Abstract:
:Vitiligo vulgaris is an autoimmune pigmentary disorder with no universally efficacious therapeutic options. Separate applications of calcipotriene ointment 0.005% and topical corticosteroid ointments have been successful in the repigmentation of vitiligo. We sought to examine the efficacy of a combination calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment in the repigmentation of vitiligo. An institutional review board-approved retrospective chart review was conducted in 13 pediatric and adult patients with vitiligo treated with calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment once daily for at least 2 months. Two of 3 children had 76% to 100% repigmentation of facial vitiligo with once-daily usage after 2 months. Of the 10 adults (aged 28-55 years), 1 had 100% facial repigmentation in 3 months, 1 had 76% to 99% facial repigmentation in 5 to 9 months, and 2 had 26% to 50% repigmentation in 3 months. Twelve patients developed some facial repigmentation. No patients experienced atrophy, telangiectases, or lesion enlargement during treatment. Combination calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment shows promise as a once-daily vitiligo therapy. Adult and pediatric facial vitiligo patients may see repigmentation as early as 2 months after initiation of therapy. Children may experience a better response, but larger studies are needed.
journal_name
Cutisjournal_title
Cutisauthors
Newman MD,Silverberg NBsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
256-9issue
5eissn
0011-4162issn
2326-6929journal_volume
88pub_type
杂志文章相关文献
CUTIS文献大全abstract::Early detection of skin cancer is essential to reducing morbidity and mortality from both melanoma and nonmelanoma skin cancers. Total-body skin examinations (TBSEs) may improve early detection of malignant melanomas (MMs) but are controversial due to the poor quality of data available to establish a mortality benefit...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
abstract::Nineteen patients with severe or recalcitrant rosacea were treated twice daily with 0.75 percent metronidazole topical gel in an open label study. Sixteen of the patients (84 percent) showed 50 percent or greater reduction in inflammatory lesions, while fifteen (79 percent) demonstrated a reduction in erythema severit...
journal_title:Cutis
pub_type: 临床试验,杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Onchocerciasis, or river blindness, is a parasitic infection caused by the filarial nematode, Onchocerca volvulus. It infects 18 million people worldwide, but is rarely seen in the United States. It is one of the leading causes of blindness in the developing world. Although onchocerciasis is also known as river blindn...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::A case of the recently described vascular tumor, the arteriovenous hemangioma, is presented herein. Clinical and histologic differentiation from other benign, acquired vascular lesions is stressed. ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::Ultraviolet exposure is an important risk factor for basal cell carcinoma. Since eyewear may have a photoprotective effect, this study evaluated the use of prescription eyeglasses and sunglasses in patients with periorbital basal cell carcinoma compared with other facial sites. There was no difference in prescription ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Soft tissue calcification has been reported following the intramuscular injection of calcium salts and the intravenous administration of calcium gluconate. The present case report describes a neonate in whom calcification of the superficial scalp veins developed following administration of calcium chloride and sodium ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::Lymphedema tarda is a rare form of primary lymphedema. Its cause is unknown; an autoimmune destruction of lymphatic channels can be hypothesized. A case of lymphedema tarda in which direct immunofluorescent studies of involved tissue showed no immune deposits is presented. The differential diagnosis of this condition ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract::When performing a total body skin examination, we discovered a melanoma in situ when a patient took off her wristwatch. This case illustrates the importance of removing jewelry when performing a complete skin examination. Furthermore, the location of this lesion highlights the association between malignant melanoma an...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::A single case of trichorhinophalangeal syndrome, type I, is reported. The patient manifested the complete triad of the syndrome: thin, sparse, slow-growing scalp hairs; a pear-shaped nose; and cone-shaped epiphysis in some interphalangeal articulations of both hands. In addition, tooth decay, pectus carinatum, lumbar ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Porokeratosis is a rare keratinization disorder of the skin characterized by annular plaques with an atrophic center surrounded by a raised keratotic wall that spreads centrifugally. We report a case of porokeratosis of Mibelli with mutilation. A 30-year-old woman presented with atrophic plaques on the index fingers o...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::Many disorders produce anhidrosis, including abnormalities of the central or peripheral nervous system. Tumors, infarcts, injuries, or hemorrhages of the brain can be the cause. We describe two patients with anhidrosis due to neurologic causes. One patient had an acquired complete left unilateral anhidrosis without an...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::A 21-year-old man presented with hypertrophic nail dystrophy and subungual debris of all 20 nails, hyperkeratotic plaques on the heels of both feet, and oral leukokeratosis. He had an extensive family history of similar clinical findings. The patient's clinical presentation and history were consistent with pachyonychi...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract::Lobomycosis is a deep fungal disease of the skin without involvement of internal organs or mucous membranes. The disease is characterized by skin nodules and plaques resembling keloid involving the earlobes, distal parts of the upper and lower extremities, and buttocks. In severe cases, large skin areas can be covered...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract::We report a case of fixed drug eruption secondary to sulindac (Clinoril). Owing to the drug's current popularity we believe that physicians should be made aware of this phenomenon. We present a patient who had the unusual feature of hypopigmentation associated with healing of his lesion. A brief review of clinical fea...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract::A 44-year-old man presented with an eruption of pruritic erythematous plaques on his lower extremities of 6 months' duration that were unresponsive to antifungal cream or topical corticosteroid. His medical history was notable for chronic inflammatory demyelinating polyneuropathy (CIDP), which was diagnosed 1 year pri...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract::Inquiries regarding tick exposure can be important in dermatologic diagnosis and treatment since ticks can be vectors of a diversity of infectious diseases. The classic teaching is that ticks are best removed with nail polish, solvents, petrolatum, mineral oil, or a hot match. However, a recent evaluation of tick remo...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::An allergic reaction provoked by reexposure to an allergen or antigen is known as a type I or immediate hypersensitivity reaction. Latex allergy is a common cause of type I hypersensitivity reactions. Allergic responses to latex in psoriasis patients receiving frequent injections with biologic agents are not commonly ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2018-08-01 00:00:00
abstract::Four subjects were exposed to dorsal spines of the Automeris io caterpillar. The experimental presented herein indicates that there is a substantial variability in response between human subjects. The urticarial reaction produced can be categorized broadly as contact urticarda and most probably is nonimmunologic, depe...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::A small proportion of patients with alpha1-antitrypsin (alpha1AT) deficiency experience recurrent ulcerating panniculitis. Studies suggest that alpha1AT-deficiency panniculitis reflects an uncontrolled inflammatory process because of the serum's incapacity to neutralize proteolytic enzymes released by leukocytes in th...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::Rosacea is a chronic inflammatory disease that predominantly affects facial skin in light-skinned individuals and can be divided into 4 subtypes. Patients can display signs of more than 1 subtype. Diffuse facial erythema is a common finding in rosacea patients and can lead to persistent erythema. Although there is no ...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2014-07-01 00:00:00
abstract::Twenty consecutive patients with acute cellulitis were studied by retrospective chart review. Patients with suffusion and edema, with or without vesicles, were included. Patients with breaks in the skin, with focal suppurations or with concurrent antimicrobial therapy were excluded. In nineteen of the twenty patients,...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::An outbreak of KS has been observed in young homosexual men. These patients are different from those with classical KS for the following reasons: 1. geographic distribution (clustering in New York and California); 2. age (younger, mean--39 years); 3. higher incidence; 4. sexual preference (homosexual); 5. distribution...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Angioedema is a variant of urticaria that causes deep dermal and subcutaneous swelling. It frequently is a unilateral reaction and usually lasts for several hours but may persist for several days. We report 2 cases of angioedema that involved the right upper and lower eyelids and was associated with congestion of the ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::We report the case of a 64-year-old man with androgenetic alopecia who was started on methotrexate therapy for treatment of psoriasis after traditional modalities failed. Following treatment with methotrexate, he noted hair regrowth on the scalp. We propose that methotrexate may inhibit gonadal steroidogenesis, theref...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::Molluscum contagiosum is an infection caused by a poxvirus that gives rise to small, benign, white, pink, or flesh-colored, umbilicated, raised papules or nodules located in the epidermal layer of the skin. The disease can be transmitted by direct bodily contact including sexual activity, fomites, or self-inoculation....
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract::A case of gold salt-induced oral lichen planus is reported. The oral lesions were successfully managed with a topical corticosteroid rinse. Gold salts, oral symptoms, and the use of the systemic inducing agent/immunosuppressant in combination with a topical corticosteroid are reviewed. ...
journal_title:Cutis
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Choriocarcinoma, a malignancy of trophoblastic cells, is characterized by the secretion of human chorionic gonadotropin (hCG). Choriocarcinoma primarily arises from the fetal (placental) trophoblasts in the setting of a molar pregnancy. Nongestational choriocarcinoma from the ovary or testis is much rarer. Testicular ...
journal_title:Cutis
pub_type: 杂志文章,评审
doi:
更新日期:2001-02-01 00:00:00
abstract::Despite the many beneficial effects of dermatologic applications, most of the current treatments for acne cause local irritation. The objective of this study was to compare the ability of the epidermis to tolerate adapalene 0.1% cream and gel and tazarotene cream in concentrations of 0.05% and 0.1%. A total of 30 subj...
journal_title:Cutis
pub_type: 临床试验,杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::The effect of zinc pyrithione 1 percent, incorporated in a shampoo, has been tested in an open trial of twenty patients with tinea versicolor. The period of treatment was two weeks, and eighteen patients returned for follow-up visits two weeks after the last day of treatment. All of these patients were cured of tinea ...
journal_title:Cutis
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Patients with rosacea form a unique subset of the sensitive skin population because of the barrier defects inherent in this condition and the increased propensity for burning/stinging from topical products. This propensity for burning/ stinging when medications, skin care products, or cosmetics are applied to the faci...
journal_title:Cutis
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-10-01 00:00:00