Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.

Abstract:

:Congenital heart defects (CHD) are the third leading cause of death in children <1 year of age in Mexico where there is a high prevalence of the 677C → T polymorphism of the MTHFR gene. This is important because the homozygous 677T/T MTHFR gene and deficiency of folic acid (FA) intake have been associated with CHD. Our objective was to analyze the possible association between the genotype 677T/T of the MTHFR gene and supplementation of FA in Mexican women with the presence of complex CHD in their children. We analyzed genotypes of 31 mothers of children with complex CHD (group I) and 62 mothers of healthy children (group II) and investigated FA supplementation during pregnancy in both study groups. Allele frequencies in group I were 41.9 % for C and 58.1 % for T and 22.6 % for genotype frequencies CC, 38.7 % for CT, and 38.7 % for TT. Allele frequencies in group II were 63.7 % for C and 36.3 % for T and 38.7 % for genotype frequencies CC, 50 % for CT and 11.3 % for TT. Both populations are in Hardy-Weinberg equilibrium. Odds ratio for having a child with a complex CHD was 5.9, p = 0.008 (95 % CI 1.67; 20.63) for the TT genotype. FA supplementation at any time during pregnancy was 90.3 and 87.9 % in groups II and I respectively (p > 0.05). Association was found between the maternal genotype (677/TT MTHFR) with the presence of complex CHD in their offspring. No differences in FA supplementation during any stage were found between groups.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Balderrábano-Saucedo NA,Sánchez-Urbina R,Sierra-Ramírez JA,García-Hernández N,Sánchez-Boiso A,Klunder-Klunder M,Arenas-Aranda D,Bravo-Hernández G,Noriega-Zapata P,Vizcaíno-Alarcón A

doi

10.1007/s00246-012-0380-y

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

46-51

issue

1

eissn

0172-0643

issn

1432-1971

journal_volume

34

pub_type

杂志文章
  • Right Ventricular Enlargement In Utero: Is It Coarctation?

    abstract::Antenatal diagnosis of right heart enlargement has a wide spectrum of differential diagnosis from maternal, placental and fetal causes, and outcomes of all are not known. Coarctation of the aorta is in the differential diagnosis of right heart enlargement. In our study, we focused to measure multiple cardiac dimension...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-015-1168-7

    authors: Sivanandam S,Nyholm J,Wey A,Bass JL

    更新日期:2015-10-01 00:00:00

  • Fetal interventions for congenital heart disease in Brazil.

    abstract::Fetal interventions have been performed for some congenital heart diseases. However, these procedures have not gained wide acceptance due to concerns about their efficacy and safety. The aim of this study was to report on a preliminary experience with fetal cardiac interventions in Brazil. Twenty-two cardiac intervent...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0792-3

    authors: Pedra SR,Peralta CF,Crema L,Jatene IB,da Costa RN,Pedra CA

    更新日期:2014-03-01 00:00:00

  • Quadrivalvar replacement in infantile Marfan syndrome.

    abstract::Marfan syndrome (MS) is a connective tissue disease involving the cardiovascular, ocular, and the musculoskeletal systems. MS has variable phenotypic expression and is most often diagnosed in adult life. Infantile-onset MS is rare and is associated with severe cardiovascular manifestations; there is an extremely high ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-006-0066-4

    authors: Strigl S,Quagebeur JM,Gersony WM

    更新日期:2007-09-01 00:00:00

  • Preclosure pressure gradients predict patent ductus arteriosus patients at risk for later left pulmonary artery stenosis.

    abstract::The objective of this study was to evaluate the incidence of pre-existing catheterization left pulmonary artery (LPA) gradients and correlation of these gradients with later LPA stenosis after successful patent ductus arteriosus (PDA) occlusion. We performed a single-center review of 130 patients with PDA closure from...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-009-9448-8

    authors: Gowda ST,Kutty S,Ebeid M,Qureshi AM,Worley S,Latson LA

    更新日期:2009-10-01 00:00:00

  • Tripartite Assessment of Right Ventricular Systolic Function in Persistent Pulmonary Hypertension of the Newborn.

    abstract::Non-invasive evaluation of right ventricular (RV) systolic function in neonates with pulmonary hypertension (PH) with traditional metrics including RV fractional area change (FAC) and tricuspid annular systolic plane excursion (TAPSE) has improved outcomes. Apical three-chamber (3C) RV-FAC, a novel tripartite assessme...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-020-02376-1

    authors: Chikkabyrappa SM,Critser P,Roane J,Buddhe S,Tretter JT

    更新日期:2020-08-01 00:00:00

  • Intrapericardial and retrocardial implantation of implantable cardioverter-defibrillator lead in a child with type 3 long QT syndrome.

    abstract::A 6-year-old girl with type 3 long QT syndrome was safely and successfully implanted with an implantable cardioverter-defibrillator (ICD) system. Prior to implantation, she had experienced uncontrollable life-threatening arrhythmia in spite of high-dose administration of mexiletine. An ICD coil lead for transvenous us...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-011-0065-y

    authors: Ichikawa Y,Iwamoto M,Yanagi S,Masuda M

    更新日期:2011-10-01 00:00:00

  • Cardiac regeneration in children.

    abstract::Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising fro...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-015-1120-x

    authors: Rupp S,Schranz D

    更新日期:2015-04-01 00:00:00

  • Dual atrioventricular nodal non-reentrant tachycardia in a child undergoing repair of ventricular septal defect.

    abstract::Paroxysmal non-reentrant supraventricular tachycardia due to double ventricular response through antegrade dual atrioventricular nodal pathways by a single atrial excitation has been reported in limited adult cases but not in pediatric patients with structurally normal hearts or with congenital heart defects. We repor...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0326-4

    authors: Takahashi K,Nakayashiro M,Ganaha H

    更新日期:2013-03-01 00:00:00

  • Cor triatriatum with unroofed coronary sinus and persistent left superior vena cava associated with atrial tachycardia.

    abstract::A 2-year-old girl with cor triatriatum with unroofed coronary sinus and persistent left superior vena cava underwent preoperative radiofrequency catheter ablation for atrial tachycardia attack that developed after admission to our hospital. The procedure was not successful. Cryoablation was successfully performed duri...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-002-0376-0

    authors: Sato T,Suzuki K,Umemura J,Takahashi Y,Tomimoto K

    更新日期:2003-09-01 00:00:00

  • Aneurysm of the fossa ovalis in infants: a pathologic study.

    abstract::An aneurysm of the fossa ovalis was identified at autopsy in 17 infants. In each case the aneurysm of the fossa ovalis was considered to have resulted from excessive elevation of pressure in that atrium contralateral to the side into which the aneurysm bulged. The aneurysms were divided into two types: intrinsic (thre...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02282740

    authors: Topaz O,Feigl A,Edwards JE

    更新日期:1985-01-01 00:00:00

  • Transient third-degree atrioventricular block in a 4-year-old child with familial dysautonomia.

    abstract::The case of a transient third degree atrioventricular block in a 4-year-old patient with familial dysautonomia is reported. A review of the literature follows with analysis of the significance of arrhythmias in the natural history of the patient with familial dysautonomia. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00793955

    authors: Rutkowski M,Axelrod FB,Danilowicz D

    更新日期:1992-07-01 00:00:00

  • Transcatheter management of subtotal cor triatriatum sinister: a rare anomaly.

    abstract::Subtotal cor triatriatum sinister (partially divided left atrium) is characterized by a membrane dividing the left atrium into two portions: a dorsal accessory proximal chamber that receives part of the pulmonary venous return and a small restrictive defect in the membrane that obstructs blood flow from the accessory ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9205-4

    authors: Sivakumar K,Satish R,Tailor K,Coelho R

    更新日期:2008-07-01 00:00:00

  • Beta-blocker therapy failures in symptomatic probands with genotyped long-QT syndrome.

    abstract::Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS proba...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0567-3

    authors: Chatrath R,Bell CM,Ackerman MJ

    更新日期:2004-09-01 00:00:00

  • A medical link between local maternity hospitals and a tertiary center using telediagnosis with fetal cardiac ultrasound image transmission.

    abstract::Information and communication technology has been widely applied to various fields, including clinical medicine. We report here a telediagnosis system using ultrasound image transmission. The effect of telediagnosis, using a medical link between local maternity hospitals and our children's medical center, was verified...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00246-013-0834-x

    authors: Hishitani T,Fujimoto Y,Saito Y,Sugamoto K,Hoshino K,Ogawa K

    更新日期:2014-04-01 00:00:00

  • A patient with kawasaki disease showing severe tricuspid regurgitation and left ventricular dysfunction in the acute phase.

    abstract::We encountered a male aged 6 years 4 months with Kawasaki disease (KD) with severe tricuspid regurgitation and left ventricular dysfunction in the acute phase. His clinical course and findings of endomyocardial biopsy suggested that myocarditis was the cause of left ventricular dysfunction and responsible for the deve...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-002-0137-0

    authors: Shinohara T,Tanihira Y

    更新日期:2003-01-01 00:00:00

  • Isolated left pulmonary artery in absent pulmonary valve syndrome.

    abstract::A very rare combination including tetralogy of Fallot (TOF), absent pulmonary valve, and isolated left pulmonary artery is described. A 4-month-old girl presented with mild cyanosis and severe dyspnea. Echocardiography established the diagnosis of TOF and absent pulmonary valve with severe pulmonary regurgitation and ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9282-4

    authors: Wu L

    更新日期:2008-11-01 00:00:00

  • Loss of Consciousness in the Young Child.

    abstract::In the very young child (less than eight years of age), transient loss of consciousness represents a diagnostic and management dilemma for clinicians. While most commonly benign, syncope may be due to cardiac dysfunction which can be life-threatening. It can be secondary to an underlying ion channelopathy, cardiac inf...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-020-02498-6

    authors: Villafane J,Miller JR,Glickstein J,Johnson JN,Wagner J,Snyder CS,Filina T,Pomeroy SL,Sexson-Tejtel SK,Haxel C,Gottlieb J,Eghtesady P,Chowdhury D

    更新日期:2021-01-02 00:00:00

  • Mechanism of cardioprotection: what can we learn from females?

    abstract::This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via n...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-010-9877-4

    authors: Murphy E,Lagranha C,Deschamps A,Kohr M,Nguyen T,Wong R,Sun J,Steenbergen C

    更新日期:2011-03-01 00:00:00

  • Bartonella henselae endocarditis in a child.

    abstract::14-year-old white male with a past medical history of congenital bicuspid aortic valve, Streptococcus viridans endocarditis, and pulmonary valve homograft presented with culture-negative endocarditis. Molecular studies identified the causative organism as Bartonella henselae and subsequent serologic studies supported ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-006-1383-3

    authors: Pitchford CW,Creech CB 2nd,Peters TR,Vnencak-Jones CL

    更新日期:2006-11-01 00:00:00

  • The conduction system in Pompe's disease.

    abstract::We report our findings in the microscopic examination of the conduction system in four infants with glycogen storage disease, one of whom had adequate electrophysiologic studies. The electrophysiologic studies in the latter case showed P-A and A-H intervals at the lower limits of normal, but the H-V interval was just ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02265613

    authors: Bharati S,Serratto M,DuBrow I,Paul MH,Swiryn S,Miller RA,Rosen K,Lev M

    更新日期:1982-01-01 00:00:00

  • Interruption of aortic arch and hypoplastic left heart syndrome.

    abstract::Interruption of the aortic arch and hypoplastic left heart syndrome in the same patient is exceptional. In the combined collections of the Registry of Cardiovascular Disease (St. Paul, Minnesota, U.S.A.) and the Registry of Congenital Heart Defects of the Rijksuniversiteit Gent (Gent, Belgium) three specimens were fou...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00798068

    authors: Devloo-Blancquaert A,Titus JL,Edwards JE,Vallaeys JH,De Gezelle HR,Coppens M

    更新日期:1995-11-01 00:00:00

  • Pressure-regulated volume control vs volume control ventilation in infants after surgery for congenital heart disease.

    abstract::The objective of this investigation was to compare how two modes of positive pressure ventilation affect cardiac output, airway pressures, oxygenation, and carbon dioxide removal in children with congenital heart disease in the immediate postoperative period. The investigation used a one group pretest-post-test study ...

    journal_title:Pediatric cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002460010210

    authors: Kocis KC,Dekeon MK,Rosen HK,Bandy KP,Crowley DC,Bove EL,Kulik T

    更新日期:2001-05-01 00:00:00

  • Angiotensin-converting enzyme inhibitor nephrotoxicity in neonates with cardiac disease.

    abstract::Angiotensin-converting enzyme inhibitors (ACEi) are commonly used for pediatric cardiology patients. However, studies examining their safety for neonates with cardiac disease are scarce. The current study aimed to test the hypothesis that ACEi-mediated nephrotoxicity occurs in neonates and may be underappreciated in t...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0813-2

    authors: Lindle KA,Dinh K,Moffett BS,Kyle WB,Montgomery NM,Denfield SD,Knudson JD

    更新日期:2014-03-01 00:00:00

  • Longitudinal myocardial deformation is selectively decreased after pediatric cardiac transplantation: a comparison of children 1 year after transplantation with normal subjects using velocity vector imaging.

    abstract::The transplanted heart experiences numerous hemodynamic changes during and after cardiac transplantation. This study sought to evaluate the left ventricular myocardial mechanics in the pediatric heart transplant population using Velocity Vector Imaging (VVI). This study retrospectively evaluated 28 heart transplant re...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0205-z

    authors: Kailin JA,Miyamoto SD,Younoszai AK,Landeck BF

    更新日期:2012-06-01 00:00:00

  • First case of intracardiac foregut cyst occurring in the left-ventricular outflow tract.

    abstract::An 11 day-old female infant underwent resection of a mass in the subaortic region secondary to critical aortic stenosis. At 3 months of age, recurrent severe left-ventricular outflow obstruction (LVOT) in the setting of heart failure prompted redo surgery, and the resected mass revealed an intracardiac foregut cyst, w...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0623-y

    authors: Huang JH,Rudzinski ER,Minette MS,Langley SM

    更新日期:2013-01-01 00:00:00

  • Prevalence of obesity among patients with congenital and acquired heart disease.

    abstract::Overweight and obesity rates have risen dramatically in the United States, with subsequent detrimental comorbidity risks. The rates for obesity among children with congenital and acquired heart disease have rarely been reported. A retrospective cross-sectional study was conducted to determine the prevalence of overwei...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-011-0049-y

    authors: Shustak RJ,McGuire SB,October TW,Phoon CK,Chun AJ

    更新日期:2012-01-01 00:00:00

  • Absent right atrioventricular connection and double-inlet ventricle due to an unbalanced familial 8:13 chromosome translocation: a cautionary tale.

    abstract::A two-year-old child who had had palliative surgery as a neonate for an absent right atrioventricular connection and double-inlet ventricle was shown to be developmentally retarded. Trisomy for the short arm of chromosome 8 was demonstrated, resulting from a familial 8:13 translocation, with a high risk of recurrence....

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02306750

    authors: Burn J,Baraitser M,Hughes DT,Saldana-Garcia P,Taylor JF

    更新日期:1984-01-01 00:00:00

  • Tetralogy of Fallot in a patient with Killian-Pallister syndrome.

    abstract::Killian-Pallister syndrome is a rare dysmorphic condition characterized by specific clinical manifestations and tetrasomy 12p. Although the association of this condition with congenital heart disease has been previously documented, no cases have been reported in association with Fallot's tetralogy. We report one such ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002469900420

    authors: Grech V,Parascandalo R,Cuschieri A

    更新日期:1999-03-01 00:00:00

  • Aneurysm of the ventricular membranous septum: serial echocardiographic studies.

    abstract:OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0572-6

    authors: Miyake T,Shinohara T,Nakamura Y,Fukuda T,Tasato H,Toyohara K,Tanihira Y

    更新日期:2004-07-01 00:00:00

  • Utility of Doppler tissue imaging-derived indices in identifying subclinical systolic ventricular dysfunction in children with restrictive cardiomyopathy.

    abstract::Restrictive cardiomyopathy (RCM) is characterized by irreversible diastolic dysfunction with preserved systolic function. The aim of this study was to investigate the presence of impaired ventricular contractility even in the presence of normal ejection fraction (EF) in children with RCM. Longitudinal Doppler tissue v...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-011-9948-1

    authors: Sasaki N,Garcia M,Lytrivi I,Ko H,Nielsen J,Parness I,Srivastava S

    更新日期:2011-06-01 00:00:00