Abstract：
BACKGROUND:Port-wine stains (PWS) may thicken and darken with age. Little is known about the pathogenesis and epidemiology of PWS hypertrophy because of the lack of large studies. OBJECTIVE:We sought to assess the prevalence and characteristics of patients with hypertrophic PWS. METHODS:Medical records and clinical photographs of all patients with PWS visiting our clinic between 2005 and 2009 were examined to identify hypertrophy. Patients were sent questionnaires regarding their hypertrophic PWS. RESULTS:In all, 335 patients (age 0-81 years; 69% female) with PWS were included. Hypertrophy was found in 68 patients (20%; 32 male, 36 female) and classified as thickened (5%), nodular (8%), or both (7%). Color of hypertrophic PWS was mainly red (50%) or purple (44%). Patients with hypertrophy in their PWS were mostly (68%) older than 40 years, and rarely (7%) younger than 20 years. When older than 50 years, 71% of all patients had hypertrophy in their PWS. Median age of onset of PWS hypertrophy was 31 years (12 years for thickened, 39 years for nodular). LIMITATIONS:This was a retrospective study in a selected population. CONCLUSION:Hypertrophy is an important feature in the development of PWS and affects a majority of patients older than 50 years. Depth of color of the PWS is associated with hypertrophy, whereas location and size appear not to be related. More attention should be drawn to therapy and prevention of hypertrophic PWS. Diffuse thickening and nodules should be distinguished, as a different age of onset may indicate different pathomechanisms.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
van Drooge AM,Beek JF,van der Veen JP,van der Horst CM,Wolkerstorfer Adoi
10.1016/j.jaad.2012.05.027subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1214-9issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(12)00587-7journal_volume
67pub_type
杂志文章abstract：:Retiform hemangioendothelioma is a rare low-grade angiosarcoma of the skin. It shares some clinical characteristics with Kaposi's sarcoma, a tumor with known human herpesvirus 8 (HHV-8) association. We report a case of retiform hemangioendothelioma in which we detected HHV-8 DNA sequences. ...
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