Analysis of the sequences flanking the translational start sites of Plasmodium falciparum.

Abstract:

:The 5' and 3' regions adjacent to the initiation codon in 22 Plasmodium falciparum sequences were examined. A 5' consensus sequence (AAAA/ATG) was found. Although P. falciparum non-translated DNA is A-rich, A occurred significantly more frequently in the 4 positions preceding the initiation ATG than in adjacent non-translated DNA, suggesting that this consensus sequence has functional significance in the initiation of translation. This region has similarities with the equivalent sequences in yeast and Drosophila but differs markedly from that in vertebrates. No significant bias in nucleotide frequencies was found 3' to the initiation codon.

journal_name

Mol Biochem Parasitol

authors

Saul A,Battistutta D

doi

10.1016/0166-6851(90)90112-y

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

55-62

issue

1

eissn

0166-6851

issn

1872-9428

pii

0166-6851(90)90112-Y

journal_volume

42

pub_type

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