Abstract:
:An improved chemical reaction protocol with short time and easy work-up was described here for 2-phenylbenzofuran derivatives. The final purified products, 2-phenylbenzofuran derivatives 5a-g and the intermediate diols 4a-g, were evaluated for their estrogen receptor (ER) binding affinity and selective activity in vitro. Among these fourteen tested compounds, 4g and 5g showed higher binding affinity on ER subtypes, ERα and ERβ. Compound 4g exhibited preferable ERα binding, while 5g was more estrogen selective for ERβ. The molecular docking was also performed to explore the detailed interactive interface between ER and the compounds.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Zhang P,Yang Y,Zheng X,Huang W,Ma Z,Shen Zdoi
10.1248/cpb.60.270subject
Has Abstractpub_date
2012-01-01 00:00:00pages
270-4issue
2eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/60.270journal_volume
60pub_type
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