Abstract:
OBJECTIVE:To model the uptake phase of T(1)-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values. METHODS:The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary bed, two distinct compartments for renal intravascular and extravascular Gd tracer, and uses a small-vessel haematocrit value of 24%. Four physiological parameters can be estimated: regional filtration K ( trans ) (ml min(-1) [ml tissue](-1)), perfusion F (ml min(-1) [100 ml tissue](-1)), blood volume v ( b ) (%) and mean residence time MRT (s). From these are found the filtration fraction (FF; %) and total GFR (ml min(-1)). Fifteen healthy volunteers were imaged twice using oblique coronal slices every 2.5 s to determine the reproducibility. RESULTS:Using parenchymal ROIs, group mean values for renal biomarkers all agreed with published values: K ( trans ): 0.25; F: 219; v ( b ): 34; MRT: 5.5; FF: 15; GFR: 115. Nominally cortical ROIs consistently underestimated total filtration (by ~50%). Reproducibility was 7-18%. Sensitivity analysis showed that these fitted parameters are most vulnerable to errors in the fixed parameters kidney T(1), flip angle, haematocrit and relaxivity. CONCLUSIONS:These renal biomarkers can potentially measure renal physiology in diagnosis and treatment. KEY POINTS:• Dynamic contrast-enhanced magnetic resonance imaging can measure renal function. • Filtration and perfusion values in healthy volunteers agree with published normal values. • Precision measured in healthy volunteers is between 7 and 15%.
journal_name
Eur Radioljournal_title
European radiologyauthors
Tofts PS,Cutajar M,Mendichovszky IA,Peters AM,Gordon Idoi
10.1007/s00330-012-2382-9subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1320-30issue
6eissn
0938-7994issn
1432-1084journal_volume
22pub_type
杂志文章abstract:OBJECTIVES:To investigate whether the addition of nitroglycerine to transcatheter arterial (chemo)embolization (TAE/TACE) can increase the delivery and effectiveness of TAE/TACE in patients with hepatocellular carcinoma (HCC) by dual-energy CT. METHODS:HCC patients (BCLC stage A or B) were randomized to (n = 51) or no...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-012-2484-4
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To develop recommendations that can be used as guidance for standardized approach regarding indications, patient preparation, sequences acquisition, interpretation and reporting of magnetic resonance imaging (MRI) for diagnosis and grading of pelvic floor dysfunction (PFD). METHODS:The technique included cri...
journal_title:European radiology
pub_type: 共识发展会议,杂志文章
doi:10.1007/s00330-016-4471-7
更新日期:2017-05-01 00:00:00
abstract::This study aimed to evaluate the influence of a new navigator technique (3D MAG) on navigator efficiency, total acquisition time, image quality and diagnostic accuracy. Fifty-six patients with suspected coronary artery disease underwent free breathing navigator gated coronary MRA (Intera, Philips Medical Systems, 1.5 ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2731-z
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:To evaluate the utility of CT perfusion (CTP) for the assessment of superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis in patients with Moyamoya syndrome (MMS). SUBJECTS AND METHODS:Twenty-four consecutive MMS patients, who underwent unilateral STA-MCA bypass surgery, received CTP before ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3802-4
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:In dual-source CT, dual-energy (DE) performance is affected by various X-ray tube voltage combinations with and without tin filter (Sn). The purpose of this study was to assess the utility of the 80/150 Sn kV voltage combination in terms of image artefact and radiation dose for DECT gout protocol, compared w...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5622-9
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery d...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-014-3164-3
更新日期:2014-07-01 00:00:00
abstract::Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis is a rare and specific entity referred to as Herlyn-Werner-Wunderlich syndrome. It usually presents after menarche with remittent pelvic pain and a palpable pelvic mass due to hematocolpos. It rarely presents with primary infertility in early a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1085-8
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Cerebral blood flow (CBF) estimates from arterial spin labelling (ASL) show unexplained variability in older populations. We studied the impact of variation of haematocrit (Hct) on CBF estimates in a tri-ethnic elderly population. MATERIALS AND METHODS:Approval for the study was obtained from the Fulham Res...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06096-w
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:To validate a visual rating scale of frontal atrophy with quantitative imaging and study its association with clinical status, APOE ε4, CSF biomarkers, and cognition. METHODS:The AddNeuroMed and ADNI cohorts were combined giving a total of 329 healthy controls, 421 mild cognitive impairment patients, and 28...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4101-9
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. METHODS:Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = ...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-015-3973-z
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Cortical biopsy is the cornerstone to reveal a cause of unexplained dysfunction of the kidney transplant. Nevertheless, only a few studies have reported the biopsy technique with its performance. We described a novel technique of ultrasound (US)-guided kidney transplant biopsy using cortex-only view and analyze...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5910-4
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:This tertiary care experience examines the utility of magnetic resonance neurography (MRN) in the management of peripheral trigeminal neuropathies. MATERIALS AND METHODS:Seventeen patients with clinically suspected peripheral trigeminal neuropathies (inferior alveolar nerve and lingual nerve) were imaged uni...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4182-5
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2779-0
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification of Alzheimer's disease (AD), frontotemporal dementia (FTD), and controls. METHODS:This retrospective study used MRI data from 24 early-onset AD an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4691-x
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To assess epiphyseal growth plate closure of the knee for forensic age estimation using an ultrasound (US)-based method and to compare the findings with MRI. METHODS:Thirty-three healthy male individuals (age, 14.4-19.3 years) were prospectively evaluated for epiphyseal growth plate closure of the right kne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07343-1
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVES:To evaluate the accuracy of high-pitch delayed enhancement (DE) CT for the assessment of myocardial viability with MRI as the reference standard. METHODS:Twenty-four patients (mean age 66.9 ± 9.2 years) with coronary artery disease underwent DE imaging with 128-slice dual-source CT (prospective electrocardi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2149-8
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To assess variability of the average standard uptake value (SUV) computed by varying the number of hottest voxels within an (18)F-fluorodeoxyglucose ((18)F-FDG)-positive lesion. This SUV metric was compared with the maximal SUV (SUV(max): the hottest voxel) and peak SUV (SUV(peak): SUV(max) and its 26 neighb...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3222-x
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:At a European Society of Neuroradiology (ESNR) Annual Meeting 2015 workshop, commonalities in practice, current controversies and technical hurdles in glioma MRI were discussed. We aimed to formulate guidance on MRI of glioma and determine its feasibility, by seeking information on glioma imaging practices f...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-018-5314-5
更新日期:2018-08-01 00:00:00
abstract::Since improvement in the material, true aneurysms and pseudoaneurysm formations have become relatively rare complications after femoro-popliteal reconstruction with polytetrafluoroethylene (PTFE) grafts. We report a case of late graft rupture and pseudoaneurysm formation within the straight femoral part of a femoro-po...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050909
更新日期:1999-01-01 00:00:00
abstract::Carcinoid heart disease is a frequent complication of the carcinoid syndrome, usually presenting as right-sided valvular heart disease. Although the diagnosis is most often made with cardiac ultrasound, MRI and CT are valuable techniques for diagnosing carcinoid heart disease. ...
journal_title:European radiology
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2236-1
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:The objective was to evaluate the initial experience and safety of magnetic resonance imaging (MRI)-guided transcranial cryoablation in cystic metastatic brain tumours. MATERIAL AND METHODS:Seven cystic metastatic brain tumours in six patients were treated with cryoablation. The approval from the local ethic...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-009-1554-8
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:Duchenne muscular dystrophy (DMD) is the most common and severe dystrophinopathy. DMD carriers rarely present with clinical symptoms, but may suffer from cardiac involvement. Because echocardiographic findings are inconsistent and cardiac magnetic resonance imaging (CMRI) data are limited, this study sought ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3694-3
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To correlate hepatic and splenic CT perfusion parameters with hepatic venous pressure gradient (HVPG) measurements in patients with cirrhosis. METHODS:Twenty-one patients with cirrhosis (males, 17; females, 4; mean ± SD age, 57 ± 7 years) underwent hepatic and splenic perfusion CT on a 320-detector row volu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4788-x
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:This study compared 68Gallium-prostate-specific-membrane-antigen based Positron-emission-tomography (68Ga-PSMA-PET) and 99metastabletechnetium-3,3-diphospho-1,2-propanedicarbonacid (99mTc-DPD-SPECT) in performing skeletal staging in prostate cancer (PC) patients and evaluated the additional value of the informa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4994-6
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:High radiation dose during CT perfusion (CTp) studies contributes to prevent CTp application in daily clinical practice. This work evaluates the consequences of scan delay on perfusion parameters and provides guidelines to help reducing the radiation dose by choosing the most appropriate delay. METHODS:Fift...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-019-06259-9
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:We assessed the additional value of contrast-enhanced CT versus US for evaluation of acute cervical inflammatory masses and choosing treatment strategy. METHODS:We retrospectively reviewed 210 files of paediatric patients admitted with an acute inflammatory neck mass from 2005 to 2008 (M:F = 108:102, mean a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1563-7
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship of dual-phase dual-energy CT (DE-CT) and tumour size in the evaluation of the response to anti-EGFR therapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:Dual-phase DE-CT was performed in 31 patients with NSCLC before the onset of anti-EGFR (erlotinib)...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4092-6
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To determine the utility of stretched exponential diffusion model in characterisation of the water diffusion heterogeneity in different tumour stages of nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Fifty patients with newly diagnosed NPC were prospectively recruited. Diffusion-weighted MR imaging was ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3535-9
更新日期:2015-06-01 00:00:00
abstract::The aim of this study was to assess the efficacy of a superparamagnetic iron oxide, ferumoxides, in the detection and characterization of focal nodular hyperplasia (FNH) on MR conventional spin-echo (SE), fast spin-echo (FSE) and gradient-echo (GRE) images. Fourteen adults with 27 FNHs were evaluated at 1.5 T before a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050879
更新日期:1999-01-01 00:00:00