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Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial.

Abstract：

STUDY DESIGN:Randomized controlled trial with single-blinded primary outcome assessment. OBJECTIVES:To determine the efficacy and safety of autologous incubated macrophage treatment for improving neurological outcome in patients with acute, complete spinal cord injury (SCI). SETTING:Six SCI treatment centers in the United States and Israel. METHODS:Participants with traumatic complete SCI between C5 motor and T11 neurological levels who could receive macrophage therapy within 14 days of injury were randomly assigned in a 2:1 ratio to the treatment (autologous incubated macrophages) or control (standard of care) groups. Treatment group participants underwent macrophage injection into the caudal boundary of the SCI. The primary outcome measure was American Spinal Injury Association (ASIA) Impairment Scale (AIS) A-B or better at ≥6 months. Safety was assessed by analysis of adverse events (AEs). RESULTS:Of 43 participants (26 treatment, 17 control) having sufficient data for efficacy analysis, AIS A to B or better conversion was experienced by 7 treatment and 10 control participants; AIS A to C conversion was experienced by 2 treatment and 2 control participants. The primary outcome analysis for subjects with at least 6 months follow-up showed a trend favoring the control group that did not achieve statistical significance (P=0.053). The mean number of AEs reported per participant was not significantly different between the groups (P=0.942). CONCLUSION:The analysis failed to show a significant difference in primary outcome between the two groups. The study results do not support treatment of acute complete SCI with autologous incubated macrophage therapy as specified in this protocol.

journal_name

Spinal Cord

journal_title

Spinal cord

authors

Lammertse DP,Jones LA,Charlifue SB,Kirshblum SC,Apple DF,Ragnarsson KT,Falci SP,Heary RF,Choudhri TF,Jenkins AL,Betz RR,Poonian D,Cuthbert JP,Jha A,Snyder DA,Knoller N

doi

10.1038/sc.2012.39

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

661-71

issue

eissn

1362-4393

issn

1476-5624

pii

sc201239

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial.