneck in the discovery process. In this review, we focus on the tiered in vivo PK approaches implemented at the Genomics Institute of the Novartis Research Foundation (GNF), which includes snapshot PK, rapid PK and full PK studies. These in vivo PK approaches are well integrated within discovery research, allow tremendous flexibility and are highly efficient in supporting the diverse needs and increasing demand for in vivo profiling. The tiered in vivo PK studies expedite compound profiling and help guide the selection of more desirable compounds into efficacy models and for progression into development.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Li C,Liu B,Chang J,Groessl T,Zimmerman M,He YQ,Isbell J,Tuntland Tdoi
10.1016/j.drudis.2012.09.004subject
Has Abstractpub_date
2013-01-01 00:00:00pages
71-8issue
1-2eissn
1359-6446issn
1878-5832pii
S1359-6446(12)00307-8journal_volume
18pub_type
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