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Erythrocyte damage of crucian carp (Carassius auratus) caused by microcystin-LR: in vitro study.

Abstract：

:Fish suffer from anemia and hypovolemic hypotensive shock after in vivo exposure with microcystins.However, except for in vivo causes for anemia and hypotension, an in vitro study of fish erythrocytes exposed to MC is necessary. For a better understanding of hematology toxicity of MC, the main aim of the present study was to investigate the toxic effects of microcystin on fish erythrocytes in vitro. Crucian carp erythrocytes were incubated in vitro with microcystin-LR (MC-LR) at doses of 0, 1, 10, 100 and 1,000 nM.The level of lipid peroxidate significantly increased in MC-LR treatment groups. Glutathione decreased after exposure to MC-LR. The activities of antioxidative enzymes, including superoxide dismutase, catalase,glutathione peroxidase and glutathione-S-transferase,were significantly increased after exposure with MC-LR.The hemolysis was significantly increased, while the activities of acetylcholinesterase, Na?–K?-ATPase and Ca2?–Mg2?-ATPase were significantly decreased. In addition, pathological alterations in agglomerated and jagged erythrocytes were observed in blood smears. The findings indicate that damages to erythrocytes should also be responsible for anemia and hypotensive shock or even death.

journal_name

Fish Physiol Biochem

journal_title

Fish physiology and biochemistry

authors

Zhou W,Liang H,Zhang X

doi

10.1007/s10695-011-9572-2

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

849-58

issue

3

eissn

0920-1742

issn

1573-5168

journal_volume

38

pub_type

杂志文章

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