Calcium phosphate cements as drug delivery materials.

Abstract:

:Calcium phosphate cements are used as synthetic bone grafts, with several advantages, such as their osteoconductivity and injectability. Moreover, their low-temperature setting reaction and intrinsic porosity allow for the incorporation of drugs and active principles in the material. It is the aim of the present work to: a) provide an overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system, and b) identify the most significant achievements. The drugs or active principles associated to calcium phosphate cements are classified in three groups, i) low molecular weight drugs; ii) high molecular weight biomolecules; and iii) ions.

journal_name

Adv Drug Deliv Rev

authors

Ginebra MP,Canal C,Espanol M,Pastorino D,Montufar EB

doi

10.1016/j.addr.2012.01.008

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1090-110

issue

12

eissn

0169-409X

issn

1872-8294

pii

S0169-409X(12)00011-7

journal_volume

64

pub_type

杂志文章,评审
  • Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids.

    abstract::Hydrogels are synthetic or natural polymer networks that closely mimic native extracellular matrices. As hydrogel-based vehicles are being increasingly employed in therapeutic cell delivery, two inherent traits of most common hydrogels, namely low cell affinity and high cell constraint, have significantly drawn the at...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2010.02.001

    authors: Wang C,Varshney RR,Wang DA

    更新日期:2010-06-15 00:00:00

  • Biopolymer stereocomplexes.

    abstract::A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on s...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(03)00042-5

    authors: Slager J,Domb AJ

    更新日期:2003-04-25 00:00:00

  • Microdialysis assessment of drug delivery systems for vitreoretinal targets.

    abstract::Posterior segment drug delivery challenges inherent in the treatment of many sight-threatening diseases have become increasingly apparent. Therapeutic interventions for ocular diseases such as neovascular retinopathies, inflammatory and/or infectious diseases may involve drug delivery to vitreoretinal targets. An impo...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2005.09.008

    authors: Duvvuri S,Rittenhouse KD,Mitra AK

    更新日期:2005-12-13 00:00:00

  • Molecular imaging in stem cell-based therapies of cardiac diseases.

    abstract::In the past 15years, despite that regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantifying transplanted cells within the he...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.07.012

    authors: Li X,Hacker M

    更新日期:2017-10-01 00:00:00

  • Thioredoxin 1 delivery as new therapeutics.

    abstract::Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effec...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2009.01.003

    authors: Nakamura H,Hoshino Y,Okuyama H,Matsuo Y,Yodoi J

    更新日期:2009-04-28 00:00:00

  • Surface engineering of inorganic nanoparticles for imaging and therapy.

    abstract::Many kinds of inorganic nanoparticles (NPs) including semiconductor, metal, metal oxide, and lanthanide-doped NPs have been developed for imaging and therapy applications. Their unique optical, magnetic, and electronic properties can be tailored by controlling the composition, size, shape, and structure. Interaction o...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2012.08.015

    authors: Nam J,Won N,Bang J,Jin H,Park J,Jung S,Jung S,Park Y,Kim S

    更新日期:2013-05-01 00:00:00

  • Gene delivery nanoparticles to modulate angiogenesis.

    abstract::Angiogenesis is naturally balanced by many pro- and anti-angiogenic factors while an imbalance of these factors leads to aberrant angiogenesis, which is closely associated with many diseases. Gene therapy has become a promising strategy for the treatment of such a disordered state through the introduction of exogenous...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.11.003

    authors: Kim J,Mirando AC,Popel AS,Green JJ

    更新日期:2017-09-15 00:00:00

  • Bovine mastitis and intramammary drug delivery: review and perspectives.

    abstract::Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are n...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(01)00160-0

    authors: Gruet P,Maincent P,Berthelot X,Kaltsatos V

    更新日期:2001-09-01 00:00:00

  • Tip-enhanced Raman scattering--Targeting structure-specific surface characterization for biomedical samples.

    abstract::Tip-enhanced Raman scattering (TERS) has become a powerful tool for nanoscale structural analysis for several branches of organic, inorganic, and biological chemistry. This highly sensitive technique enables molecular characterization with a lateral resolution far beyond Abbe's diffraction limit and correlates structu...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2015.06.007

    authors: Sharma G,Deckert-Gaudig T,Deckert V

    更新日期:2015-07-15 00:00:00

  • Approaches for the preparation of non-linear amphiphilic polymers and their applications to drug delivery.

    abstract::Amphiphilic polymers are particularly useful for drug delivery because of their ability to self-assemble into discrete aggregates. While this behavior has been studied in depth for simple linear block copolymer amphiphiles, recent advances in synthetic methodologies have provided efficient routes to amphiphilic polyme...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2012.03.011

    authors: Wang Y,Grayson SM

    更新日期:2012-06-15 00:00:00

  • Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers.

    abstract::Traditional anticancer therapies are often unable to completely eradicate the tumor bulk due to multi-drug resistance (MDR) of cancers. A number of mechanisms such as micro-environmental stress and overexpression of drug efflux pumps are involved in the MDR process. Hence, therapeutic strategies for overcoming MDR are...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2018.04.005

    authors: Zhou G,Latchoumanin O,Hebbard L,Duan W,Liddle C,George J,Qiao L

    更新日期:2018-09-01 00:00:00

  • Fibrosis imaging: Current concepts and future directions.

    abstract::Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suf...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.10.013

    authors: Baues M,Dasgupta A,Ehling J,Prakash J,Boor P,Tacke F,Kiessling F,Lammers T

    更新日期:2017-11-01 00:00:00

  • Carbon nanotubes for biomedical imaging: the recent advances.

    abstract::This article reviews the latest progresses regarding the applications of carbon nanotubes (CNTs), including single-walled carbon nanotubes (SWNTs) and multi-walled carbon nanotubes (MWNTs), as multifunctional nano-probes for biomedical imaging. Utilizing the intrinsic band-gap fluorescence of semi-conducting single-wa...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2013.10.002

    authors: Gong H,Peng R,Liu Z

    更新日期:2013-12-01 00:00:00

  • Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.

    abstract::Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.06.012

    authors: Farah S,Anderson DG,Langer R

    更新日期:2016-12-15 00:00:00

  • Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates.

    abstract::A great deal of interest has surrounded the activities of monoclonal antibodies (mAbs), and mAb-drug, toxin and radionuclide conjugates for the treatment of human cancers. In the last few years, a number of new mAb-based reagents have been clinically approved (Rituxan, Herceptin, and Panorex), and several others are n...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(01)00206-x

    authors: Senter PD,Springer CJ

    更新日期:2001-12-31 00:00:00

  • Controlling liposome blood clearance by surface-grafted polymers.

    abstract::The incorporation of polymer-lipid conjugates, initially using PEG and subsequently other selected flexible, hydrophilic polymers, into lipid bilayers gives rise to sterically stabilized liposomes that exhibit reduced blood clearance and concomitant changes in tissue distribution largely because of reduced, but not el...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(97)00136-1

    authors: Woodle MC

    更新日期:1998-06-08 00:00:00

  • The biology of mucus: Composition, synthesis and organization.

    abstract::In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a complex aqueous fluid that owes its viscoelastic, lubricating and hydration properties to the glycoprotein mucin combined with ele...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.09.023

    authors: Bansil R,Turner BS

    更新日期:2018-01-15 00:00:00

  • Nuclear import of polypeptides, polynucleotides and supramolecular complexes.

    abstract::Nuclear import of macromolecules or particles is a strictly regulated phenomenon that is now understood in some depth at the molecular level. Transport across nuclear membranes is controlled by nuclear pores, with the involvement of cytoplasmic receptors and accessory molecules. Each nuclear pore complex is an assembl...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(98)00050-7

    authors: Pouton CW

    更新日期:1998-10-05 00:00:00

  • Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse.

    abstract::Messenger RNA and small interfering RNA are attractive modalities for curing diseases by complementation or knock-down of proteins. For success of these RNAs, a drug delivery system (DDS) is required to control a pharmacokinetics, to enhance cellular uptake, to overcome biological membranes, and to release the cargo i...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2020.07.001

    authors: Tanaka H,Sakurai Y,Anindita J,Akita H

    更新日期:2020-01-01 00:00:00

  • Impact of pharmacodynamic variability on drug delivery(1).

    abstract::Modern pharmaceutical delivery systems are intended to produce plasma drug concentration versus time profiles that result in optimum therapeutic efficacy and a minimum of drug concentration-dependent adverse effects. To accomplish this requires that the drug delivery rate and temporal profile be based on the pharmacok...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(98)00028-3

    authors: Levy G

    更新日期:1998-09-07 00:00:00

  • Bioengineering strategies for inducing tolerance in autoimmune diabetes.

    abstract::Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specif...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.06.007

    authors: Baekkeskov S,Hubbell JA,Phelps EA

    更新日期:2017-05-15 00:00:00

  • Advancement in integrin facilitated drug delivery.

    abstract::The research of integrin-targeted anticancer agents has recorded important advancements in ingenious design of delivery systems, based either on the prodrug approach, or on nanoparticle carriers, but for now, none of these has reached a clinical stage of development. Past work in this area has been extensively reviewe...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2015.12.001

    authors: Arosio D,Casagrande C

    更新日期:2016-02-01 00:00:00

  • Enhancing patient-level clinical data access to promote evidence-based practice and incentivize therapeutic innovation.

    abstract::Clinical trials are crucial to determining the human safety and efficacy of new therapeutic innovations. Extraordinary amounts of human experiential data are generated over the course of any clinical trial, however, much of these data is never made publicly accessible. Improved, reliable data sharing is essential to i...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2018.01.017

    authors: Fortunato A,Grainger DW,Abou-El-Enein M

    更新日期:2018-01-01 00:00:00

  • Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy.

    abstract::Lanthanide-doped upconverting luminescent nanoparticles (UCNPs) are promising materials for optical imaging-guided drug delivery and therapy due to their unique optical and chemical properties. UCNPs absorb low energy near-infrared (NIR) light and emit high-energy shorter wavelength photons. Their special features all...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2012.05.007

    authors: Shen J,Zhao L,Han G

    更新日期:2013-05-01 00:00:00

  • Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms.

    abstract::Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In th...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.01.003

    authors: Qi S,Craig D

    更新日期:2016-05-01 00:00:00

  • Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes.

    abstract::Over the past few decades, a range of vesicle-based drug delivery systems have entered clinical practice and several others are in various stages of clinical translation. While most of these vesicle constructs are lipid-based (liposomes), or polymer-based (polymersomes), recently new classes of vesicles have emerged t...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2018.10.012

    authors: Kauscher U,Holme MN,Björnmalm M,Stevens MM

    更新日期:2019-01-01 00:00:00

  • Development and applications of photo-triggered theranostic agents.

    abstract::Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased atte...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2010.09.002

    authors: Rai P,Mallidi S,Zheng X,Rahmanzadeh R,Mir Y,Elrington S,Khurshid A,Hasan T

    更新日期:2010-08-30 00:00:00

  • Oral biodrug delivery using cell-penetrating peptide.

    abstract::During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for impr...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2011.12.014

    authors: Khafagy el-S,Morishita M

    更新日期:2012-05-01 00:00:00

  • Mucosal immunity of the gastrointestinal tract and oral tolerance.

    abstract::To guard against disease, mucosal surfaces of the intestinal, respiratory and urogenital tracts are protected by a carefully regulated system of defenses known as the mucosal immune system. The hallmark of mucosal immunity is secretory IgA which can prevent infection and remove antigen crossing the mucosal barrier. Ig...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(98)00042-8

    authors: Simecka JW

    更新日期:1998-12-01 00:00:00

  • Clinical toxicities of nanocarrier systems.

    abstract::Toxicity of nanocarrier systems involves physiological, physicochemical, and molecular considerations. Nanoparticle exposures through the skin, the respiratory tract, the gastrointestinal tract and the lymphatics have been described. Nanocarrier systems may induce cytotoxicity and/or genotoxicity, whereas their antige...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2007.11.007

    authors: Vega-Villa KR,Takemoto JK,Yáñez JA,Remsberg CM,Forrest ML,Davies NM

    更新日期:2008-05-22 00:00:00