Abstract:
:Schizophrenia is one of the most debilitating of all common brain disorders, exacting a heavy toll on the afflicted and having a tremendous public health impact. Clinical outcome is more strongly predicted by cognitive deficits than psychotic symptoms, with no established treatment for these deficits. In this review, we discuss the status of treatment development for impaired cognition in schizophrenia. These treatments include a range of pharmacological targets within diverse neurotransmitter systems. New technologies, including transcranial magnetic stimulation and transcranial direct current stimulation, and psychological therapies, such as computer-based cognitive training, may also benefit cognition in schizophrenia. Each of these approaches shows promise and their integration may optimize benefits for patients in the future.
journal_name
Trends Cogn Scijournal_title
Trends in cognitive sciencesauthors
Minzenberg MJ,Carter CSdoi
10.1016/j.tics.2011.11.017subject
Has Abstractpub_date
2012-01-01 00:00:00pages
35-42issue
1eissn
1364-6613issn
1879-307Xpii
S1364-6613(11)00250-6journal_volume
16pub_type
杂志文章,评审abstract::Many everyday thoughts and actions are shaped not only by our direct relationships with others, but also by our knowledge of relations between third-parties. Lau et al. recently demonstrated how knowledge of one type of social relation - interpersonal similarity - shapes cognition and behavior, and shed light on the n...
journal_title:Trends in cognitive sciences
pub_type: 评论,杂志文章
doi:10.1016/j.tics.2020.05.002
更新日期:2020-07-01 00:00:00
abstract::How do the anatomically consistent functional selectivities of the brain emerge? A new study by Bola and colleagues reveals task selectivity in auditory rhythm-selective areas in congenitally deaf adults perceiving visual rhythm sequences. Here, we contextualize this result with accumulating evidence from animal and h...
journal_title:Trends in cognitive sciences
pub_type: 评论,杂志文章
doi:10.1016/j.tics.2017.03.007
更新日期:2017-05-01 00:00:00
abstract::Beat perception offers cognitive scientists an exciting opportunity to explore how cognition and action are intertwined in the brain even in the absence of movement. Many believe the motor system predicts the timing of beats, yet current models of beat perception do not specify how this is neurally implemented. Drawin...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2020.11.002
更新日期:2021-02-01 00:00:00
abstract::Psychiatric and neurological disorders have historically provided key insights into the structure-function relationships that subserve human social cognition and behavior, informing the concept of the 'social brain'. In this review, we take stock of the current status of this concept, retaining a focus on disorders th...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2012.09.006
更新日期:2012-11-01 00:00:00
abstract::Research indicates that developmental dyscalculia (DD; a mathematical deficiency) involves a single brain area abnormality - in the intraparietal sulcus. This is surprising because, (i) the behavioural deficits are heterogeneous, (ii) multiple problems are most common in most cases (co-morbidity) and (iii) different a...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2008.11.002
更新日期:2009-02-01 00:00:00
abstract::Arguments about the relative independence of visual modules in the primate brain are not new. Recently, though, these debates have resurfaced in the form of arguments about the extent to which visuomotor reaching and grasping systems are insensitive to visual illusions that dramatically bias visual perception. The fir...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01592-8
更新日期:2001-03-01 00:00:00
abstract::In studying categorization, cognitive science has focused primarily on cultural categorization, ignoring individual and institutional categorization. Because recent technological developments have made individual and institutional classification systems much more available and powerful, our understanding of the cognit...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2008.01.007
更新日期:2008-04-01 00:00:00
abstract::From the noisy information bombarding our senses, our brains must construct percepts that are veridical - reflecting the true state of the world - and informative - conveying what we did not already know. Influential theories suggest that both challenges are met through mechanisms that use expectations about the likel...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2019.11.003
更新日期:2020-01-01 00:00:00
abstract::The complementary learning systems framework provides a simple set of principles, derived from converging biological, psychological and computational constraints, for understanding the differential contributions of the neocortex and hippocampus to learning and memory. The central principles are that the neocortex has ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(02)02005-3
更新日期:2002-12-01 00:00:00
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journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01769-1
更新日期:2001-11-01 00:00:00
abstract::How does organized cognition arise from distributed brain activity? Recent analyses of fluid intelligence suggest a core process of cognitive focus and integration, organizing the components of a cognitive operation into the required computational structure. A cortical 'multiple-demand' (MD) system is closely linked t...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2020.06.012
更新日期:2020-10-01 00:00:00
abstract::Early in development, humans exhibit the ability to form categories and overlook differences for the sake of generality. This ability poses several important questions: How does categorization arise? What processes underlie category formation? And how are categories mentally represented? We argue that the development ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(03)00109-8
更新日期:2003-06-01 00:00:00
abstract::The domain-general learning mechanisms elicited in incidental learning situations are of potential interest in many research fields, including language acquisition, object knowledge formation and motor learning. They have been the focus of studies on implicit learning for nearly 40 years. Stemming from a different res...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2006.03.006
更新日期:2006-05-01 00:00:00
abstract::The ability to predict the likelihood of an aversive event is an important adaptive capacity. Certainty and uncertainty regarding pain cause different adaptive behavior, emotional states, attentional focus, and perceptual changes. Recent functional neuroimaging studies indicate that certain and uncertain expectation a...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(03)00061-5
更新日期:2003-05-01 00:00:00
abstract::The richness and complexity of data sets acquired from PET or fMRI studies of human cognition have not been exploited until recently by computational neural-modeling methods. In this article, two neural-modeling approaches for use with functional brain imaging data are described. One, which uses structural equation mo...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(99)01282-6
更新日期:1999-03-01 00:00:00
abstract::The inaugural Australian workshop in Artificial Life took place on the 11th of December 2001 at Adelaide University in South Australia. ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(00)01855-6
更新日期:2002-03-01 00:00:00
abstract::Two major non-invasive techniques in cognitive neuroscience, electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), have complementary advantages with regard to their spatial and temporal resolution. Recent hardware and software developments have made it feasible to acquire EEG and fMRI data si...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2006.09.010
更新日期:2006-12-01 00:00:00
abstract::Neural oscillations at different frequencies have recently been related to a wide range of basic and higher cognitive processes. One possible role of oscillatory activity is to assure the maintenance of information in working memory (WM). Here we review the possibility that rhythmic activity at theta, alpha, and gamma...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2013.10.010
更新日期:2014-01-01 00:00:00
abstract::Recent research provides new insights into amygdala contributions to positive emotion and reward. Studies of neuronal activity in the monkey amygdala and of autonomic responses mediated by the monkey amygdala show that, contrary to a widely held view, the amygdala is just as important for processing positive reward an...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2007.08.013
更新日期:2007-11-01 00:00:00
abstract::It has long been debated whether eye movements play a functional role in visual mental imagery. A recent paper by Laeng and Teodorescu presents new evidence that eye movements are stored as a spatial index that is used to arrange the component parts correctly when mental images are generated. ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(02)01931-9
更新日期:2002-07-01 00:00:00
abstract::When a brief flash appears at the same position as a moving object, the flash is perceived to lag behind. This so-called flash-lag effect tells us something about the perception of space and time: where is the moving object when the flash appears? A recent paper by Alais and Burr on auditory and crossmodal flash-lag e...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/s1364-6613(03)00133-5
更新日期:2003-07-01 00:00:00
abstract::The ease with which highly developed brains can generate representations of a virtually unlimited diversity of perceptual objects indicates that they have developed very efficient mechanisms to analyse and represent relations among incoming signals. Here, we propose that two complementary strategies are applied to cop...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/S1364-6613(97)01079-6
更新日期:1997-10-01 00:00:00
abstract::Interactions between functional areas are often considered to account for subtle aspects of cognitive functions, although direct experimental evidence is scarce. A recent study by Gross et al. relates the strength of synchrony between human parietal, frontal and occipital regions to the availability of attentional res...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2004.10.008
更新日期:2004-12-01 00:00:00
abstract::Tourette syndrome (TS) is a neurological disorder characterized by vocal and motor tics. TS is associated with impairments in behavioral inhibition, dysfunctional signaling of the inhibitory neurotransmitter GABA, and alterations in the balance of excitatory and inhibitory influences within brain networks implicated i...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2015.08.006
更新日期:2015-11-01 00:00:00
abstract::According to dual-process models, recognition memory is supported by distinct retrieval processes known as familiarity and recollection. Important evidence supporting the dual-process framework has come from studies using event-related brain potentials (ERPs). These studies have identified two topographically distinct...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2007.04.004
更新日期:2007-06-01 00:00:00
abstract::It is argued here that cognitive science currently neglects an important source of insight into the human mind: the effects created by magicians. Over the centuries, magicians have learned how to perform acts that are perceived as defying the laws of nature, and that induce a strong sense of wonder. This article argue...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2008.05.008
更新日期:2008-09-01 00:00:00
abstract::A new study shows a leftward asymmetry of the choroid plexus in two-thirds of first-trimester human fetuses. This is the earliest brain asymmetry so far identified and may be a precursor to other asymmetries, including that of the temporal planum, which is evident from the 31st week of gestation. ...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2013.09.008
更新日期:2013-11-01 00:00:00
abstract::Political disputes ruin family reunions, scuttle policy initiatives, and spur violence and even terrorism. We summarize recent research indicating that the source of political differences can be found in biologically instantiated and often subthreshold predispositions as reflected in physiological, cognitive, and neur...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2013.12.010
更新日期:2014-03-01 00:00:00
abstract::Traditionally, models of speech comprehension and production do not depend on concepts and processes from the phonological short-term memory (pSTM) literature. Likewise, in working memory research, pSTM is considered to be a language-independent system that facilitates language acquisition rather than speech processin...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章
doi:10.1016/j.tics.2006.09.002
更新日期:2006-11-01 00:00:00
abstract::The distinction between episodic and semantic memory was first proposed in 1972 by Endel Tulving and is still of central importance in cognitive neuroscience. However, data obtained over the past 30 years or so support the idea that the frontiers between perception and knowledge and between episodic and semantic memor...
journal_title:Trends in cognitive sciences
pub_type: 杂志文章,评审
doi:10.1016/j.tics.2019.09.008
更新日期:2019-12-01 00:00:00