Abstract:
CONTEXT:Recent randomized controlled trials have shown a significant decrease in unsatisfactory rates for liquid-based cytology (LBC) compared with conventional Papanicolaou test (CP). The underlying causes and relevance of unsatisfactory results for LBC and CP have never been compared within the setting of a randomized controlled trial. OBJECTIVE:To examine differences in causes and relevance of unsatisfactory and satisfactory but limited by (SBLB) results for LBC and CP. DESIGN:Data from the Netherlands ThinPrep Versus Conventional Cytology (NETHCON) trial were used, involving 89 784 women. Causes and relevance of unsatisfactory and SBLB results were analyzed. RESULTS:The primary cause for unsatisfactory results for CP and LBC was scant cellularity. Other causes for unsatisfactory CPs were virtually eliminated with LBC. The same was true for SBLB subcategories, with the exception of SBLB absence of transformation zone component and SBLB scant cellularity. The SBLB absence of transformation zone component showed a statistically significant 22% and SBLB scant cellularity a 12% nonsignificant increase with LBC. The detection rates of abnormalities found during 18 months of follow-up of unsatisfactory test results did not differ significantly between the 2 study arms, nor did they differ from the initial test positivity rates from the NETHCON trial. CONCLUSIONS:Liquid-based cytology shows an almost complete elimination of most causes for unsatisfactory CP, with scant cellularity remaining as the sole cause for unsatisfactory LBC. On the other hand, with LBC a significant increase of smears without a transformation zone component was noted. Women with an unsatisfactory test result are not at increased risk for cervical abnormalities either with LBC or with CP. TRIAL REGISTRATION:Nederlands Trial Register, NTR1032, www.trialregister.nl .
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Siebers AG,Klinkhamer PJ,Vedder JE,Arbyn M,Bulten Jdoi
10.5858/arpa.2011-0113-OAsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
76-83issue
1eissn
0003-9985issn
1543-2165journal_volume
136pub_type
杂志文章abstract::Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or "phen-fen") was recently marketed in the United States. We describe a case of a 39-year-old woman with rapidly ...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/0003-9985(1999)123<0539:CVLAAI>2.0.CO;2
更新日期:1999-06-01 00:00:00
abstract:CONTEXT:Since 1988, the College of American Pathologists has been offering materials for calibration verification coupled with the surveys for linearity, called the linearity (LN) surveys. OBJECTIVE:To determine whether successful completion of the College of American Pathologists LN surveys provides a benefit in term...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165(2004)128<544:CVPRTP>2.0.CO;2
更新日期:2004-05-01 00:00:00
abstract::Findings of a histochemical and ultrastructural study of the mucogenic cells of congenital adenomatoid malformation of lung indicate that these cells share features with goblet cells of bronchial or intestinal origin and do not indicate a similarity to normal gastric epithelium or glands, as has been previously sugges...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Myocyte injury in acute cardiac transplant rejection was studied ultrastructurally in 45 patients. Mild myocyte injury consisted of increased glycogen granules and mitochondria, and condensation and streaming of myofilaments. More severe cell injury was characterized by clumping of Z-band material at the periphery of ...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:CONTEXT:Turnaround time (TAT) for large or complex surgical pathology specimens is an indicator of efficiency in anatomic pathology and may affect coordination of patient care. OBJECTIVE:To establish benchmarks for TAT and to identify practice characteristics that may influence TAT. DESIGN:Participants in a 2012 Q-Pr...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.5858/arpa.2013-0671-CP
更新日期:2015-02-01 00:00:00
abstract::A 42-year-old man with acquired immunodeficiency syndrome developed a mass of the right parotid gland and multiple hepatic masses. Hematoxylin-eosin-stained sections of the parotid lesion showed a diffuse infiltrate of large mononuclear cells with vesicular nuclei and prominent nucleoli, consistent with a non-Hodgkin ...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/0003-9985(2002)126<0738:NKLTCL>2.0.CO;2
更新日期:2002-06-01 00:00:00
abstract:CONTEXT:Recent changes in pathology residency education have included a decrease in the program length (from 5 years to 4 years for combined anatomic and clinical pathology training) and a national mandate for programs to assess 6 general competencies of trainees. These have undoubtedly led to changes in program curric...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165-133.9.1431
更新日期:2009-09-01 00:00:00
abstract::Idiopathic nephrotic syndrome occurred in a patient with sarcoidosis. Typical features of focal segmental glomerulosclerosis were present on kidney biopsy. A unique finding was the occurrence of IgA in blood vessels of the skin and lymph node. Whereas the sarcoid hilar adenopathy responded to steroid therapy, the neph...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:CONTEXT:Accurate specimen identification is critical for quality patient care. Improperly identified specimens can result in delayed diagnosis, additional laboratory testing, treatment of the wrong patient for the wrong disease, and severe transfusion reactions. Specimen identification errors have been reported to occu...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,多中心研究
doi:10.1043/1543-2165(2008)132[1617:SLEAQA]2.0.CO;2
更新日期:2008-10-01 00:00:00
abstract::Embolic cerebellar tissue was observed microscopically in the pulmonary and coronary arteries of a full-term male infant who died 1 hour after forceps delivery. Although embolization of brain tissue has been well documented after severe head trauma in adults and children, to our knowledge only 17 cases associated with...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-01 00:00:00
abstract::Microcystic transitional cell carcinoma is a rare variant of urothelial carcinoma; to date, it has been described only in the urinary bladder. We report 2 cases of microcystic transitional cell carcinoma arising in the renal pelvis. The first case occurred in a 73-year-old man with a history of superficially invasive ...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/0003-9985(2002)126<0859:MTCC>2.0.CO;2
更新日期:2002-07-01 00:00:00
abstract::We present the case of a 30-year-old woman who suddenly developed intense occipital headaches. Computed tomography and magnetic resonance imaging demonstrated a cyst located ventrally to the brain stem at the pontomedullary junction. The lesion was resected. Histologically, it was lined by a pseudostratified, ciliated...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract::Striated muscle cells coexisting with neuroglial tissue were found in the leptomeninges of a 3-day-old neonate. An immunohistochemical study demonstrated the presence of myoglobin in the striated muscle cells, glial fibrillary acidic protein, and S-100 protein in the heterotopic glia, S-100 protein in the Schwann cell...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract:CONTEXT.—:The College of American Pathologists guidelines recommend testing additional tumor foci in multifocal invasive breast carcinomas for the biomarkers estrogen receptor (ER), progesterone receptor, and HER2 only if the carcinomas show different morphologies or grades. OBJECTIVE.—:To assess clinical significance...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.5858/arpa.2017-0494-OA
更新日期:2019-02-01 00:00:00
abstract::We report a primary intraocular T-cell-rich large B-cell lymphoma in a 57-year-old woman who underwent 3 diagnostic vitrectomies for a presumed diagnosis of panuveitis. She developed no light perception in the left eye and underwent enucleation. Histopathologic and immunohistochemical studies on the enucleated globe d...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165(2005)129[1050:PITLBL]2.0.CO;2
更新日期:2005-08-01 00:00:00
abstract::Metastatic Crohn disease is a rare cutaneous disorder characterized by noncaseating, granulomatous skin lesions present at sites anatomically separate from the gastrointestinal tract. It is the least common dermatologic manifestation of Crohn disease, and the differential diagnosis includes numerous similarly appearin...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.5858/arpa.2010-0666-RS
更新日期:2012-03-01 00:00:00
abstract::Discrepancies between the hematocrit values measured by automated methods and those measured by centrifugation have discouraged the use of the centrifuged microhematocrit to calibrate automated hematology analyzers. The discrepancy appears to be due to changes in the internal viscosity of red blood cells and can be el...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract::Histopathology is based on the interpretation of features of the microscopic image. In recent years, there has evolved interest in assessing quantifiable data from these images, with the intent of providing more precise diagnostic and prognostic information. Proliferation characteristics of tumors are among the most i...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract::Benign heterotopic epithelial inclusions in axillary lymph nodes are an extremely rare condition that must be differentiated from metastatic carcinoma. We describe 2 histologically different examples of benign epithelial inclusions in nonsentinel axillary lymph nodes, each with an unusual clinical presentation. ...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/0003-9985(2003)127
更新日期:2003-01-01 00:00:00
abstract::Assays for Chlamydia trachomatis antigen are being increasingly used in lieu of traditional cell culture methods for detection of the organism in patient specimens. While results from these assays are available considerably earlier than are those from culture, the assays have been less sensitive and specific than cult...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1989-05-01 00:00:00
abstract::Although it has long been recognized that hyperbilirubinemia is enhanced in patients with impaired renal function, a clear correlation between the levels of bilirubin and creatinine in serum has never been established. We have studied this relationship in 13 bone marrow transplant recipients who had episodes of combin...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::We describe the pathomorphologic features of 29 autopsy cases of thorium dioxide-related angiosarcoma (AGS) of the liver. The average (+/- SD) latent period after thorium dioxide injection was 36.2 +/- 5.2 years. Macroscopically, thorium dioxide-related AGS was divided into four types as follows: diffuse micronodular,...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:CONTEXT:The differential diagnoses of prostatic carcinoma and bladder epithelial neoplasms include several histologic mimics that should be known to avoid misdiagnosis. OBJECTIVE:To discuss pseudoneoplastic lesions of the prostate and bladder that could potentially be confused with prostatic carcinoma and bladder epit...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/1543-2165-134.3.427
更新日期:2010-03-01 00:00:00
abstract::The blood supply to the upper ventricular septum in the region of the conduction system is more abundant than the literature suggests. I found a significant arterial contribution to the upper ventricular septum from the proximal segment of the right coronary artery (RCA), or one of its early branches, in 77% of 65 hea...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:To summarize current knowledge and recent progress pertaining to platelet concentrate preparations, modifications, and future prospects for platelet substitutes. METHODS:Current publications identified through a search of an electronic literature database were evaluated and reviewed. Relevant data were abstr...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/0003-9985(1999)123<0889:P>2.0.CO;2
更新日期:1999-10-01 00:00:00
abstract::We report the case of a patient treated with a combination of fludarabine and cyclophosphamide after suffering from B-cell chronic lymphocytic leukemia for 10 years. Three months after treatment, the patient presented with an unusual association, not previously reported in the literature: Richter syndrome (monotypic E...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165(2006)130[1227:CEVLBL]2.0.CO;2
更新日期:2006-08-01 00:00:00
abstract:CONTEXT:In the normal course of activity, pathologists create and archive immense data sets of scientifically valuable information. Researchers need pathology-based data sets, annotated with clinical information and linked to archived tissues, to discover and validate new diagnostic tests and therapies. Pathology recor...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:10.1043/1543-2165(2003)127<680:CMDS>2.0.CO;2
更新日期:2003-06-01 00:00:00
abstract::A survey of manpower supply and need in academic pathology departments was conducted by the Joint Task Force on Pathology Manpower of the College of American Pathologists, the American Society of Clinical Pathologists, and the Association of Pathology Chairmen by means of questionnaires distributed to chairmen and fac...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::The monoclonal antibody HMB-45 is a highly specific and sensitive marker of malignant melanoma. Rarely, however, aberrant reactivity to nonmelanocytic tumors has been observed. We report an immunoblastic lymphoma of B-cell phenotype that reacted with HMB-45 in a 70-year-old white woman. To our knowledge, this is the f...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVES:To review the state of the art relating to elevated hemostatic factor levels as a potential risk factor for thrombosis, as reflected by the medical literature and the consensus opinion of recognized experts in the field, and to make recommendations for the use of specific measurements of hemostatic factor le...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:10.1043/0003-9985(2002)126<1405:EHFLAP>2.0.CO;2
更新日期:2002-11-01 00:00:00