Abstract:
:The effect of patent ductus arteriosus (PDA) treatment with cyclooxygenase (COX) inhibitors (indomethacin [INDO] and ibuprofen [IBU]) on regional oxygenation requires further clarification. The authors hypothesized that both INDO and IBU reduce regional tissue oxygenation in preterm neonates with PDA but that the risk is not uniform for different tissues and other factors may contribute. Regional cerebral (rSO(2-C)), renal (rSO(2-R)), and mesenteric (rSO(2-M)) tissue oxygenation measured by near-infrared spectroscopy and peripheral arterial oxygen saturation measured by pulse oximetry were recorded simultaneously before, during, and after treatment with the first dose of INDO or IBU in very preterm-born infants with PDA. Tissue-specific fractional oxygen extraction (FOE) was calculated using the rSO(2-C), rSO(2-R), rSO(2-M), and corresponding SpO(2) measurements. The findings showed a significant reduction in rSO(2-C), rSO(2-R), and rSO(2-M) and an increase in regional FOE after treatment with COX inhibitors in approximately one third of the 38 enrolled infants, which were associated with increased baseline regional tissue oxygen saturation (p < 0.01). However, the infants with posttreatment reduction of tissue oxygenation had significantly lower baseline rSO(2-C) (66.7 ± 8.1 vs 69.7 ± 8.1 %), rSO(2-R) (55.2 ± 10.8 vs 62.7 ± 11.8 %) and especially rSO(2-M) (37.8 ± 11.4 vs 46.7 ± 16.0 %) than the neonates with unchanged or increased tissue oxygenation. The two groups did not differ in terms of the risk for posttreatment reduction in regional tissue oxygenation with respect to either INDO or IBU treatment and their respective blood levels. Treatment of PDA with either INDO or IBU is associated with a 30-40 % risk for a reduction in regional tissue oxygenation, which is more pronounced in mesenteric tissue than in cerebral or renal tissue. Despite the inconsistency, reduction of regional tissue oxygenation in preterm infants with PDA is more likely associated with the administration of INDO than with the administration of IBU.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Bhatt M,Petrova A,Mehta Rdoi
10.1007/s00246-012-0309-5subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1307-14issue
8eissn
0172-0643issn
1432-1971journal_volume
33pub_type
杂志文章abstract::Ventriculo-coronary arterial connections are frequently observed in pulmonary atresia with intact interventricular septum. Sustained right ventricular hypertension during cardiac morphogenesis is thought to be responsible for persistence of myocardial sinusoidal-coronary artery connections. Considering an unusual obse...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900305
更新日期:1998-05-01 00:00:00
abstract::Magnetic resonance imaging (MRI) is a powerful tool which enables the visualization of anatomy and the assessment of many physiological aspects of organ function. MRI and magnetic resonance angiography and magnetic resonance spectroscopy will play critical roles in cardiac applications during the next millennium. Thus...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469910003
更新日期:2000-01-01 00:00:00
abstract::A 2-year-old girl with cor triatriatum with unroofed coronary sinus and persistent left superior vena cava underwent preoperative radiofrequency catheter ablation for atrial tachycardia attack that developed after admission to our hospital. The procedure was not successful. Cryoablation was successfully performed duri...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-002-0376-0
更新日期:2003-09-01 00:00:00
abstract::Despite improved outcomes following modifications to the Fontan technique, significant morbidity and mortality persist. We sought to determine if abnormal pre-Fontan catheterization hemodynamic data will predict postoperative prolonged hospital stay (PHLOS) and adverse post-discharge outcomes. This is a retrospective ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02430-y
更新日期:2020-12-01 00:00:00
abstract::The epidemiologic data for pediatric hypertrophic cardiomyopathy (HCM) needs to be periodically updated as diagnostic techniques and management strategies improve. Herein, the incidence, prevalence, and mortality rates of pediatric HCM in a population-based treatment system are described. Patients aged ≤ 17 years and ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02472-2
更新日期:2020-10-03 00:00:00
abstract::Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the numerous studies undertaken to functionally characterize these TFs, their exact role in different...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02099-y
更新日期:2019-06-01 00:00:00
abstract::We undertook a study to identify the hemodynamic significance of a Doppler-derived gradient across a stenotic pulmonary valve. Furthermore, we attempted to define the optimal plane for velocity data acquisition. A total of 17 children with valvar pulmonary stenosis were evaluated using Doppler echocardiography. Flow-v...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02081678
更新日期:1989-07-01 00:00:00
abstract::We present a 2-month-old male infant with thrombosis in the superior vena cava and pericardium due to transient protein C deficiency. Protein C deficiency was related to sepsis and hepatitis-induced liver function impairment. The patient's cardiac anatomy was otherwise normal. The patient was referred to us with signs...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-006-1265-8
更新日期:2006-07-01 00:00:00
abstract::Inhaled nitric oxide (NO) has been used in the preoperative evaluation of patients with congenital heart disease and pulmonary hypertension. The purpose of this study was to characterize responses in pulmonary vascular resistance (PVR) to oxygen and increasing doses of NO during cardiac catheterization and to determin...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0767-5
更新日期:2005-09-01 00:00:00
abstract::Three infants, each with a clinical picture of dilated cardiomyopathy, underwent endomyocardial biopsy. Immunohistologic analysis revealed chronic myocarditis. In one infant, a postviral etiology of chronic myocarditis could be assessed on the basis of molecular techniques. Therapy with azathioprine and prednisone res...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900292
更新日期:1998-05-01 00:00:00
abstract::Plastic bronchitis (PB) is a poorly understood disease that can complicate any underlying pulmonary disease. However, it appears to most often occur in patients with surgically palliated congenital heart disease, particularly after the Fontan procedure. Few data exist about the prevalence and etiology of PB in this po...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0430-5
更新日期:2013-02-01 00:00:00
abstract::The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic pa...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1463-y
更新日期:2016-12-01 00:00:00
abstract::Arrhythmias in pregnancy are becoming more common given more available and effective medical, ablation and device treatment options. Several changes associated with pregnancy, increased blood volume, cardiac output, and heart rate secondary to an increased sympathetic state, facilitate more frequent occurrences of arr...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-015-1232-3
更新日期:2015-10-01 00:00:00
abstract::Embryonic development is a tightly regulated process, and many families of genes functions to provide a regulatory genetic network to achieve such a program. The homeobox genes are an extensive family that encodes transcription factors with a characteristic 60-amino acid homeodomain. Mutations in these genes or in the...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0179-x
更新日期:2012-08-01 00:00:00
abstract::Mid-cavity obstruction of the systemic venous atrium developed after the Mustard operation in a child with transposition of the great arteries. Balloon dilatation (BD) was performed twice, to a maximum theoretical transverse diameter of 18 mm. Each time obstruction was initially relieved, but recurred within months. T...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02076341
更新日期:1983-04-01 00:00:00
abstract::A surge in cortisol levels is seen after surgery with cardiopulmonary bypass (CPB). Based on evidence of attenuation of the cortisol response to repeated stress in other settings, we hypothesized that the magnitude of cortisol increase in children after a second exposure to CPB would be reduced. Serial cortisol levels...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1959-8
更新日期:2019-01-01 00:00:00
abstract::In August 2010, the Nit-Occlud® Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud® Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 E...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-016-1502-8
更新日期:2017-02-01 00:00:00
abstract::Horseshoe lung is a rare malformation that is often associated with lung hypoplasia and/or vascular anomalies. We describe a 10-year-old girl with horseshoe lung and unique left pulmonary vein. This is the first reported case with this vascular feature. The patient presented with signs and symptoms of severe pulmonary...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9735-4
更新日期:2010-08-01 00:00:00
abstract::A vascular approach for balloon aortic dilatation in infants is of major concern due to the high risk of femoral artery injury. To overcome this problem, a surgical right carotid artery (RCA) approach has been advocated. No reports are available on RCA after neonatal cutdown. Since 1990, RCA cutdown has been performed...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010202
更新日期:2001-05-01 00:00:00
abstract::A two-year-old child who had had palliative surgery as a neonate for an absent right atrioventricular connection and double-inlet ventricle was shown to be developmentally retarded. Trisomy for the short arm of chromosome 8 was demonstrated, resulting from a familial 8:13 translocation, with a high risk of recurrence....
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02306750
更新日期:1984-01-01 00:00:00
abstract::Systemic candidiasis developed in a seven-week-old premature baby after 6 weeks treatment with antibiotics for suspected septicemia. At that time the echocardiogram showed a dense layer of echoes posteriorly to the anterior tricuspid leaflet during atrial systole. The diagnosis of Candida endocarditis with vegetations...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02281007
更新日期:1983-01-01 00:00:00
abstract::A primary rhabdomyosarcoma of the heart observed in a 3-week-old infant, provides an opportunity to review this rare clinical entity; 61 reported cases are collated. The more common sites are right ventricle, left atrium, and right atrium; the tumour may protrude into the cavity and cause obstruction. Echocardiography...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02265621
更新日期:1982-01-01 00:00:00
abstract::Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associa...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1633-6
更新日期:2017-10-01 00:00:00
abstract::Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms a...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1245-y
更新日期:2016-01-01 00:00:00
abstract::A 16-year-old boy with anomalous origin of the left coronary artery from the pulmonary artery, Bland-White-Garland syndrome, underwent a mammary artery bypass grafting to the left coronary artery (LCA) together with closure of the stenosed origin of the left coronary artery. A residual LCA to pulmonary artery fistula ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469910028
更新日期:2000-03-01 00:00:00
abstract::Over the past decade, revolutionary advances in ultrasound imaging technology have allowed the study of the evolution of congenital heart disease during fetal life. The frustration arising from watching the prenatal progression of severe semilunar valve obstructions and therapy-refractory fetal arrhythmias has prompte...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-001-0197-6
更新日期:2002-05-01 00:00:00
abstract::Various surgical techniques have been proposed for the repair of supravalvular pulmonary stenosis (SVPS) in pediatric populations. Whereas growth potential should be promised, excessive expansion under the presence of undiminished high pulmonary arterial pressure should be avoided. The authors applied all-autologous t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0698-0
更新日期:2013-10-01 00:00:00
abstract::Identification of heart transplant recipients at highest risk for a poor outcome could lead to improved posttransplantation survival. A chart review of primary heart transplantations from 1993 to 2006 was performed. Analysis was performed to evaluate the risk of graft loss for those with a transplantation age less tha...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-0077-7
更新日期:2012-01-01 00:00:00
abstract::Hospital volume has been associated with improved outcomes in congenital cardiac surgery. However, the relationship between hospital volume and hospitalization cost remains unclear. This study examines the relationship between hospital surgical volume and hospitalization costs, while accounting for measures of quality...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0987-2
更新日期:2015-01-01 00:00:00
abstract::Anomalous origin of left pulmonary artery (ALPA) from aorta with atrial septal defect (ASD) is a rare congenital cardiac malformation. We report a case of ALPA from the aorta with ASD in a 1.8-kg baby. Repair was needed at an early age due to progressive congestive heart failure. Surgical correction was performed with...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-008-9234-z
更新日期:2008-07-01 00:00:00