Abstract:
:Several relative risk models for survival time data in drug combination therapy are derived and their properties are discussed. The main intention of this paper is to clarify the differences among the models in order to help to choose the appropriate one in a given situation. The models are motivated by discussing their relation to well-known physiological concepts. In an example of two-drug treatment the models are compared with each other. For this chemotherapy animal survival study, dose-risk surfaces are fitted and optimal drug combinations are estimated. Methods for checking the model assumptions are mentioned.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Kübler J,Schumacher Mdoi
10.1002/sim.4780091216subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1527-39issue
12eissn
0277-6715issn
1097-0258journal_volume
9pub_type
杂志文章abstract::Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects and a set of indiv...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19981030)17:20<2313::aid-s
更新日期:1998-10-30 00:00:00
abstract::In many studies, a K degree of freedom large sample chi2 test is used to assess the effect of treatment on a multivariate response, such as an omnibus T2-like test of a difference between two treatment groups in any of K repeated measures. Alternately, a K df chi2 test may be used to test the equality of K+1 groups in...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1637
更新日期:2003-11-15 00:00:00
abstract::Many quantitative assay measurements of metabolites of environmental toxicants in clinical investigations are subject to left censoring due to values falling below assay detection limits. Moreover, when observations occur in both unexposed individuals and exposed individuals who reflect a mixture of two distributions ...
journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/sim.2079
更新日期:2005-07-15 00:00:00
abstract::Multi-type recurrent event data arise when two or more different kinds of events may occur repeatedly over a period of observation. The scientific objectives in such settings are often to describe features of the marginal processes and to study the association between the different types of events. Interval-censored m...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1936
更新日期:2005-03-15 00:00:00
abstract::Instrumental variable estimates of causal effects can be biased when using many instruments that are only weakly associated with the exposure. We describe several techniques to reduce this bias and estimate corrected standard errors. We present our findings using a simulation study and an empirical application. For th...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6358
更新日期:2015-02-10 00:00:00
abstract::Summarizing the information of many studies using a meta-analysis becomes more and more important, also in the field of diagnostic studies. The special challenge in meta-analysis of diagnostic accuracy studies is that in general sensitivity and specificity are co-primary endpoints. Across the studies both endpoints ar...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6583
更新日期:2015-12-20 00:00:00
abstract::The "some invalid, some valid instrumental variable estimator" (sisVIVE) is a lasso-based method for instrumental variables (IVs) regression of outcome on an exposure. In principle, sisVIVE is robust to some of the IVs in the analysis being invalid, in the sense of being related to the outcome variable through pathway...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8066
更新日期:2019-04-30 00:00:00
abstract::The coefficient of individual equivalence is a permutation-based measure of agreement between two observers making replicated readings on each subject. It compares the observed disagreement between the observers to the expected disagreement under individual equivalence. Individual equivalence of observers requires tha...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5323
更新日期:2012-09-10 00:00:00
abstract::An important problem in oncology is comparing chemotherapy (chemo) agents in terms of their effects on survival or progression-free survival time. When the goal is to evaluate individual agents, a difficulty commonly encountered with observational data is that many patients receive a chemo combination including two or...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.4249
更新日期:2011-07-10 00:00:00
abstract::Health questionnaires are often built up from sets of questions that are totaled to obtain a sum score. An important consideration in designing questionnaires is to minimize respondent burden. An increasingly popular method for efficient measurement is computerized adaptive testing; unfortunately, many health question...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5936
更新日期:2014-02-10 00:00:00
abstract::Phase II trials often test the null hypothesis H(0): p
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2653
更新日期:2007-03-30 00:00:00
abstract::A new testing approach is described for improving statistical tests of independence in sets of tables stratified on one or more relevant factors in case of categorical (nominal or ordinal) variables. Common tests of independence that exploit the ordinality of one of the variables use a restricted-alternative approach....
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7006
更新日期:2016-11-10 00:00:00
abstract::The use of classification and regression tree (CART) methodology is explored for the diagnosis of patients complaining of anterior chest pain. The results are compared with those previously obtained using correspondence analysis and independent Bayes classification. The technique is shown to be of potential value for ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19970415)16:7<717::aid-sim
更新日期:1997-04-15 00:00:00
abstract::Parameters for latent transition analysis (LTA) are easily estimated by maximum likelihood (ML) or Bayesian method via Markov chain Monte Carlo (MCMC). However, unusual features in the likelihood can cause difficulties in ML and Bayesian inference and estimation, especially with small samples. In this study we explore...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3130
更新日期:2008-05-20 00:00:00
abstract::Genetic networks for gene expression data are often built by graphical models, which in turn are built from pair-wise correlations of gene expression levels. A key feature of building graphical models is the evaluation of conditional independence of two traits, given other traits. When conditional independence can be ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3274
更新日期:2008-08-30 00:00:00
abstract::Health surveillance involves collecting public health data on chronic and infectious diseases to detect changes in disease incidence rates in order to improve public health. Timely detection of disease clusters is essential in prospective public health surveillance. Most existing health surveillance research is based ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3877
更新日期:2011-02-28 00:00:00
abstract::This paper presents a general approach for simultaneously assessing, from serial data, diagnostic consistency, interrater reliability and incidence of a strictly progressive disease. Observed data are viewed as incomplete: diagnostic errors are not distinguished from true diagnoses. We introduce a broad class of model...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780070306
更新日期:1988-03-01 00:00:00
abstract::For many HIV-infected patients, use of antiretroviral therapy (ART) results in a sustained suppression of plasma viral load to undetectable levels. However, due to lack of antigenic stimulation, this may also result in a gradual loss of cell-mediated immune (CMI) responses that help control HIV infection. In concept, ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2555
更新日期:2007-02-10 00:00:00
abstract::A survey is conducted at w of K selection units or lists, e.g. health care institutions or weeks in a year, to estimate N, the total number of individuals with particular characteristics. Our estimator utilizes two items determined for each survey participant: the number, u, among the w lists in S and the number, j, a...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3614
更新日期:2009-07-30 00:00:00
abstract::Non-linear mixed-effects models (NLMEMs) are used to improve information gathering from longitudinal studies and are applied to treatment evaluation in disease-evolution studies, such as human immunodeficiency virus (HIV) infection. The estimation of parameters and the statistical tests are critical issues in NLMEMs s...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2950
更新日期:2007-11-30 00:00:00
abstract::Blinded estimation of variance allows for changing the sample size without compromising the integrity of the trial. Some of the methods that estimate the variance in a blinded manner either make untenable assumptions or are only applicable to two-treatment trials. We propose a new method for continuous endpoints that ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2070
更新日期:2005-06-30 00:00:00
abstract::With reference to a real data on cataract surgery, we discuss the problem of zero-inflated circular-circular regression when both covariate and response are circular random variables and a large proportion of the responses are zeros. The regression model is proposed, and the estimation procedure for the parameters is ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7496
更新日期:2018-01-15 00:00:00
abstract::The problem for assessing biosimilarity and drug interchangeability of follow-on biologics (biosimilar products) is studied. Unlike the generic products, the development of biosimilar products is much more complicated because of fundamental differences in functional structures and manufacturing processes. As a result,...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5571
更新日期:2013-02-10 00:00:00
abstract::The identification of new adverse drug reactions is often tricky. For a given case, the relationship between drug exposure and symptom occurrence is usually questionable. It could be investigated statistically from a series of drug-event association cases with an independence test between the two variables. Analysing ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780100621
更新日期:1991-06-01 00:00:00
abstract::Suppression of premature ventricular contractions (PVCs) is one of the goals of antiarrhythmic therapy. In a clinical trial, however, it may be difficult to distinguish antiarrhythmic drug effect from spontaneous variation in PVCs. We propose the application of linear regression to PVC histories to ascertain drug effe...
journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章
doi:10.1002/sim.4780020305
更新日期:1983-07-01 00:00:00
abstract::The matched case-control designs are commonly used to control for potential confounding factors in genetic epidemiology studies especially epigenetic studies with DNA methylation. Compared with unmatched case-control studies with high-dimensional genomic or epigenetic data, there have been few variable selection metho...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.5694
更新日期:2013-05-30 00:00:00
abstract::We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables. Our joint model provides a flexible approach to handle informative dropout in quantile regression. A M...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6393
更新日期:2015-03-30 00:00:00
abstract::A common problem encountered in many medical applications is the comparison of survival curves. Often, rather than comparison of the entire survival curves, interest is focused on the comparison at a fixed point in time. In most cases, the naive test based on a difference in the estimates of survival is used for this ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2864
更新日期:2007-10-30 00:00:00
abstract::Knee replacement is the most commonly used surgical treatment for knee arthritis. It has been reported that knee replacement rates vary across both regions and counties. This paper used data from Medicare patients to develop explanations for the variation. One problem with our data is that we do not have patient level...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0258(19960915)15:17<1875::AID-S
更新日期:1996-09-15 00:00:00
abstract::The induced smoothing technique overcomes the difficulties caused by the non-smoothness in rank-based estimating functions for accelerated failure time models, but it is only natural when the estimating function has Gehan's weight. For a general weight, the induced smoothing method does not provide smooth estimating f...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6415
更新日期:2015-04-30 00:00:00