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HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens.

Abstract：

:Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily and contribute to cell-cell adhesion and signal modulation in various tissues. In humans, several CEACAMs are targeted by pathogenic bacteria. One peculiar member of this family, CEACAM3, is exclusively expressed by human granulocytes and functions as an opsonin-independent phagocytic receptor for CEACAM-binding bacteria. Here, we will discuss CEACAM3-dependent processes by summarizing recent insight into the phosphotyrosine-based signaling complex formed upon CEACAM3 engagement. Compared to different well-studied phagocytic receptors, such as Fcγ receptors and Dectin-1, CEACAM3 appears as an example of a hemITAM-containing innate immune receptor, which promotes rapid internalization and intracellular destruction of a diverse group of CEACAM-binding bacteria. The particular efficiency of CEACAM3 arises from the direct coupling of upstream activators and downstream effectors of the small GTPase Rac by the cytoplasmic domain of CEACAM3, which co-ordinates actin cytoskeleton re-arrangements and bactericidal effector mechanisms of granulocytes.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Buntru A,Roth A,Nyffenegger-Jann NJ,Hauck CR

doi

10.1016/j.abb.2012.03.020

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

77-83

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(12)00111-7

journal_volume

524

pub_type

杂志文章,评审

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