Abstract：
:Smoking has been posited as a possible risk factor for amyotrophic lateral sclerosis (ALS), but large population-based studies of patients with incident disease are still needed. The authors performed a population-based case-control study in the Netherlands between 2006 and 2009, including 494 patients with incident ALS and 1,599 controls. To prove the relevance of population-based incidence cohorts in case-control studies, the authors compared results with those from cohorts including patients with prevalent ALS and referral patients. Subjects were sent a questionnaire. Multivariate analyses showed an increased risk of ALS among current smokers (odds ratio = 1.38, 95% confidence interval (CI): 1.02, 1.88) in the incident patient group only. Cox regression models showed that current smoking was also independently associated with shorter survival (hazard ratio = 1.51, 95% CI: 1.07, 2.15), explaining the lack of association in the prevalent and referral patient groups. Current alcohol consumption was associated with a reduced risk of ALS (incident patient group: odds ratio = 0.52, 95% CI: 0.40, 0.75). These findings indicate that current smoking is associated with an increased risk of ALS, as well as a worse prognosis, and alcohol consumption is associated with a reduced risk of ALS, further corroborating the role of lifestyle factors in the pathogenesis of ALS. The importance of population-based incident patient cohorts in identifying risk factors is highlighted by this study.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
de Jong SW,Huisman MH,Sutedja NA,van der Kooi AJ,de Visser M,Schelhaas HJ,Fischer K,Veldink JH,van den Berg LHdoi
10.1093/aje/kws015subject
Has Abstractpub_date
2012-08-01 00:00:00pages
233-9issue
3eissn
0002-9262issn
1476-6256pii
kws015journal_volume
176pub_type
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-10-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009382
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113897
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pub_type： 杂志文章
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更新日期：1998-03-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009423
更新日期：1998-01-15 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008995
更新日期：1996-10-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm245
更新日期：2008-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115444
更新日期：1989-12-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.aje.a008886
更新日期：1996-12-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh139
更新日期：2004-05-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi051
更新日期：2005-02-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115992
更新日期：1991-07-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112936
更新日期：1980-05-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2018-11-01 00:00:00
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journal_title：American journal of epidemiology
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doi：10.1093/oxfordjournals.aje.a114382
更新日期：1986-08-01 00:00:00
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更新日期：2012-07-01 00:00:00
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更新日期：1999-11-01 00:00:00
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更新日期：2007-04-01 00:00:00
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更新日期：1997-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-10-01 00:00:00
