Abstract:
:Disruptions in the sleep-wake cycle and the circadian system have been found in a wide range of psychiatric disorders and are generally correlated with clinical severity and diminished quality of life. Emerging evidence suggests similar disturbances may be found in attention-deficit/hyperactivity disorder (ADHD). Here we review the available literature on across the day fluctuations in ADHD-related processes in terms of; (i) time of day effects on behavior and activity; (ii) morningness-eveningness chronotypology; (iii) sleep/wake rhythms; and (iv) rhythmicity in neuroendocrine and neurophysiological responsiveness. On this basis, we propose a neurobiological framework to guide future study, which sees circadian effects in ADHD, along with other aspects of ADHD arousal-related deficits (e.g., cognitive energetic deficits), as being the result of dysregulated locus coeruleus function. Based on this perspective specific recommendations for future research are presented.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Imeraj L,Sonuga-Barke E,Antrop I,Roeyers H,Wiersema R,Bal S,Deboutte Ddoi
10.1016/j.neubiorev.2012.04.007subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1897-919issue
8eissn
0149-7634issn
1873-7528pii
S0149-7634(12)00072-3journal_volume
36pub_type
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journal_title:Neuroscience and biobehavioral reviews
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