Time-course of antibody responses against Coxiella burnetii following acute Q fever.

Abstract:

:Large outbreaks of Q fever in The Netherlands have provided a unique opportunity for studying longitudinal serum antibody responses in patients. Results are presented of a cohort of 344 patients with acute symptoms of Q fever with three or more serum samples per patient. In all these serum samples IgM and IgG against phase 1 and 2 Coxiella burnetii were measured by an immunofluorescence assay. A mathematical model of the dynamic interaction of serum antibodies and pathogens was used in a mixed model framework to quantitatively analyse responses to C. burnetii infection. Responses show strong heterogeneity, with individual serum antibody responses widely different in magnitude and shape. Features of the response, peak titre and decay rate, are used to characterize the diversity of the observed responses. Binary mixture analysis of IgG peak levels (phases 1 and 2) reveals a class of patients with high IgG peak titres that decay slowly and may represent potential chronic cases. When combining the results of mixture analysis into an odds score, it is concluded that not only high IgG phase 1 may be predictive for chronic Q fever, but also that high IgG phase 2 may aid in detecting such putative chronic cases.

journal_name

Epidemiol Infect

authors

Teunis PF,Schimmer B,Notermans DW,Leenders AC,Wever PC,Kretzschmar ME,Schneeberger PM

doi

10.1017/S0950268812000404

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

62-73

issue

1

eissn

0950-2688

issn

1469-4409

pii

S0950268812000404

journal_volume

141

pub_type

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