Synergistic antiproliferative and antiangiogenic effects of EGFR and mTOR inhibitors.

Abstract:

:Single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, mainly because escape or resistance mechanisms are activated once a signalling molecule is inhibited. Rational combinations of target-specific agents could counteract this response providing a useful strategy in cancer treatment. In this regard, the EGFR and mTOR inhibitors have been used together to generate a synergistic effect and maximize the efficacy of each individual agent. Overall, the in vivo and in vitro evidences support the utilization of combinations targeting EGFR and mTOR, for malignancies characterized by deregulated EGFR/PI3K/Akt/ mTOR signalling cascade; whereas the clinical experience points out that the assessment of the therapeutic value of such combination awaits further investigations.

journal_name

Curr Pharm Des

authors

Porcelli L,Quatrale AE,Mantuano P,Silvestris N,Rolland JF,Biancolillo L,Paradiso A,Azzariti A

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

918-26

issue

5

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-20120907-15

journal_volume

19

pub_type

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