Abstract:
BACKGROUND:Leptin, an adipocyte-produced cytokine, interacts with various hormones, including those of the hypothalamic-pituitary-adrenal axis. Fibromyalgia is a syndrome characterized by widespread pain accompanied by tenderness. The pathogenesis involves a disturbance in pain processing and transmission by the central nervous system, leading to a general increase in pain perception. OBJECTIVES:To analyze potential changes in leptin levels among female fibromyalgia patients compared with healthy controls, and to evaluate the changes in leptin levels during treatment. METHODS:Sixteen female fibromyalgia patients were recruited. Patients underwent clinical evaluation, physical examination, including manual dolorimetry, and were evaluated regarding quality of life, pain, fatigue, anxiety and depression. Plasma leptin levels were determined by ELISA. Patients were offered standard treatment for fibromyalgia. Clinical evaluation and leptin determination were repeated after three months. RESULTS:No significant difference was observed between leptin levels among fibromyalgia patients and controls; no significant correlation was observed between leptin levels and clinical parameters reflecting fibromyalgia severity; and no significant change was observed in leptin levels over three months of treatment. These results did not change after adjustment of leptin levels for body mass index values. CONCLUSIONS:The results of the present study do not support the existence of a significant relationship between leptin and fibromyalgia pathogenesis. Increasing the sample size or examining the interaction between leptin and additional hormones⁄mediators of metabolism and body weight control may yet uncover significant information in this field.
journal_name
Pain Res Managjournal_title
Pain research & managementauthors
Ablin JN,Aronov N,Shimon I,Kanety H,Pariente C,Aloush V,Elkayam O,Levartovsky Ddoi
10.1155/2012/350654subject
Has Abstractpub_date
2012-03-01 00:00:00pages
89-92issue
2eissn
1203-6765issn
1918-1523journal_volume
17pub_type
杂志文章abstract::Background. Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL. Methods. Data are from the Center for Oral H...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/5491923
更新日期:2017-01-01 00:00:00
abstract:Objective:To explore the effect of "selecting acupoints by site" on the synergy effect of "acupoint compatibility" according to the clinical efficacy of acupuncture treatment of patients with gastroparesis. Methods:A total of 99 patients who met the diagnostic criteria for gastroparesis were enrolled in 3 clinical cen...
journal_title:Pain research & management
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2020/8751958
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Although a variety of national organizations such as the Canadian Pain Society, the American Pain Society and the Joint Commission on Accreditation of Health Care Organizations have advanced the idea that pain should be assessed on a routine basis, there is little evidence that systematic pain assessment inf...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2009/638585
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sough...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/796161
更新日期:2013-11-01 00:00:00
abstract:Background:The purpose of this study was to examine the effect of Mulligan mobilization technique (MMT) on pain, range of motion (ROM), functional level, kinesiophobia, depression, and quality of life (QoL) in older adults with neck pain (NP). Methods:Forty-two older adults with NP were included in the study, and they...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/2856375
更新日期:2018-05-15 00:00:00
abstract:Objective:In this study, we compared the effects of intermittent pneumatic compression along with conventional treatment with cold-pack treatment along with conventional treatment on clinical outcomes in patients with knee osteoarthritis. Methods:Eighty-nine patients with knee osteoarthritis participated in this study...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/8514808
更新日期:2019-05-02 00:00:00
abstract::The purpose of the present review is to correlate recent knowledge of the role of peripheral ionotropic glutamate receptors in the temporomandibular joint and muscle pain from animal and human experimental pain models with findings in patients. Chronic pain is common, and many people suffer from chronic pain condition...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2005/860354
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Reports indicate that characteristics of older adults with chronic pain may be different than those of younger persons. OBJECTIVE:To study the pain characteristics of older patients presenting to a tertiary pain clinic for the first time. METHODS:Age, sex and relative contributions of biomedical versus psy...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2008/541963
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:We recently introduced the efficacy safety score (ESS) as a new "call-out algorithm" for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and...
journal_title:Pain research & management
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/9431984
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic pain affects between 30% and 50% of the world population. Our objective was to estimate the prevalence of chronic pain in Brazil, describe and compare differences between pain types and characteristics, and identify the types of therapies adopted and the impact of pain on daily life. ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/4643830
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate the status of work-related musculoskeletal disorders (WMSDs) in nurses working in the hospitals in Xinjiang Uygur Autonomous Region. METHODS:The prevalence of WMSDs since working and in the previous 12 months was evaluated using self-administrated modified musculoskeletal questionnaire based o...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/5757108
更新日期:2017-01-01 00:00:00
abstract::Treatments for obesity have been shown to reduce pain secondary to weight loss. Intestinal microbiota, as an endogenous factor, influences obesity and pain sensitivity but the effect of oral probiotic supplementation on musculoskeletal pain perception has not been studied systematically. The present study examined the...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2016/5080438
更新日期:2016-01-01 00:00:00
abstract:Background:Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG) neurons and the spin...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/3740162
更新日期:2020-02-10 00:00:00
abstract:BACKGROUND AND AIMS:The inhibitory pathways that play a role in spinal modulation include local interneurons and descending control. Clinical data regarding the role of these pathways in acute pain is lacking. Accordingly, the aim of this study was to evaluate cerebrospinal fluid (CSF) levels of noradrenaline, serotoni...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2017/2752658
更新日期:2017-01-01 00:00:00
abstract:Objectives:The easily performed "cough-trick" (CT) reduces pain during venipuncture (VP), although the underlying mechanism remains unclear. The aim was to investigate the pain-reducing effect of CT during VP in comparison with two distraction methods, as well as under the influence of naloxone. Methods:54 healthy mal...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9459103
更新日期:2019-12-12 00:00:00
abstract:OBJECTIVES:To explore how adolescents' pain coping profiles relate to their expectations regarding psychological treatment recommendations, and to examine patients' functioning and engagement in psychological treatment three months following a multidisciplinary pain clinic evaluation. METHODS:Adolescents and their par...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2011/652853
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery. DESIGN:Te...
journal_title:Pain research & management
pub_type: 临床试验,杂志文章
doi:10.1155/2009/497217
更新日期:2009-03-01 00:00:00
abstract::Pain is one of the commonest reasons why children visit the hospital. Inadequately treated pain in children can negatively affect their physical, psychological, and social well-being; it also places financial burden on families of affected children and healthcare systems in general. Considering the eventual suffering ...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7283473
更新日期:2020-02-13 00:00:00
abstract::Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radi...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2020/7565962
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:Dynamic mechanical allodynia is traditionally induced by manual brushing of the skin. Brushing force and speed have been shown to influence the intensity of brush-evoked pain. There are still limited data available with respect to the optimal stroke number, length, force, angle and speed. Therefore, an autom...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/142582
更新日期:2013-01-01 00:00:00
abstract::The psychological predictors of pain and disability were examined in a sample of people who sustained whiplash injuries during rear-end motor vehicle accidents. Sixty-five patients referred to a specialty pain clinic with a diagnosis of whiplash injury completed measures of depression, anxiety, catastrophizing, pain a...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2002/176378
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Pain clinics tend to see more complex chronic pain patients than primary care settings, but the types of patients seen may differ among practices. OBJECTIVE:The aim of the present observational study was to describe the pain and demographic characteristics of patients attending a university-affiliated terti...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2007/658762
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To provide an overview of the history and pharmacology of cannabis in relation to current scientific knowledge concerning actual and potential therapeutic uses of cannabis preparations and pure cannabinoids. METHODS:The literature on therapeutic uses of cannabis and cannabinoids was assessed with respect to ...
journal_title:Pain research & management
pub_type: 历史文章,杂志文章
doi:10.1155/2001/469629
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Alexithymia is a disturbance in awareness and cognitive processing of affect that is associated with over-reporting of physical symptoms, including pain. The relationship between alexithymia and other psychological constructs that are often associated with pain has yet to be evaluated. OBJECTIVES:The presen...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2009/468321
更新日期:2009-07-01 00:00:00
abstract:Objective:With the aim of developing a chronic pain prevention program, this randomized controlled trial examined whether exercise training combined with increased physical activity more effectively improves pain and physical activity than exercise training alone in community-dwelling older adults without chronic pain....
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/2132039
更新日期:2018-04-05 00:00:00
abstract:Background:Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second ...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2018/6358624
更新日期:2018-02-25 00:00:00
abstract:Objectives:Dexmedetomidine is widely used as an adjunct to general anesthesia. In this study, we evaluated the effects of perioperative dexmedetomidine infusion on postoperative analgesia in patients undergoing lateral thoracotomy for thoracic esophageal cancer. Methods:A total of 62 patients undergoing lateral thorac...
journal_title:Pain research & management
pub_type: 杂志文章,随机对照试验
doi:10.1155/2020/4145893
更新日期:2020-05-06 00:00:00
abstract::Context. Postthoracotomy Ipsilateral Shoulder Pain (IPS) is a common and sometimes intractable pain syndrome. IPS is different from chest wall pain in type, origin, and treatments. Various treatments are suggested or applied for it but none of them is regarded as popular accepted effective one. Objectives. To review d...
journal_title:Pain research & management
pub_type: 杂志文章,评审
doi:10.1155/2016/3652726
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Acetaminophen is one of the most common drugs used for the treatment of pain and fever. OBJECTIVES:To examine the effects of intra-articular (IA) acetaminophen on carrageenan-induced arthritic pain-related behaviour and spinal c-Fos expression in rats. METHODS:The present study was performed using 20 Sprag...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2013/148392
更新日期:2013-09-01 00:00:00
abstract::Staff shortages, deficient knowledge, inappropriate attitudes, demanding workloads, analgesic shortages, and low prioritization of pain management have been identified in earlier studies as the nursing-related barriers to optimal children's pain management. These studies have mainly been undertaken in developed countr...
journal_title:Pain research & management
pub_type: 杂志文章
doi:10.1155/2020/7125060
更新日期:2020-01-20 00:00:00