Myotoxic components of snake venoms: their biochemical and biological activities.

Abstract:

:Necrosis of skeletal muscle is produced by two types of snake venom components: single chain peptides consisting of 42-44 amino acid residues and phospholipases A2 representing either single chain proteins or existing as complexes of several enzyme subunits or combined with other nonenzymatic proteins. Vacuolation, lysis and necrosis of skeletal muscle cells are the major pathological effects of these myotoxins. Although the exact mode of action of these toxins is not clear, interactions with the plasma membrane leading to permeability changes for ions and to their complete destruction is evident. The high specificities of some venom phospholipases A2 for skeletal muscle cells suggest a specific binding to certain membrane receptors; however, an enzymatic action on membranes may also be involved.

journal_name

Pharmacol Ther

authors

Mebs D,Ownby CL

doi

10.1016/0163-7258(90)90081-c

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

223-36

issue

2

eissn

0163-7258

issn

1879-016X

pii

0163-7258(90)90081-C

journal_volume

48

pub_type

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