[Treatment alternatives in massive hemorrhage].

Abstract:

:Massive hemorrhage is the main cause of mortality and morbidity in trauma patients, and is one of the most important causes in any patient following major surgery. Conventional treatment consists of volume replacement, including the transfusion of blood products, so that tissue perfusion and oxygenation may be maintained. Associated hypothermia, acidosis and coagulopathy is a lethal triad. This review focuses on the latest therapeutic management of massive hemorrhage. The authors advocate the use of crystalloids as per protocol (controlled volumes) in order to achieve a systolic blood pressure of 85mmHg. The administration of the three blood products (red cells, plasma, and platelets) should be on a 1:1:1 basis. Where possible, this in turn should be guided by thromboelastography performed at point of care near the patient. Coagulopathy can occur early and late. With the exception of tranexamic acid, the cost-benefit relationships of the hemostatic agents, such as fibrinogen, prothrombin complex, and recombinant F VII, are subject to discussion.

journal_name

Med Intensiva

journal_title

Medicina intensiva

authors

Fernández-Hinojosa E,Murillo-Cabezas F,Puppo-Moreno A,Leal-Noval SR

doi

10.1016/j.medin.2011.11.010

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

496-503

issue

7

eissn

0210-5691

issn

1578-6749

pii

S0210-5691(11)00317-2

journal_volume

36

pub_type

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