Abstract:
BACKGROUND:Mexico has a high rate of cervical cancer which represents an important public health issue. The treatment for this disease depends on the extension of the tumor; for the initial stages surgery is recommended, and for locally advanced tumors, a combination of chemotherapy and radiotherapy is used. All this process affects natural antioxidant consumption and Quality of Life (QoL). OBJECTIVE:To find out the effect that supplementation with antioxidants (β-carotene, vitamin C y vitamin E) has on oxidative stress, and quality of life in patient diagnosed with cervical cancer during treatments with cisplatin and radiotherapy. MATERIALS AND METHODS:We conducted a randomized, blind clinical trial in women with cervical cancer whose antineoplasic treatment was radiotherapy in and radiotherapy with cisplatin. Patients were randomly assigned to receive antioxidant therapy or a placebo. Plasma concentrations of malondialdehyde (MDA), free carbonyls, dityrosines, and carbonyl/protein rate in two different moments, before oncologic therapy, and after finishing oncology treatment, we also evaluated food consumption by using a validated food frequency questionnaire and a QOL questionnaire before treatment and after it was over. The effect of the antioxidant treatment was assessed by the use t-student test for independent and paired samples, as well as frequencies and X² for categorical variables. RESULTS:We evaluated 103 patients who were randomly assigned to receive treatment with antioxidants 49 (47.60%) and placebo 54 (52.40%). We did not find statistically significant differences in food or antioxidant consumption according to the food frequency questionnaires. Most of the patients consumed more energy than needed to meet their requirement, but they did not consume enough of most of the antioxidants according to the Recommended Dailiy Allowance (RDA) recommendation. Serum levels of plasma free carbonyls and carbonil/mg of protein ratio were statistically significant (p < 0.009) which shows protein protection regarding oxidative stress in the supplemented group, this information was similar to the one found in the QOL questionnaire, which showed that Global QOL was better in the supplemented group (p < 0.025). Most of the patients had lower α-tocopherol and retinol plasma levels than the recommended values. CONCLUSIONS:Antioxidant supplementation showed to be effective in reducing oxidative stress in proteins, but it did not on food ingestion, patients did not meet their antioxidants requirement in their diets, in spite of an excess in energy consumption. Antioxidant plasma levels in most of the patients were lower than normal. QoL score was better in the supplemented group.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Fuchs-Tarlovsky V,Bejarano-Rosales M,Gutiérrez-Salmeán G,Casillas MA,López-Alvarenga JC,Ceballos-Reyes GMdoi
10.1590/S0212-16112011000400023subject
Has Abstractpub_date
2011-07-01 00:00:00pages
819-26issue
4eissn
0212-1611issn
1699-5198pii
S0212-16112011000400023journal_volume
26pub_type
杂志文章,随机对照试验abstract:UNLABELLED:The National Survey of Family Income and Expenditure (ENIGFAM 2009-2010), showed that a third, and almost two thirds of Guatemalans purchased outside the home breakfast and lunch. OBJECTIVE:To determine the composition, nutritional value and price of breakfast and lunch menus purchased outside the home in u...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.2.7752
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Among the diverse genes associated to type 2 diabetes (T2D), the β-adrenergic receptors are an excellent candidate to study in Mexican population. The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic synd...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.6.7367
更新日期:2014-06-01 00:00:00
abstract::Dual-energy X ray absorptiometry (DEXA) is primarily used in the assessment of bone mineral. However, the transmissions of the two different energy beams in nonbone areas can be processed to calculate the amount of fat and free-fat mass of the soft tissues. We have compared the estimation of body fat mass (FM) by DEXA...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine associations between abdominal obesity (AOb) and the other components of metabolic syndrome (MetS) in young Mexicans in a cross-sectional survey completed during a 4 year period. METHODS:This cross-sectional study reports on components and prevalence of MetS by us...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.171
更新日期:2017-03-30 00:00:00
abstract:BACKGROUND:residents are vulnerable to suffer of dehydration due to physiological changes and the physical and cognitive limitations. AIM:to handle this situation, it has been decided to evaluate the interventions which are carried out for the management of dehydration and low fluid intake in older people living in nu...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.1885
更新日期:2018-12-03 00:00:00
abstract:AIMS:The aim of this study was to assess the food habits and nutritional status of free-living, non-institutionalised, elderly people of Torrevieja, a Spanish city located in the Mediterranean coast. METHODS:Anthropometric and dietary survey (two 24 hour recalls) were assessed in 200 (83 men and 117 women) free-living...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000500038
更新日期:2011-09-01 00:00:00
abstract:Introduction:Introduction: at present, it is precisely the Mediterranean countries whose characteristic lifestyle was recognized as a health paradigm and promoted to the rest of the world, those who are at mostly at risk, in which it becomes necessary the immediate development of strategies based on education that may ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.02685
更新日期:2019-07-02 00:00:00
abstract::Presentation of the methodology used for an anthropometric study on the population of the Canary Islands. Comments on the problems posed and discussion of the ideal solutions to these problems. Evaluation of the calipers used, and establishing of possible bases for study on a national scale. ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract:INTRODUCTION:Gestational diabetes has been associated with obesity later in life. However, reported results have not been consistent and the methods used have shown weakness. OBJECTIVE:To analize prospective and retrospective cohort studies that assess the gestational diabetes effects on adiposity indicators in the of...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2014.29.2.7042
更新日期:2014-02-01 00:00:00
abstract:Introduction:The current COVID-19 pandemic mainly affects older people, those with obesity or other coexisting chronic diseases such as type-2 diabetes and high blood pressure. It has been observed that about 20 % of patients will require hospitalization, and some of them will need the support of invasive mechanical ve...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03180
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Vitamin D and calcium play an important role in peak bone mass acquisition. Recent studies have suggested that vitamin D deficiency in children is widespread, mainly during infancy and adolescent years. However, the vitamin D status at others ages is unsufficiently investigated. OBJECTIVES:To determine the ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2012.27.6.6065
更新日期:2012-11-01 00:00:00
abstract:Introduction:The infl uence of exercise in trained subjects has beneficial effects in the physical fi tness and body composition; however, detraining has an unfavorable effect in all of them. Objective:The current study was designed to ascertain the infl uence of a six week-detraining period on body composition in bot...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.618
更新日期:2017-06-05 00:00:00
abstract:INTRODUCTION:Dietary protein amount and source, hypertrophy resistance training (RT) and anabolicandrogenic steroids (AAS) may affect body weight and plasma and hepatic lipid profile. MATERIAL AND METHODS:157 adult male Wistar rats were randomly distributed in 16 experimental groups resulting in: normal-protein (NP) o...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.1.6055
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to estimate if B12 deficiency is associated with the use of metformin in the elderly diabetics. METHODS:Case-control study in diabetic OP. Cases (n = 137) were defined as elderly with B12 < 221 pmol/L and controls (n = 279) elderly with B12 > 221 pmol/L. Four categories of metform...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.29.6.7405
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Aluminium has lately been implicated as one of the possible causal factors contributing to Alzheimer's disease and other neurodegenerative disorders due to this metal is conducive to oxidative stress in the brain. According to different researches, it has been suggested that silicon may interfere in the toxic...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To determine possible associations between the risk of breast cancer in Brazilian women and demographic, social and economical variables, and past dietary intake. METHODS:A case-control study was conducted in Joinville, Santa Catarina, Brazil, between june and november 2003 involving a group of 33 women rece...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-09-01 00:00:00
abstract::T2DM involves at least two primary pathogenic mechanisms: (a) a progressive decline in pancreatic islet cell function resulting in reduced insulin secretion and (b) peripheral insulin resistance resulting in a decrease in the metabolic responses to insulin. This dynamic interaction between insulin secretion and insuli...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.sup2.6717
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To assess the usefulness of establishing a routine gravimetric as quality assurance after the development of parenteral nutrition (PN) with a gravimetric error less than ± 5%. MATERIAL AND METHODS:Prospective study in which 5 to 8 large volume PN were weighed daily during 2 months and for 4 months all small ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000500018
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:one of the main extradigestive manifestations of celiac disease is the decrease in bone mineral density (BMD). Bone densitometry performed with DXA is the method of choice for BMD assessment. Indications for its use in celiac children are controversial. OBJECTIVE:analyzing BMD and various clinical-analyti...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1510
更新日期:2018-06-04 00:00:00
abstract::Sugars are sweet-flavored carbohydrates that provide energy to the body. The adult brain uses about 140 g of glucose per day, amount which can represent up to 50 of the total number of carbohydrates consumed. In our country the sugar in food consumption pattern remains constant, while the consumption of soft drinks ha...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.sup4.6794
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Nutritional problems develop complications in geriatric patients and increase their morbidity and mortality. Hyperproteic nutritional supplements are one of the options to improve nutritional deficiencies. OBJECTIVES:To assess the beneficial effect and tolerance of one hyperproteic nutritional supplement ...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:the incidence of hospital undernutrition and its consequences for both the patient and the hospital has demanded procedures that ensure the delivery of good-quality hospital nutritional care. On the basis of literature reports, this study aimed to build a hospital nutritional care propositions tha...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.3.9307
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of the glycemic index (GI) on food intake, anthropometric measurements and body composition in subjects with excess body weight. METHODS:Crossover study, in which 17 subjects participated in two study sessions (high GI or low GI). Two daily meals were consumed in laboratory for 30 cons...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章
doi:10.3305/nh.2012.27.4.5845
更新日期:2012-07-01 00:00:00
abstract::Advances in HIV infected patients' treatment have modified their prognosis, making possible to consider their admission to the ICU for acute complications. HIV infected patients show nutritional impairments onto which changes due to acute disease are added. Thus, they are candidate to receive specialized nutritional s...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Sustainability represents a major concern in recent years due to climate change pressure. The diet itself contribute to the emission of greenhouse gasses, water and land use, energy consumption and environment contamination. The Mediterranean diet should be understood not only as a set of foods but also as a cultural ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.2133
更新日期:2018-06-12 00:00:00
abstract::This study provides a gender-based analysis of the Food and Nutrition Education Program, developed in Spain over the last decades of the 20th century, to explore nutrition education messages and strategies aimed at improving the skills of housewives as guardians of family welfare and experts in all areas of household ...
journal_title:Nutricion hospitalaria
pub_type: 历史文章,杂志文章
doi:10.3305/nh.2012.27.4.5815
更新日期:2012-07-01 00:00:00
abstract::La detección de la desnutrición hospitalaria continúa de plena actualidad en la literatura médica y, a pesar de que desde hace dos décadas dejó de ser un tema novedoso, constituye un elemento recurrente en la bibliografía y motivo de abordajes monográficos en congresos y reuniones científicas. ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.251
更新日期:2016-06-30 00:00:00
abstract:UNLABELLED:Recent studies have reflected the prevalence of malnutrition within the hospital sphere. The high incidence of malnutrition in hospitals and the negative effect this has on the evolution of patients, since complications are significantly greater in undernourished patients, make it important to find out the n...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:The beneficial effects of the overall Mediterranean dietary pattern on cardiovascular risk factors and on carbohydrate metabolism are well known; however, it is unclear whether the consumption of olive oil in particular is able to reduce the incidence of type 2 diabetes. OBJECTIVE:To evaluate the specific...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Currently, there is a higher occurrence of biopsychosocial diseases, especially eating disorders, involving different body systems and aspects related to the individual and their social relations. OBJECTIVE:Addressing current and relevant issues about the prevalence, incidence and risk factors for anorexi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112012000200008
更新日期:2012-03-01 00:00:00