Abstract:
:Multiple hormonal and neural signals are generated by ingested nutrients that limit meal size and suppress postmeal eating. However, the availability of sugar-rich and fat-rich foods can override these satiation/satiety signals and lead to overeating and obesity. The palatable flavor of these foods is one factor that promotes overeating, but sugar and fat also have postoral actions that can stimulate eating and increase food preferences. This is revealed in conditioning studies in which rodents consume flavored solutions paired with intragastric sugar or fat infusions. The significant flavor preferences and increased intake produced by the nutrient infusions appear to involve stimulatory gut-brain signals, referred to here as appetition signals, that are distinct from the satiation signals that suppress feeding. Newly developed rapid conditioning protocols may facilitate the study of postoral appetition processes.
journal_name
Appetitejournal_title
Appetiteauthors
Sclafani Adoi
10.1016/j.appet.2012.05.024subject
Has Abstractpub_date
2013-12-01 00:00:00pages
454-8eissn
0195-6663issn
1095-8304pii
S0195-6663(12)00193-6journal_volume
71pub_type
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