[Efficacy of the dipeptide N(2)-L-Alanyl-L-glutamine in traumatic patients admitted to the ICU: a prospective, randomized, double-blind, multicentre study].

Abstract:

HYPOTHESIS:the endovenous administration of glutamine, independently of the type of nurtrition received, can reduce the ICU length of stay, the incidence of infections and the mortality in the traumatic patients admitted to the ICU. OBJECTIVES:The main objective is to assess the efficacy of glutamine suplementation, given intravenously, to reduce the incidence of infectious complications, mortality and ICU length of stay in the traumatic patients admitted to the ICU. Other objectives are: 1) to assess the efficacy of glutamine in different groups of patients according to the severity and the plasma levels of glutamine. 2) Record all the adverse events due to the intravenous administration of glutamine. METHODS:prospective, randomized, doble-blind and multicenter study with two parallel groups: placebo and treatment group. The patients who fulfill the inclusion criteria will receive either glutamine or placebo, independently of the type on nutrition. Glutamine will be administered as a pharmaconutrient at 0.5 g/kg/day during 5 days as a continous perfusion.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Pérez-Bárcena J,Marsé P,Cervera M,Frontera G,Llompart-Pou JA,Raurich JM,García de Lorenzo A

doi

10.1590/S0212-16112012000100013

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

116-22

issue

1

eissn

0212-1611

issn

1699-5198

pii

S0212-16112012000100013

journal_volume

27

pub_type

杂志文章,多中心研究,随机对照试验
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