Abstract:
:In recent years, follow-on biological products (biosimilars) have received much attention from both the biotechnology industry and the regulatory agencies, especially after the passage of the 2010 healthcare reform bill. Unlike the traditional small-molecule drug products, the development of biological products is not only more complicated but also sensitive to small changes (both mean and variation) in procedure/environment during the manufacturing process because of some fundamental differences between drug products and biological products. A small change will have an impact on the quality of the product and consequently the treatment effect. Thus, in addition to the assessment of biosimilarity in average, it was suggested that biosimilarity in variability between biological products should be assessed. In this article, we propose an adapted F-test for homogeneity of variances to assess biosimilarity in variability. We study the performance and concordance of the proposed adapted F-test and compare it with probability-based method by extensive Monte Carlo simulations.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Yang J,Zhang N,Chow SC,Chi Edoi
10.1002/sim.5568subject
Has Abstractpub_date
2013-02-10 00:00:00pages
415-23issue
3eissn
0277-6715issn
1097-0258journal_volume
32pub_type
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