Antibody-mediated rejection after intestinal transplantation.

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inducible pluripotent stem (iPS) cells derived from somatic cells represent a novel renewable source of tissue precursors. The potential of iPS cells is considered to be at least equivalent to that of human embryonic stem cells, facilitating the treatment or cure of diseases such as diabetes mellitus,...

journal_title：Current opinion in organ transplantation

authors： Robbins RD,Prasain N,Maier BF,Yoder MC,Mirmira RG

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric kidney transplantation has made great strides over the preceding years. It has become an accepted and successful remedy for thousands of patients worldwide. For best outcomes, it must be viewed and treated as a distinct entity from adult transplantation with focus on the unique challenges pa...

journal_title：Current opinion in organ transplantation

authors： Etesami K,Lestz R,Hogen R

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of sensitized heart transplant candidates is rising. Highly sensitized patients are disadvantaged because they encounter longer waiting times to heart transplant. Strategies to reduce their waiting times include waitlist prioritization and desensitization therapies. The purpose of this revi...

journal_title：Current opinion in organ transplantation

authors： Aleksova N,Ross HJ

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, there has been an increasing interest in nonhuman histocompatibility antigens as targets of injury in organ-transplant recipients. This increased interest has been spurred by the fact that human-histocompatibility-antigen-identical kidney transplants also undergo immunological r...

journal_title：Current opinion in organ transplantation

authors： Sumitran-Holgersson S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs. RECENT FINDINGS:With this in mind, we discuss recent issues in adult living-donor liver transplantation, including issues with don...

journal_title：Current opinion in organ transplantation

authors： Yeh H,Olthoff KM

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic...

journal_title：Current opinion in organ transplantation

authors： Sacks S,Lee Q,Wong W,Zhou W

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pneumonia occurs in 8-23% of patients after liver transplantation and contributes considerably to their morbidity and mortality. With the increasing acuity of liver transplantation patients in the current era, pneumonias, particularly ventilator-associated pneumonias, and multidrug-resistant pathogens...

journal_title：Current opinion in organ transplantation

authors： Angarita SAK,Russell TA,Kaldas FM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current evidence supporting the existence of C4d-negative antibody-mediated rejection (AMR) in renal allografts, its potential to cause chronic graft injury, and whether histopathologic features of C4d-negative AMR differ from those of C4d-positive AMR. RECENT FINDINGS:Recently published...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Several expanded criteria for liver transplantation for hepatocellular carcinoma (HCC) have been suggested out of concern that the Milan criteria may be too strict, and thereby exclude patients who could benefit from this surgical procedure. However, most expanded criteria were designed for deceased d...

journal_title：Current opinion in organ transplantation

authors： Lee HW,Suh KS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity. RECENT FINDINGS:We present the status quo picture of the lectin pathway, including the newly discovered member, MAp44 (a.k.a. MAP-1), which may act as a s...

journal_title：Current opinion in organ transplantation

authors： Degn SE,Jensenius JC,Bjerre M

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of currently available immunosuppressive strategies and novel therapeutic developments in pancreas transplantation. RECENT FINDINGS:From 1966 through 2012 more than 30 000 pancreas transplantations have been performed around the world with excellent patient and graft survival. ...

journal_title：Current opinion in organ transplantation

authors： Kimelman M,Brandacher G

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Macrophages are members of the innate immune response. However, their role in the adaptive immune response is not known. The purpose of this review is to highlight our current understanding of macrophage structure and function and how they may participate in allograft injury. RECENT FINDINGS:Studies ...

journal_title：Current opinion in organ transplantation

authors： Mannon RB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the scarcity of clinical trials with de-novo immunosuppression has been typical over the last 2 years, several attempts have been made in drug conversion, dosing optimization, and bioequivalence. On the basis of recent clinical and animal studies, future directions of management and treatment...

journal_title：Current opinion in organ transplantation

authors： Wohlfahrtova M,Viklicky O

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. RECENT FINDINGS:During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or mi...

journal_title：Current opinion in organ transplantation

authors： Alegre ML,Goldstein DR,Chong AS

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion ...

journal_title：Current opinion in organ transplantation

authors： Cheung KP,Kasimsetty SG,McKay DB

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review features articles published during 2018 and 2019 regarding pediatric visceral transplantation in Europe. In this biannual review, the authors identify and summarize key articles pertinent to clinical and research areas. RECENT FINDINGS:There is a trend to a lower use of intestinal transpl...

journal_title：Current opinion in organ transplantation

authors： Andres AM,Ramos E,Hernandez F

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with parenteral nutrition has been standard despite seemingly similar pa...

journal_title：Current opinion in organ transplantation

authors： Sudan D

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune monitoring is needed in small bowel transplantation (SBTx) because of a high incidence of rejection and graft loss, and life-threatening complications of high-dose prophylactic immunosuppression. RECENT FINDINGS:Clinical tests relevant to SBTx include methods to detect antidonor human leukocyt...

journal_title：Current opinion in organ transplantation

authors： Sindhi R,AshokKumar C,Mazariegos G,Nayyar N,Ningappa M,Soltys K,Bond G,Sun Q,Humar A,Abu-Elmagd K,Zeevi A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:B cells are known to play a central role in humoral immunity and to boost cellular immunity, however, in a variety of experimental models, B-cell subsets ameliorate inflammation and autoimmune disease, indicating that they can also play a regulatory role. Here, we highlight the advances in regulatory ...

journal_title：Current opinion in organ transplantation

authors： Kim JI,Rothstein DM,Markmann JF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. This article reviews some recent applications of the many evolvin...

journal_title：Current opinion in organ transplantation

authors： Sarwal MM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation may become clinically feasible once the mechanisms of graft loss and rejection are better understood. Inflammatory reactions to vasculature of grafted pig organs and pancreatic islets have been linked to procoagulant activation and consumption with resulting thrombosis that preclud...

journal_title：Current opinion in organ transplantation

authors： Schmelzle M,Schulte Esch J 2nd,Robson SC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is the leading cause of late morbidity and mortality in heart transplant patients and limits long-term survival. Immunosuppression following cardiac transplantation has traditionally comprised a calcineurin inhibitor in combination with mycophenolate mofetil or aza...

journal_title：Current opinion in organ transplantation

authors： Raichlin E,Kushwaha SS

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T c...

journal_title：Current opinion in organ transplantation

authors： Valujskikh A,Li XC

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Although conceptually unchanged, the evaluation and selection of the liver transplant candidate has seen significant recent advances. Expanding criteria for transplant candidacy, improved diagnostics for risk stratification and advances in prognostic models have paralleled recent changes in allocation...

journal_title：Current opinion in organ transplantation

authors： Kriss M,Biggins SW

更新日期：2021-02-01 00:00:00