Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial.

Abstract:

:In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).

journal_name

Sex Transm Dis

authors

Baeten JM,Reid SE,Delany-Moretlwe S,Hughes JP,Wang RS,Wilcox E,Limbada M,Akpomiemie G,Corey L,Wald A,Celum C

doi

10.1097/OLQ.0b013e31823b50c6

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

21-4

issue

1

eissn

0148-5717

issn

1537-4521

pii

00007435-201201000-00005

journal_volume

39

pub_type

杂志文章,随机对照试验
  • Sexually transmitted disease syndromes in rural South Africa. Results from health facility surveillance.

    abstract:BACKGROUND AND OBJECTIVE:Surveillance for sexually transmitted diseases (STD) is important for priority setting, service development, and evaluating interventions. GOAL:To conduct health facility-based surveillance for STDs to inform design of a control program and to provide baseline measures for evaluation of interv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199801000-00005

    authors: Wilkinson D,Connolly AM,Harrison A,Lurie M,Karim SS

    更新日期:1998-01-01 00:00:00

  • Conceptualizing Geosexual Archetypes: Mapping the Sexual Travels and Egocentric Sexual Networks of Gay and Bisexual Men in Toronto, Canada.

    abstract:BACKGROUND:There are complex, synergistic, and persistent sexually transmitted infection (STI) epidemics affecting gay, bisexual and other men who have sex with men (gbMSM) in every major urban centre across North America. We explored the spatial architecture of egocentric sexual networks for gbMSM in Toronto, Canada. ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000752

    authors: Gesink D,Wang S,Guimond T,Kimura L,Connell J,Salway T,Gilbert M,Mishra S,Tan D,Burchell AN,Brennan DJ,Logie CH,Grace D

    更新日期:2018-06-01 00:00:00

  • Persistent nongonococcal urethritis associated with a minocycline-resistant strain of Ureaplasma urealyticum: a case report.

    abstract::Culture of urethral specimens from a 21-year-old man with nongonococcal urethritis yielded both Chlamydia trachomatis and a minocycline-resistant strain of Ureaplasma urealyticum. In such situations, the causal agent of the urethritis is frequently considered to be C. trachomatis. However, the etiology of this case wa...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:

    authors: Magalhães M

    更新日期:1983-07-01 00:00:00

  • Acyclovir ointment does not affect the dark-field examination in primary syphilis.

    abstract::In the cases of two patients and in a rabbit with experimental syphilis, treatment of primary syphilis lesions with 5% acyclovir ointment did not affect detection of Treponema pallidum by dark-field microscopy. These results indicate that the dark-field examination need not be delayed in patients whose genital ulcers ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198311000-00008

    authors: Roddy R,Lukehart SA,Handsfield HH

    更新日期:1983-10-01 00:00:00

  • Observed Treatment Responses to Short-Course Doxycycline Therapy for Rectal Lymphogranuloma Venereum in Men Who Have Sex With Men.

    abstract:BACKGROUND:Lymphogranuloma venereum (LGV) has reestablished itself as an endemic sexually transmitted infection in the United Kingdom and elsewhere in Europe and North America over the last decade. Current guidelines suggest treatment with 21 days of doxycycline; however, the evidence base for LGV treatment including i...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000772

    authors: Simons R,Candfield S,French P,White JA

    更新日期:2018-06-01 00:00:00

  • Diagnostic considerations in intra-amniotic syphilis.

    abstract::Amniotic fluid is rarely used in the evaluation of syphilis during pregnancy but was available from a woman with positive serologic tests in the 30th week of gestation. Nonmotile intra-amniotic spirochetes were seen by dark-field microscopy 20 hr after treatment with benzathine penicillin G. The identity of the organi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198507000-00010

    authors: Glover DD,Winter CA,Charles D,Larsen B

    更新日期:1985-07-01 00:00:00

  • Factors associated with condom use problems during vaginal sex with main and non-main partners.

    abstract:BACKGROUND:Incorrect condom use is a common problem that can undermine their prevention impact. We assessed the prevalence of 2 condom use problems, breakage/slippage and partial use, compared problems by partnership type, and examined associations with respondent, partner, and partnership characteristics. METHODS:Dat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/OLQ.0b013e31825ef325

    authors: DʼAnna LH,Korosteleva O,Warner L,Douglas J,Paul S,Metcalf C,McIlvaine E,Malotte CK,RESPECT-2 Study Group.

    更新日期:2012-09-01 00:00:00

  • Developing a predictive model to prioritize human immunodeficiency virus partner notification in North Carolina.

    abstract:BACKGROUND:Disease intervention specialists (DIS) in North Carolina have less time to conduct partner notification because of competing responsibilities while simultaneously facing increased case loads because of increased human immunodeficiency virus (HIV) testing. We developed a model to predict undiagnosed HIV infec...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318239da4e

    authors: Hoots BE,MacDonald PD,Hightow-Weidman LB,Leone PA,Miller WC

    更新日期:2012-01-01 00:00:00

  • Seroprevalence of human immunodeficiency virus type I (HIV-1) antibodies in a family-planning population.

    abstract::Blind testing of 743 women who attended an inner-city hospital family-planning clinic showed 8 (1.1%) patients to have serum antibodies to human immunodeficiency virus type I (HIV-1). A retrospective chart survey did not show an association between HIV-1 antibody seropositivity and ethnicity, marital status, education...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199107000-00003

    authors: Spence MR,Robbins SM,Polansky M,Schable CA

    更新日期:1991-07-01 00:00:00

  • Sexual bridging socially and over time: a simulation model exploring the relative effects of mixing and concurrency on viral sexually transmitted infection transmission.

    abstract:BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic mo...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000194586.66409.7a

    authors: Doherty IA,Shiboski S,Ellen JM,Adimora AA,Padian NS

    更新日期:2006-06-01 00:00:00

  • A solid-phase enzyme immunoassay (Gonozyme) test for direct detection of Neisseria gonorrhoeae antigen in urogenital specimens from patients at a sexually transmitted disease clinic.

    abstract::The Gonozyme test (Abbott Laboratories; North Chicago, IL), a solid-phase enzyme immunoassay (EIA), was evaluated for direct detection of antigens from Neisseria gonorrhoeae in clinical specimens. Results of the EIA were compared with those of culture and gram stain. Separate swab specimens for each procedure were col...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198510000-00006

    authors: Nasello MA,Callihan DR,Menegus MA,Steigbigel RT

    更新日期:1985-10-01 00:00:00

  • Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity.

    abstract:BACKGROUND:Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity. GOALS:The objective of this analysis was to examine the association of sexual behavior, cervical HPV 16 DNA positivity at enrollment (past) and at diagnosis (current), and oth...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200203000-00009

    authors: Castle PE,Shields T,Kirnbauer R,Manos MM,Burk RD,Glass AG,Scott DR,Sherman ME,Schiffman M

    更新日期:2002-03-01 00:00:00

  • Evaluation of self-collected versus clinician-collected swabs for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae pharyngeal infection among men who have sex with men.

    abstract::We evaluated self-sampling to detect pharyngeal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection among men who have sex with men attending a San Francisco STD clinic. The prevalence of pharyngeal NG and CT infection was 6.7% (32/480) and 1.3% (6/480), respectively. The percent agreement between self...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318227713e

    authors: Freeman AH,Bernstein KT,Kohn RP,Philip S,Rauch LM,Klausner JD

    更新日期:2011-11-01 00:00:00

  • The costs of treating curable sexually transmitted infections in low- and middle-income countries: a systematic review.

    abstract:BACKGROUND:Calls for increased investment in sexually transmitted infection (STI) treatment across the developing world have been made to address the high disease burden and the association with HIV transmission. GOALS:The goals of this study were to systematically review evidence on the cost of treating curable STIs ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.olq.0000235177.30718.84

    authors: Terris-Prestholt F,Vyas S,Kumaranayake L,Mayaud P,Watts C

    更新日期:2006-10-01 00:00:00

  • Estimating the Total Annual Direct Cost of Providing Sexually Transmitted Infection and HIV Testing and Counseling for Men Who Have Sex With Men in the United States.

    abstract:BACKGROUND:The Centers for Disease Control and Prevention recommends annual sexually transmitted infection (STI) and HIV testing and counseling for men who have sex with men (MSM) in the United States. We estimated the annual total direct medical cost of providing recommended STI and HIV testing and counseling services...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000341

    authors: Owusu-Edusei K Jr,Gift TL,Patton ME,Johnson DB,Valentine JA

    更新日期:2015-10-01 00:00:00

  • Centers for Disease Control and Prevention Syphilis Summit: Difficult Clinical and Patient Management Issues.

    abstract::Despite over a century of clinical experience in diagnosing and managing patients with syphilis, many thorny clinical questions remain unanswered. We focus on several areas of uncertainty for the clinician: the role of serologic tests in diagnosing syphilis and assessing syphilis treatment responses, and the risk of n...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/OLQ.0000000000000851

    authors: Marra CM,Ghanem KG

    更新日期:2018-09-01 00:00:00

  • Predictors of condom use among patients with sexually transmitted diseases in Uganda.

    abstract:BACKGROUND AND OBJECTIVE:Patients with sexually transmitted diseases (STDs) are at an increased risk of HIV infection and they must be targeted for increased condom use. GOAL:To identify predictors of condom use among patients with STDs. STUDY DESIGN:In a cross-sectional survey, an interview-administered questionnair...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199910000-00001

    authors: Nuwaha F,Faxelid E,Höjer B

    更新日期:1999-10-01 00:00:00

  • Zenilman's anomaly reconsidered: fallible reports, ceteris paribus, and other hypotheses.

    abstract:BACKGROUND AND OBJECTIVES:In the January-February, 1995 issue of Sexually Transmitted Diseases, Zenilman and colleagues reported a null association between incident sexually transmitted diseases (STDs) and self-reported condom use. That anomalous finding generated a flurry of letters to the editor, some of which were q...

    journal_title:Sexually transmitted diseases

    pub_type: 评论,杂志文章

    doi:10.1097/00007435-199710000-00005

    authors: Turner CF,Miller HG

    更新日期:1997-10-01 00:00:00

  • Measuring the in vitro susceptibility of Trichomonas vaginalis to metronidazole: a disk broth method.

    abstract::Strains of Trichomonas vaginalis were evaluated for their in vitro responses to metronidazole. A serial twofold dilution method that measured minimal inhibitory concentrations (MICs) by cessation of trophozoite motility was compared with the disk broth method, in which both cessation of motility and inhibition of trop...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198007000-00005

    authors: Smith RF,Di Domenico A

    更新日期:1980-07-01 00:00:00

  • HIV Testing, HIV Positivity, and Linkage and Referral Services in Correctional Facilities in the United States, 2009-2013.

    abstract:BACKGROUND:Because of health disparities, incarcerated persons are at higher risk for multiple health issues, including HIV. Correctional facilities have an opportunity to provide HIV services to an underserved population. This article describes Centers for Disease Control and Prevention (CDC)-funded HIV testing and se...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000353

    authors: Seth P,Figueroa A,Wang G,Reid L,Belcher L

    更新日期:2015-11-01 00:00:00

  • Use of a Novel Couples' Verification Tool in a Male Partner Treatment Study of Women With Recurrent Bacterial Vaginosis.

    abstract::Verification of relationship status beyond self-report is an important aspect in sexually transmitted infection research, including partner treatment studies where primary sexual partners are targeted for enrollment. This exploratory study describes the use of a novel couples' verification tool in a male partner treat...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001225

    authors: Muzny CA,Pontius A,Woznicki N,Hudak KE,Lensing SY,Sobel JD,Schwebke JR

    更新日期:2020-12-01 00:00:00

  • The cost effectiveness of gonorrhea screening in urban emergency departments.

    abstract:BACKGROUND:The prevalence of gonorrhea (GC) among adolescent and young women attending some urban emergency departments (EDs) ranges from 1% to 7%, but historically screening has not been logistically practical. GOAL:The primary goal of the study was to assess the cost effectiveness of GC screening in women ages 15 to...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000154501.22566.fa

    authors: Aledort JE,Hook EW 3rd,Weinstein MC,Goldie SJ

    更新日期:2005-07-01 00:00:00

  • Reliable identification of herpes simplex viruses by DNA restriction endonuclease analysis with EcoRI.

    abstract::A simple procedure that permits the rapid identification of clinical isolates of herpes simplex virus (HSV, type 1 or type 2) on the basis of stable and type-specific differences in the EcoRI restriction endonuclease patterns of the HSV-1 and HSV-2 genomes was tested for reliability. Complete concordance was first obt...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198404000-00007

    authors: Gerson M,Portnoy J,Hamelin C

    更新日期:1984-04-01 00:00:00

  • Susceptibility of Chlamydia trachomatis to antibiotics in vitro and in vivo.

    abstract::The susceptibility of Chlamydia trachomatis to antibiotics was studied in vitro and in patients with nongonococcal urethritis. The minimal inhibitory concentrations of cloxacillin, erythromycin, pivampicillin, oxytetracycline, and doxycycline, which were the most effective drugs, were 10, 0.5, 0.25, 0.1, and 0.5 micro...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-197904000-00002

    authors: Johannisson G,Sernryd A,Lycke E

    更新日期:1979-04-01 00:00:00

  • HIV Screening Among Gonorrhea-Diagnosed Individuals; Baltimore, Maryland; April 2015 to April 2019.

    abstract:BACKGROUND:Individuals diagnosed with gonorrhea are at elevated risk for HIV. Per US Centers for Disease Control and Prevention guideline, individuals being evaluated for gonorrhea should be screened for HIV concurrently. There is limited information on HIV screening among gonorrhea-diagnosed individuals across differe...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001252

    authors: Williford SL,Humes E,Greenbaum A,Schumacher CM

    更新日期:2021-01-01 00:00:00

  • A randomized controlled trial of partner notification methods for prevention of trichomoniasis in women.

    abstract:BACKGROUND:Trichomoniasis is associated with adverse pregnancy outcomes and increased risk for human immunodeficiency virus. Males are usually asymptomatic, and thus there is heavy reliance on partner notification for identifying infected male partners. The usual approach is partner referral but it is estimated that on...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/OLQ.0b013e3181dd1691

    authors: Schwebke JR,Desmond RA

    更新日期:2010-06-01 00:00:00

  • Colonization of the pharynx with Neisseria gonorrhoeae: experience in a clinic for sexually transmitted diseases.

    abstract::At a clinic for treatment of sexually transmitted diseases, 1,453 patients were examined for pharyngeal colonization with Neisseria gonorrhoeae. A history of oral sex was reported by 895 (61.2%) of the patients. N. gonorrhoeae was isolated from the pharynges of 42 (2.9%) of the 1,453 patients. Twenty-seven of the 42 p...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-197910000-00006

    authors: Osborne NG,Grubin L

    更新日期:1979-10-01 00:00:00

  • Suppressive valacyclovir therapy: impact on the population spread of HSV-2 infection.

    abstract:OBJECTIVES:Recent trial results demonstrate that the transmission probability of HSV-2 in monogamous couples is nearly halved by the use of valacyclovir as suppressive therapy. GOAL:The goal of this study is to understand the potential impact of suppressive valacyclovir therapy on the transmission of HSV-2 within a po...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000258486.81492.a2

    authors: Williams JR,Jordan JC,Davis EA,Garnett GP

    更新日期:2007-03-01 00:00:00

  • Just text me! Texting sexually transmitted disease clients their test results in Florida, February 2012-January 2013.

    abstract:BACKGROUND:In response to increasing sexually transmitted diseases (STDs), diminishing resources, and delays in prompt treatment, the Florida STD Program began providing test results through text message in 2011. The aims of the evaluation of the first year of the project were to assess (1) client uptake and completion...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000242

    authors: Rodriguez-Hart C,Gray I,Kampert K,White M,Wolfe C,Wilson M,Cooksey A

    更新日期:2015-03-01 00:00:00

  • Latent Profile Analysis of a Syndemic of Vulnerability Factors on Incident Sexually Transmitted Infection in a Cohort of Black Men Who Have Sex With Men Only and Black Men Who Have Sex With Men and Women in the HIV Prevention Trials Network 061 Study.

    abstract:BACKGROUND:Sexually transmitted infections (STIs) are important public health concerns among black men who have sex with men only (BMSMO), as well as those who have sex with both men and women (BMSMW). Sexually transmitted infections also increase risk of acquiring and HIV, which is also a critical concern. Compared wi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001208

    authors: Dyer TV,Turpin RE,Stall R,Khan MR,Nelson LE,Brewer R,Friedman MR,Mimiaga MJ,Cook RL,OʼCleirigh C,Mayer KH

    更新日期:2020-09-01 00:00:00